Browsing by Author "Marguerat, Samuel"

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  • Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters
    Robles-Rebollo, Irene; Cuartero, Sergi; Canellas-Socias, Adria; Wells, Sarah; Karimi, Mohammad M.; Mereu, Elisabetta; Chivu, Alexandra G.; Heyn, Holger; Whilding, Chad; Dormann, Dirk; Marguerat, Samuel; Rioja, Inmaculada; Prinjha, Rab K.; Stumpf, Michael P.H.; Fisher, Amanda G.; Merkenschlager, Matthias (Nature Research, 2022)
    Innate immune responses rely on inducible gene expression programmes which, in contrast to steady-state transcription, are highly dependent on cohesin. Here we address transcriptional parameters underlying this cohesin-dependence ...
  • Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
    Garcia-Diaz, Claudia; Pöysti, Anni; Mereu, Elisabetta; Clements, Melanie P.; Brooks, Lucy J.; Galvez-Cancino, Felipe; Castillo, Simon P.; Tang, Wenhao; Beattie, Gordon; Courtot, Lilas; Ruiz, Sara; Roncaroli, Federico; Yuan, Yinyin; Marguerat, Samuel; Quezada, Sergio A.; Heyn, Holger; Parrinello, Simona (Elsevier, 2023)
    Glioblastoma (GBM) recurrence originates from invasive margin cells that escape surgical debulking, but to what extent these cells resemble their bulk counterparts remains unclear. Here, we generated three immunocompetent ...

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