Browsing by Author "Marruecos, Laura"

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  • Brena, David; Bertran, Joan; Porta de la Riva, Montserrat; Guillén, Yolanda; Cornes Maragliano, Eric, 1987-; Kukhtar, Dmytro; Campos-Vicens, Lluís; Fernández, Lierni; Pecharroman, Irene; García-López, Albert; Islam, Abul, 1978-; Marruecos, Laura; Bigas Salvans, Anna; Cerón Madrigal, Julián; Espinosa Blay, Lluís (Nature Research, 2020)
    Mammalian IκB proteins (IκBs) exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect ...
  • Marruecos, Laura; Bertran, Joan; Álvarez-Villanueva, Daniel; Mulero, María Carmen; Guillén, Yolanda; Palma, Luis G.; Floor, Martin; Vert, Anna; Arce-Gallego, Sara; Pecharroman, Irene; Batlle Masó, Laura, 1993-; Villà i Freixa, Jordi; Ghosh, Gourisankar; Bigas Salvans, Anna; Espinosa Blay, Lluís (Wiley, 2021)
    IκBs exert principal functions as cytoplasmic inhibitors of NF-kB transcription factors. Additional roles for IκB homologues have been described, including chromatin association and transcriptional regulation. Phosphorylated ...
  • Manils, Joan; Gómez, Diana; Salla-Martret, Mercè; Fischer, Heinz; Fye, Jason M.; Marzo, Elena; Marruecos, Laura; Serrano, Inma; Salgado, Rocío; Rodrigo, Juan P.; Garcia-Pedrero, Juana M.; Serafin, Anna M.; Cañas, Xavier; Benito, María del Carmen; Toll Abelló, Agustín; Forcales Fernàndez, Sonia-Vanina; Perrino, Fred W.; Eckhart, Leopold; Soler, Concepció (Impact Journals, 2015)
    TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic ...
  • Colomer Montañà, Carlota, 1990-; Marruecos, Laura; Vert, Anna; Bigas Salvans, Anna; Espinosa Blay, Lluís (MDPI, 2017)
    Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent ...
  • Espinosa Blay, Lluís (MDPI, 2021)
    IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, ...
  • Marruecos, Laura; Manils, Joan; Moreta, Cristina; Gómez, Diana; Filgaira, Ingrid; Serafín, Anna; Cañas, Xavier; Espinosa Blay, Lluís; Soler, Concepció (Nature Research, 2021)
    Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we ...

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