Browsing by Author "Martín Caballero, Juan"

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  • Aged stem cells reprogram their daily rhythmic functions to adapt to stress
    Solanas, Guiomar; Oliveira Peixoto, Francisca; Perdiguero, Eusebio, 1968-; Jardí, Mercè; Ruiz Bonilla, Vanesa, 1979-; Datta, Debayan; Symeonidi, Aikaterini; Castellanos, Andrés; Welz, Patrick-Simon; Martín Caballero, Juan; Sassone-Corsi, Paolo; Muñoz Cánoves, Pura, 1962-; Aznar Benitah, Salvador (Elsevier, 2017)
    Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their ...
  • Chimeric infectious bursal disease virus-like particles as potent vaccines for eradication of established HPV-16 E7-dependent tumors
    Martín Caballero, Juan; Garzón, Ana; González-Cintado, Leticia; Kowalczyk, Wioleta; Jiménez Torres, Ignacio; Calderita, Gloria; Rodríguez, Margarita; Gondar, Virgínia; Bernal, Juan Jose; Ardavín, Carlos; Andreu Martínez, David; Zürcher, Thomas; Kobbe, Cayetano von (Public Library of Science (PLoS), 2012)
    Cervical cancer is caused by persistent high-risk human papillomavirus (HR-HPV) infection and represents the second most frequent gynecological malignancy in the world. The HPV-16 type accounts for up to 55% of all cervical ...
  • Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility
    Núñez Ollé, Marc, 1984-; Jung, Carole; Terré, Berta; Balsiger, Norman A.; Plata, Cristina; Roset i Huguet, Ramon; Pardo Pastor, Carlos; Garrido, Marta; Rojas, Santiago; Alameda Quitllet, Francisco; Lloreta Trull, Josep, 1958-; Martín Caballero, Juan; Flores, Juana M.; Stracker, Travis; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964-; Gil Gómez, Gabriel (Impact Journals, 2017)
    Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple ...
  • Direct interaction between Id1 and Zrf1 controls neural differentiation of embryonic stem cells
    Aloia, Luigi; Gutiérrez, Arantxa; Martín Caballero, Juan; Di Croce, Luciano (Wiley-Blackwell, 2015)
    Id proteins are dominant-negative regulators within the HLH family of proteins. In embryonic stem cells (ESCs), Id1 and Id3 maintain the pluripotent state by preventing neural differentiation. The Id1-interacting protein ...
  • Identity noise and adipogenic traits characterize dermal fibroblast aging
    Aznar Benitah, Salvador; Lafzi, Atefeh; Berenguer-Llergo, Antonio; Youssif, Catrin; Castellanos, Andrés; Solanas, Guiomar; Peixoto, Francisca Oliveira; Stephan-Otto Attolini, Camille; Prats, Neus; Aguilera, Mònica; Martín Caballero, Juan; Heyn, Holger; Aznar Benitah, Salvador (Elsevier, 2018)
    During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we ...
  • Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5
    Buxadé Fortuny, Maria; Huerga Encabo, Hector, 1989-; Riera-Borrull, Marta; Quintana-Gallardo, Lucía; López-Cotarelo, Pilar; Tellechea Recarte, Mónica, 1989-; Martínez-Martínez, Sara; Redondo, Juan Miguel; Martín Caballero, Juan; Flores, Juana M.; Bosch Fusté, Elena; Rodríguez-Fernández, José Luis; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2018)
    MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses. Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type-specific promoters. ...
  • Understanding functional interplay between PARP-1 and PARP-2 in T cell development and function
    Navarro Serer, Judith, 1990- (Universitat Pompeu Fabra, 2016-12-15)
    T-cell homeostasis must be tightly regulated and maintained in order to guarantee appropriate immune responses and prevent immunopathology. This maintenance depends on MHC-TCR interaction and cytokine-mediated signals among ...