Browsing by Author "Marrugat de la Iglesia, Jaume"

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  • A century of trends in adult human height
    NCD Risk Factor Collaboration (NCD-RisC); Álvarez Pedrerol, Mar; Marrugat de la Iglesia, Jaume; Porta Serra, Miquel; Sunyer Deu, Jordi (eLife, 2016)
    Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height ...
  • A European benchmarking system to evaluate in-hospital mortality rates in acute coronary syndrome: The EURHOBOP project.
    Dégano, Irene R.; Subirana Cachinero, Isaac; Torre, Marina; Grau Magaña, Maria; Vila, Joan; Fusco, Danilo; Kirchberger, Inge; Ferrières, Jean; Malmivaara, Antti; Azevedo, Ana; Meisinger, Christa; Bongard, Vanina; Farmakis, Dimitrios; Davoli, Marina; Häkkinen, Unto; Araújo, Carla; Lekakis, John; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume (Elsevier, 2015)
    BACKGROUND: Hospital performance models in acute myocardial infarction (AMI) are useful to assess patient management. While models are available for individual countries, mainly US, cross-European performance models are ...
  • Association between long-term air pollution exposure and DNA methylation: The REGICOR study
    Sayols, Sergi; Fernández Sanlés, Alba, 1988-; Prats Uribe, Albert; Subirana Cachinero, Isaac; Plusquin, Michelle; Künzli, Nino; Marrugat de la Iglesia, Jaume; Basagaña Flores, Xavier; Elosua Llanos, Roberto (Elsevier, 2019)
    INTRODUCTION: Limited evidence suggests that epigenetic mechanisms may partially mediate the adverse effects of air pollution on health. Our aims were to identify new genomic loci showing differential DNA methylation ...
  • Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study
    Rivera, Marcela, 1982-; Basagaña Flores, Xavier; Aguilera Jiménez, Inmaculada, 1977-; Foraster Pulido, Maria, 1984-; Agis, David; Groot, Eric de; Pérez Grau, Laura; Mendez, Michelle A.; Bouso, Laura; Targa, Jaume; Ramos, Rafel; Sala, Joan; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto; Künzli, Nino (National Institute of Environmental Health Sciences (NIEHS), 2013)
    BACKGROUND: Epidemiological evidence of the effects of long-term exposure to air pollution on the chronic processes of atherogenesis is limited. OBJECTIVE: We investigated the association of long-term exposure to traffic-related ...
  • Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: the REGICOR Study
    Dégano, Irene R.; Camps-Vilaró, Anna; Subirana Cachinero, Isaac; García-Mateo, Nadia; Cidad, Pilar; Muñoz Aguayo, Daniel; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Vila, Joan; Crepaldi, Felipe M.; Gonzalo-Calvo, David de; Llorente-Cortés, Vicenta; Pérez García, María Teresa; Elosua Llanos, Roberto; Fitó Colomer, Montserrat; Marrugat de la Iglesia, Jaume (MDPI, 2020)
    Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine ...
  • Association of kidney disease, potassium, and cardiovascular risk factor prevalence with coronary arteriosclerotic burden, by sex
    Maragaño Lizama, Patricio; Ríos, Diana L.; Subirana Cachinero, Isaac; Toloba, Andrea; Camps-Vilaró, Anna; Belzares, Oward; Pacheco, Claudio; Cerro, Cristina; Wehinger, Sergio; Fuentes, Eduardo; Marrugat de la Iglesia, Jaume; Palomo, Iván (MDPI, 2021)
    The present study aimed to determine the relationship between the prevalence of cardiovascular risk factors and the number and severity of coronary artery atherosclerotic lesions obtained by coronary angiography. We reviewed ...
  • Association of long-term exposure to traffic-related air pollution with blood pressure and hypertension in an adult population-based cohort in Spain (the REGICOR study)
    Foraster Pulido, Maria, 1984-; Basagaña Flores, Xavier; Aguilera Jiménez, Inmaculada, 1977-; Rivera, Marcela, 1982-; Agis, David; Bouso, Laura; Deltell, Alexandre; Marrugat de la Iglesia, Jaume; Ramos, Rafel; Sunyer Deu, Jordi; Vila, Joan; Elosua Llanos, Roberto; Künzli, Nino (National Institute of Environmental Health Sciences (NIEHS), 2014)
    Background: Long-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension. However, evidence supporting these associations is limited, and they may be confounded by exposure ...
  • Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction
    Fernández-Bergés, Daniel; Dégano, Irene R.; Subirana Cachinero, Isaac; Martí-Almor, Julio; Vila, Joan; Pérez-Fernández, Silvia; Martí-Almor, Julio; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; ATHOS investigators (BMJ Publishing Group, 2020)
    Objective: Primary percutaneous coronary intervention (P-PCI) has demonstrated its efficacy in patients with ST segment elevation myocardial infarction (STEMI). However, patients with STEMI ≥75 years receive less P-PCI ...
  • Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater Than the Parts? A Genetic Approach
    Elosua Llanos, Roberto; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin, 1977-; Sayols, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí Clapés, Mariano; Siscovick, David; Mellander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat de la Iglesia, Jaume (Lippincott Williams & Wilkins, 2016)
    BACKGROUND: Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk ...
  • Cholesterol and hypertension treatment improve coronary risk prediction but not time-dependent covariates or competing risks
    Subirana Cachinero, Isaac; Camps-Vilaró, Anna; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; Tizón-Marcos, Helena; Palomo, Iván; Dégano, Irene R. (Dove Medical Press, 2022)
    Background and aims: cardiovascular (CV) risk functions are the recommended tool to identify high-risk individuals. However, their discrimination ability is not optimal. While the effect of biomarkers in CV risk prediction ...
