Visualitza per autoria "Martinelli, Paola"

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  • A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer
    Kloesch, Bernhard; Ionasz, Vivien; Paliwal, Sumit; Hruschka, Natascha; Martínez de Villarreal, Jaime; Öllinger, Robert; Mueller, Sebastian; Dienes, Hans Peter; Schindl, Martin; Gruber, Elisabeth S.; Stift, Judith; Herndler-Brandstetter, Dietmar; Lomberk, Gwen A.; Seidler, Barbara; Saur, Dieter; Rad, Roland; Urrutia, Raul A.; Real, Francisco X.; Martinelli, Paola (BMJ Publishing Group, 2022)
    Objective: Molecular taxonomy of tumours is the foundation of personalised medicine and is becoming of paramount importance for therapeutic purposes. Four transcriptomics-based classification systems of pancreatic ductal ...
  • GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1
    Zhong, Yi; Wang, Zheng; Fu, Baojin; Pan, Fan; Yachida, Shinichi; Dhara, Mousumi; Albesiano, Emilia; Li, Li; Naito, Yoshiki; Vilardell, Felip; Cummings, Christopher; Martinelli, Paola; Li, Ang; Yonescu, Raluca; Ma, Qingyong; Griffin, Constance A; Real, Francisco X.; Iacobuzio Donahue, Christine A (Public Library of Science (PLoS), 2011)
    Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes in association with perturbations of developmental ...
  • GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer
    Martinelli, Paola; Carrillo, Enrique; Cox, Trevor; Sainz, Bruno Jr; Dusetti, Nelson; Greenhalf, William; Rinaldi, Lorenzo, 1986-; Costello, Eithne; Ghaneh, Paula; Malats i Riera, Núria; Büchler, Markus; Pajic, Marina; Biankin, Andrew V.; Iovanna, Juan; Neoptolemos, John; Real, Francisco X. (BMJ Publishing Group, 2017)
    BACKGROUND AND AIMS: The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is amplified in a subset of ...
  • The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver
    Hruschka, Natascha; Andreu Martínez, David; Real, Francisco X.; Martinelli, Paola (Nature Research, 2020)
    As the catalog of oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might have different functions and should not be lumped into one class. The transcription factor GATA3 is a ...

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