Browsing by Author "Martin, Laura"

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  • A protocol to quantify chromatin compaction with confocal and super-resolution microscopy in cultured cells
    Martin, Laura; Vicario, Chiara; Castells García, Àlvaro, 1991-; Lakadamyali, Melike; Neguembor, Maria Victoria; Cosma, Maria Pia (Elsevier, 2021)
    Here, we describe three complementary microscopy-based approaches to quantify morphological changes of chromatin organization in cultured adherent cells: the analysis of the coefficient of variation of DNA, the measurement ...
  • Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading
    Porter, Hayley; Li, Yang; Neguembor, Maria Victoria; Beltran, Manuel; Varsally, Wazeer; Martin, Laura; Tavares Cornejo, Manuel; Pezić, Dubravka; Bhamra, Amandeep; Surinova, Silvia; Jenner, Richard G.; Cosma, Maria Pia; Hadjur, Suzana (eLife, 2023)
    Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion ...
  • SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state
    Sebastián Pérez, Rubén; Nakagawa, Shoma; Tu, Xiaochuan; Aranda Aragón, Sergio; Pesaresi, Martina; Gómez García, Pablo; Alcoverro-Bertran, Marc; Gómez Vázquez, José Luis; Carnevali, Davide; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Martin, Laura; Nissim Rafinia, Malka; Meshorer, Eran; Neguembor, Maria Victoria; Di Croce, Luciano; Cosma, Maria Pia (eLife, 2023)
    Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C heterochromatin ...
  • The relationship between nanoscale genome organization and gene expression in mouse embryonic stem cells during pluripotency transition
    Garate,, Ximena; Gómez García, Pablo Aurelio; Fernández Merino, Manuel; Cadevall Anglès, Marta; Zhu, Chenggan; Castells García, Àlvaro, 1991-; Ed-Daoui, Ilyas; Martin, Laura; Ochiai, Hiroshi; Neguembor, Maria Victoria; Cosma, Maria Pia (Oxford University Press, 2024)
    During early development, gene expression is tightly regulated. However, how genome organization controls gene expression during the transition from naïve embryonic stem cells to epiblast stem cells is still poorly understood. ...
  • Transcription-mediated supercoiling regulates genome folding and loop formation
    Neguembor, Maria Victoria; Martin, Laura; Castells García, Àlvaro, 1991-; Gómez García, Pablo; Vicario, Chiara; Carnevali, Davide; Abed, Jumana AlHaj; Granados, Alba; Sebastián Pérez, Rubén; Sottile, Francesco, 1988-; Solon, Jérôme; Wu, Chao-Ting; Lakadamyali, Melike; Cosma, Maria Pia, 1970- (Elsevier, 2021)
    The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still poorly understood. Using super-resolution microscopy, we visualize that loops in intact nuclei are formed by a scaffold of cohesin ...
  • Women's contribution in understanding how topoisomerases, supercoiling, and transcription control genome organization
    Martin, Laura; Neguembor, Maria Victoria; Cosma, Maria Pia, 1970- (Frontiers, 2023)
    One of the biggest paradoxes in biology is that human genome is roughly 2 m long, while the nucleus containing it is almost one million times smaller. To fit into the nucleus, DNA twists, bends and folds into several ...

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