Browsing by Author "Manzanares, Miguel"

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  • An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms
    Tapial Rodríguez, Javier, 1990-; Ha, Kevin C. H.; Sterne-Weiler, Thimothy; Gohr, André; Braunschweig, Ulrich; Hermoso Pulido, Antonio; Quesnel-Vallières, Mathieu; Permanyer, Jon; Sodaei, Reza, 1988-; Marquez, Yamile; Cozzuto, Luca; Wang, Xinchen; Gómez-Velázquez, Melisa; Rayon, Teresa; Manzanares, Miguel; Ponomarenko, Julia; Blencowe, Benjamin J.; Irimia, Manuel (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    Alternative splicing (AS) generates remarkable regulatory and proteomic complexity in metazoans. However, the functions of most AS events are not known, and programs of regulated splicing remain to be identified. To address ...
  • Essential roles of cohesin STAG2 in mouse embryonic development and adult tissue homeostasis
    De Koninck, Magali; Lapi, Eleonora; Badía Careaga, Claudio; Cossío, Itziar; Giménez-Llorente, Daniel; Rodríguez-Corsino, Miriam; Andrada, Elena; Hidalgo, Andrés; Manzanares, Miguel; Real, Francisco X.; Losada, Ana (Elsevier, 2020)
    Cohesin mediates sister chromatid cohesion and 3D genome folding. Two versions of the complex carrying STAG1 or STAG2 coexist in somatic vertebrate cells. STAG2 is commonly mutated in cancer, and germline mutations have ...
  • The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1
    Sainz de Aja, Julio; Menchero, Sergio; Rollan, Isabel; Barral, Antonio; Tiana, Maria; Jawaid, Wajid; Cossio, Itziar; Alvarez, Alba; Carreño-Tarragona, Gonzalo; Badia-Careaga, Claudio; Nichols, Jennifer; Göttgens, Berthold; Isern, Joan; Manzanares, Miguel (EMBO Press, 2019)
    Progenitors of the first hematopoietic cells in the mouse arise in the early embryo from Brachyury-positive multipotent cells in the posterior-proximal region of the epiblast, but the mechanisms that specify primitive blood ...