  • DNA methylation biomarkers of myocardial infarction and cardiovascular disease
    Fernández Sanlés, Alba, 1988-; Sayols Baixeras, Sergi, 1988-; Subirana Cachinero, Isaac; Sentí Clapés, Mariano; Pérez-Fernández, Silvia; Castro de Moura, Manuel; Esteller, Manel; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (BioMed Central, 2021)
    Background: The epigenetic landscape underlying cardiovascular disease (CVD) is not completely understood and the clinical value of the identified biomarkers is still limited. We aimed to identify differentially methylated ...
  • Do individuals with autoimmune disease have increased risk of subclinical carotid atherosclerosis and stiffness?
    Vila, M. Mar; Remeseiro, Beatriz; Igual, Laura; Elosua Llanos, Roberto; Ramos, Rafel; Valdivielso, Jose Manuel; Martí-Lluch, Ruth; Marrugat de la Iglesia, Jaume (Nature Research, 2021)
    To explore the role of chronic inflammation inherent to autoimmune diseases in the development of subclinical atherosclerosis and arterial stiffness, this study recruited two population-based samples of individuals with ...
  • Early smoking-onset age and risk of cardiovascular disease and mortality
    Fa-Binefa, Manel; Clará Velasco, Alberto; Pérez-Fernández, Silvia; Grau Magaña, Maria; Dégano, Irene R.; Martí-Lluch, Ruth; Ramos, Rafel; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (Elsevier, 2019)
    Early smoking onset age (SOA) is a public health concern with scant empirical evidence of its role in health outcomes. The study had two aims: i) to assess whether an early SOA was associated with the risk of fatal and ...
  • Effectiveness of statins as prevention in people with gout: a population-based cohort study
    Garcia Gil, Maria; Comas Cufí, Marc; Ramos, Rafel; Martí, Ruth; Alves-Cabratosa, Lia; Parramon, Dídac; Prieto-Alhambra, Daniel; Baena Díez, Jose M.; Salvador-González, Betlem; Elosua Llanos, Roberto; Dégano, Irene R.; Marrugat de la Iglesia, Jaume; Grau Magaña, Maria (SAGE Publications, 2019)
    Background: Cardiovascular guidelines do not give firm recommendations on statin therapy in patients with gout because evidence is lacking. Aim: To analyze the effectiveness of statin therapy in primary prevention of ...
  • Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.
    Cuadrado-Godia, Elisa; Regueiro, Ander; Núñez, Julio; Díaz-Ricard, Maribel; Novella, Susana; Oliveras, Anna; Valverde, M. A. (Miguel Ángel), 1963-; Marrugat de la Iglesia, Jaume; Ois Santiago, Angel Javier; Giralt-Steinhauer, Eva; Sanchís, Juan; Escolar, Ginès; Hermenegildo, Carlos; Heras, Magda; Roquer, Jaume (Public Library of Science, 2015)
    INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested ...
  • Estimated population prevalence of heart failure with reduced ejection fraction in Spain, according to DAPA-HF Study Criteria
    Camps-Vilaró, Anna; Delgado-Jiménez, Juan F.; Farré López, Núria; Tizón-Marcos, Helena; Álvarez-García, Jesus; Cinca, Juan; Dégano, Irene R.; Marrugat de la Iglesia, Jaume (MDPI, 2020)
    Heart failure (HF) is one of the main causes of morbidity, mortality, and high healthcare costs. Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reduced cardiovascular mortality and hospitalization for ...
  • Familial hypercholesterolemia in a European Mediterranean population-Prevalence and clinical data from 2.5 million primary care patients
    Zamora, Alberto; Masana, Luís; Comas Cufí, Marc; Vila, Alex; Plana, Nuria; Garcıa-Gil, Maria; Alves-Cabratosa, Lia; Marrugat de la Iglesia, Jaume; Roman Degano, Irene; Ramos, Rafel; XULA and ISV-Girona groups (Elsevier, 2017)
    BACKGROUND: Familial hypercholesterolemia (FH), the most frequent hereditary cause of premature coronary heart disease (CHD), is underdiagnosed and insufficiently treated. OBJECTIVES: The objectives of the study were to ...
  • Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension
    Fernández-Fernández, José Manuel, 1967-; Tomás Mestres, Marta; Vázquez Gómez, Esther; Orio, Patricio; Latorre, Ramón; Sentí Clapés, Mariano; Marrugat de la Iglesia, Jaume; Valverde, M. A. (Miguel Ángel), 1963- (American Society for Clinical Investigation, 2004)
    Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca(2+)-dependent K(+) (BK) channel. The ...
  • Gender analysis of the frequency and course of depressive disorders and relationship with personality traits in general population: A prospective cohort study
    Serrano, Domènec; Martí-Lluch, Ruth; Cárdenas, Mérida; Solanas, Pascual; Marrugat de la Iglesia, Jaume; Vilalta-Franch, Joan; Garre-Olmo, Josep (Elsevier, 2022)
    Background: We aimed to determine the prevalence and course of subthreshold depressive symptomatology (sDS) and probable major depressive episode (MDE) and to examine their association with personality traits among men and ...
  • High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study
    Prats Uribe, Albert; Sayols Baixeras, Sergi, 1988-; Fernández Sanlés, Alba, 1988-; Subirana Cachinero, Isaac; Carreras-Torres, Robert; Vilahur, Gemma; Civeira, Fernando; Marrugat de la Iglesia, Jaume; Fitó Colomer, Montserrat; Hernáez, Álvaro; Elosua Llanos, Roberto (Elsevier, 2020)
    Background: To assess whether genetically determined quantitative and qualitative HDL characteristics were independently associated with coronary artery disease (CAD). Methods: We designed a two-sample multivariate Mendelian ...