Browsing by Author "Martínez de Villarreal, Jaime"

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  • Kloesch, Bernhard; Ionasz, Vivien; Paliwal, Sumit; Hruschka, Natascha; Martínez de Villarreal, Jaime; Öllinger, Robert; Mueller, Sebastian; Dienes, Hans Peter; Schindl, Martin; Gruber, Elisabeth S.; Stift, Judith; Herndler-Brandstetter, Dietmar; Lomberk, Gwen A.; Seidler, Barbara; Saur, Dieter; Rad, Roland; Urrutia, Raul A.; Real, Francisco X.; Martinelli, Paola (BMJ Publishing Group, 2022)
    Objective: Molecular taxonomy of tumours is the foundation of personalised medicine and is becoming of paramount importance for therapeutic purposes. Four transcriptomics-based classification systems of pancreatic ductal ...
  • Chondronasiou, Dafni; Martínez de Villarreal, Jaime; Melendez, Elena; Lynch, Cian J.; Pozo, Natalia del; Kovatcheva, Marta; Aguilera, Mònica; Prats, Neus; Real, Francisco X.; Serrano, Manuel (Elsevier, 2022)
    Differentiated cells can be converted into pluripotent stem cells by expressing the transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) in a process known as reprogramming. Here, using single-cell RNA sequencing of ...
  • Melendez, Elena; Chondronasiou, Dafni; Mosteiro, Lluc; Martínez de Villarreal, Jaime; Fernández-Alfara, Marcos; Lynch, Cian J.; Grimm, Dirk; Real, Francisco X.; Alcamí, José; Climent, Núria; Pietrocola, Federico; Serrano, Manuel (Company of Biologists, 2022)
    The ectopic expression of the transcription factors OCT4, SOX2, KLF4 and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo ...
  • Cáceres, Marta; Quesada Diez, Rita; Iglesias, Mar; Real, Francisco X.; Villamonte, Maria; Martínez de Villarreal, Jaime; Pérez, Mónica; Andaluz, Anna; Moll, Xavier; Berjano, Enrique J.; Dorcaratto, Dimitri; Sánchez Velázquez, Patricia, 1985-; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Research, 2020)
    Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atrophy-inducing procedure. However, its influence has scarcely been described on premalignant lesions. This study describes ...
  • Martínez de Villarreal, Jaime; Kalisz, Mark; Piedrafita, Gabriel; Graña-Castro, Osvaldo; Chondronasiou, Dafni; Serrano, Manuel; Real, Francisco X. (Oxford University Press, 2023)
    Transposable elements (TE) have played a major role in configuring the structures of mammalian genomes through evolution. In normal conditions, the expression of these elements is repressed by different epigenetic regulation ...
  • Santos, Catarina P.; Lapi, Eleonora; Martínez de Villarreal, Jaime; Álvaro-Espinosa, Laura; Fernández-Barral, Asunción; Barbáchano, Antonio; Domínguez, Orlando; Laughney, Ashley M.; Megías, Diego; Muñoz, Alberto; Real, Francisco X. (Nature Research, 2019)
    Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly ...

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