Browsing by Author "Martínez de Villarreal, Jaime"

Sort by: Order: Results:

  • A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer
    Kloesch, Bernhard; Ionasz, Vivien; Paliwal, Sumit; Hruschka, Natascha; Martínez de Villarreal, Jaime; Öllinger, Robert; Mueller, Sebastian; Dienes, Hans Peter; Schindl, Martin; Gruber, Elisabeth S.; Stift, Judith; Herndler-Brandstetter, Dietmar; Lomberk, Gwen A.; Seidler, Barbara; Saur, Dieter; Rad, Roland; Urrutia, Raul A.; Real, Francisco X.; Martinelli, Paola (BMJ Publishing Group, 2022)
    Objective: Molecular taxonomy of tumours is the foundation of personalised medicine and is becoming of paramount importance for therapeutic purposes. Four transcriptomics-based classification systems of pancreatic ductal ...
  • Deciphering the roadmap of in vivo reprogramming toward pluripotency
    Chondronasiou, Dafni; Martínez de Villarreal, Jaime; Melendez, Elena; Lynch, Cian J.; Pozo, Natalia del; Kovatcheva, Marta; Aguilera, Mònica; Prats, Neus; Real, Francisco X.; Serrano, Manuel (Elsevier, 2022)
    Differentiated cells can be converted into pluripotent stem cells by expressing the transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) in a process known as reprogramming. Here, using single-cell RNA sequencing of ...
  • Natural killer cells act as an extrinsic barrier for in vivo reprogramming
    Melendez, Elena; Chondronasiou, Dafni; Mosteiro, Lluc; Martínez de Villarreal, Jaime; Fernández-Alfara, Marcos; Lynch, Cian J.; Grimm, Dirk; Real, Francisco X.; Alcamí, José; Climent, Núria; Pietrocola, Federico; Serrano, Manuel (Company of Biologists, 2022)
    The ectopic expression of the transcription factors OCT4, SOX2, KLF4 and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic stem cells. Methods based on partial and reversible in vivo ...
  • Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice
    Cáceres, Marta; Quesada Diez, Rita; Iglesias, Mar; Real, Francisco X.; Villamonte, Maria; Martínez de Villarreal, Jaime; Pérez, Mónica; Andaluz, Anna; Moll, Xavier; Berjano, Enrique J.; Dorcaratto, Dimitri; Sánchez Velázquez, Patricia, 1985-; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Research, 2020)
    Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atrophy-inducing procedure. However, its influence has scarcely been described on premalignant lesions. This study describes ...
  • Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data
    Martínez de Villarreal, Jaime; Kalisz, Mark; Piedrafita, Gabriel; Graña-Castro, Osvaldo; Chondronasiou, Dafni; Serrano, Manuel; Real, Francisco X. (Oxford University Press, 2023)
    Transposable elements (TE) have played a major role in configuring the structures of mammalian genomes through evolution. In normal conditions, the expression of these elements is repressed by different epigenetic regulation ...
  • Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
    Santos, Catarina P.; Lapi, Eleonora; Martínez de Villarreal, Jaime; Álvaro-Espinosa, Laura; Fernández Barral, Asunción; Barbáchano, Antonio; Domínguez, Orlando; Laughney, Ashley M.; Megías, Diego; Muñoz, Alberto; Real, Francisco X. (Nature Research, 2019)
    Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly ...
  • Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids
    Bustamante Madrid, Pilar; Barbáchano, Antonio; Albandea Rodríguez, David; Rodríguez Cobos, Javier; Rodríguez Salas, Nuria; Prieto Nieto, Isabel; Burgos García, Aurora; Martínez de Villarreal, Jaime; Real, Francisco X.; González Sancho, José Manuel; Larriba, María Jesús; Lafarga, Miguel; Muñoz, Alberto; Fernández Barral, Asunción (Nature Research, 2024)
    Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and cancer. Organoid cultures provide an unique tool to address these questions ...

Search DSpace

Browse

My Account

In collaboration with Compliant to Partaking