Welcome to the UPF Digital Repository

Browsing by Author "Martínez de Lagrán Cabredo, María"

Browsing by Author "Martínez de Lagrán Cabredo, María"

Sort by: Order: Results:

  • Down syndrome is a metabolic disease: altered insulin signaling mediates peripheral and brain dysfunctions
    Dierssen, Mara; Fructuoso, Marta; Martínez de Lagrán Cabredo, María; Perluigi, Marzia; Barone, Eugenio (Frontiers, 2020)
    Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21 (HSA21). In addition, trisomy of HSA21 ...
  • Lamivudine, a reverse transcriptase inhibitor, rescues cognitive deficits in a mouse model of down syndrome
    Martínez de Lagrán Cabredo, María; Elizalde-Torrent, Aleix; Paredes, Roger; Clotet, Bonaventura; Dierssen, Mara (Wiley, 2022)
    An elevated activity of retrotransposons is increasingly recognized to be implicated in a wide range of neurodegenerative and neurodevelopmental diseases. Down syndrome (DS) is the most common genetic disorder associated ...
  • Overexpression of Dyrk1A, a down syndrome candidate, decreases excitability and impairs gamma oscillations in the prefrontal cortex
    Ruiz Mejias, Marcel; Martínez de Lagrán Cabredo, María; Mattia, Maurizio; Castaño Prat, Patricia; Pérez Mendez, Lorena; Ciria Suarez, Laura; Gener, Thomas; Sancristóbal, Belen; García Ojalvo, Jordi; Gruart, Agnès; Delgado García, José María; Sanchez-Vives, Maria V.; Dierssen, Mara (Society for Neuroscience, 2016)
    The dual-specificity tyrosine phosphorylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentiation and synaptic plasticity and a major candidate of Down syndrome brain alterations and ...
  • Role of DYRK1A in hippocampal neuroplasticity : implications for Down syndrome
    Pons Espinal, Meritxell, 1986- (Universitat Pompeu Fabra, 2013-10-18)
    Synaptic connections in the brain respond throughout their lives to the activity of incoming neurons, adjusting their biological properties to increment activity-dependent changes. Hippocampal neuronal plasticity disruptions ...
  • The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
    Spruce, Thomas; Plass Pórtulas, Mireya, 1982-; Gohr, André; Ray, Debashish; Martínez de Lagrán Cabredo, María; Rot, Gregor; Nóvoa, Ana; Burguera, Demián; Permanyer, Jon; Miret-Cuesta, Marta; Zheng, Hong; Swanson, Maurice S.; Morris, Quaid; Mallo, Moises; Dierssen, Mara; Hughes, Timothy R.; Pernaute, Barbara; Irimia, Manuel (Public Library of Science (PLoS), 2022)
    Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process ...