Browsing by Author "Malhotra, Vivek"

Sort by: Order: Results:

  • Blume, Julia von; Alleaume, Anne-Marie; Cantero Recasens, Gerard, 1984-; Curwin, Amy; Carreras Sureda, Amado, 1986-; Zimmermann, Timo; Galen, Josse van; Wakana, Yuichi; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (Elsevier, 2011)
    Actin-severing proteins ADF/cofilin are required for the sorting of secretory cargo at the trans-Golgi network (TGN) in mammalian cells. How do these cytoplasmic proteins interact with the cargoes in the lumen of the TGN? ...
  • Blume, Julia von; Alleaume, Anne-Marie; Kienzle, Christine; Carreras Sureda, Amado, 1986-; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (Rockefeller University Press, 2012)
    Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is ...
  • Curwin, Amy; Blume, Julia von; Malhotra, Vivek (American Society for Cell Biology, 2012)
    The mechanism of cargo sorting at the trans-Golgi network (TGN) for secretion is poorly understood. We previously reported the involvement of the actin-severing protein cofilin and the Ca(2+) ATPase secretory pathway calcium ...
  • Curwin, Amy; Brouwers, Nathalie; Alonso Y Adell, Manuel; Teis, David; Turacchio, Gabriele; Parashuraman, Seetharaman; Ronchi, Paolo; Malhotra, Vivek (eLife, 2016)
    The unconventional secretory pathway exports proteins that bypass the endoplasmic reticulum. In Saccharomyces cerevisiae, conditions that trigger Acb1 secretion via this pathway generate a Grh1 containing compartment ...
  • Chiritoiu, Marioara; Brouwers, Nathalie; Turacchio, Gabriele; Pirozzi, Marianella; Malhotra, Vivek (Elsevier, 2019)
    Signal-sequence-lacking interleukin (IL)-1β, is cleaved by caspase-1 to mature mIL-1β, which is secreted, without entering the endoplasmic reticulum. We report that macrophages of GRASP55-/- mice are defective in mIL-1β ...
  • Bruns, Caroline, 1984- (Universitat Pompeu Fabra, 2013-04-30)
    A part de la secreció convencional, en la qual les proteïnes són transportades a través del reticle endoplasmàtic (RE) i de l'aparell de Golgi, s'han descrit, per a diferents proteïnes i en organismes diversos, rutes de ...
  • Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Valverde, M. A. (Miguel Ángel), 1963-; Naranjo, José R.; Brouwers, Nathalie; Malhotra, Vivek (eLife, 2018)
    Regulated mucin secretion from specialized goblet cells by exogenous agonist-dependent (stimulated) and -independent (baseline) manner is essential for the function of the epithelial lining. Over extended periods, baseline ...
  • Wakana, Yuichi; Villeneuve, Julien; Galen, Josse van; Cruz Garcia, David; Tagaya, Mitsuo; Malhotra, Vivek (Rockefeller University Press, 2013)
    Here we report that the kinesin-5 motor Klp61F, which is known for its role in bipolar spindle formation in mitosis, is required for protein transport from the Golgi complex to the cell surface in Drosophila S2 cells. ...
  • Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Brouwers, Nathalie; Mitrovic, Sandra; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (American Society for Biochemistry and Molecular Biology (ASBMB), 2019)
    Regulated mucin secretion is essential for the formation of the mucus layer that protects the underlying epithelial cells from foreign particles. Alterations in the quantity or quality of secreted mucins are therefore ...
  • Campelo, Felix; van Galen, Josse; Turacchio, Gabriele; Parashuraman, Seetharaman; Kozlov, Michael M.; García Parajó, María F.; Malhotra, Vivek (eLife, 2017)
    The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how is this morphology achieved and is it related to its function in cargo sorting and export? A physical model of cisterna morphology led us ...
  • Santos, António J. M.; Nogueira, Cristina; Ortega Bellido, María; Malhotra, Vivek (Rockefeller University Press, 2016)
    Procollagens, pre-chylomicrons, and pre–very low-density lipoproteins (pre-VLDLs) are too big to fit into conventional COPII-coated vesicles, so how are these bulky cargoes exported from the endoplasmic reticulum (ER)? We ...
  • Ashok, Anupama, 1985- (Universitat Pompeu Fabra, 2019-01-21)
    COPII vesicles of 60-90nm diameter are known to export secretory cargoes from endoplasmic reticulum (ER). However, they cannot be employed to export bulky cargoes like the collagens that can reach up to 400 nm in length. ...
  • Raote, Ishier; Ortega Bellido, María; Pirozzi, Marianella; Zhang, Chong; Melville, David; Parashuraman, Seetharaman; Zimmermann, Timo; Malhotra, Vivek (Rockefeller University Press, 2017)
    TANGO1 (transport and Golgi organization 1) interacts with CTAGE5 and COPII components Sec23/Sec24 and recruits ERGIC-53 (endoplasmic reticulum [ER]–Golgi intermediate compartment 53)–containing membranes to generate a ...
  • Raote, Ishier; Ortega Bellido, María; Santos, António J. M.; Foresti, Ombretta; Zhang, Chong; García Parajó, María F.; Campelo, Felix; Malhotra, Vivek (eLife, 2018)
    Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky ...
  • Mitrovic, Sandra; Nogueira, Cristina; Cantero Recasens, Gerard, 1984-; Kiefer, Kerstin, 1986-; Fernández-Fernández, José Manuel, 1967-; Popoff, Jean-François; Casano, Laetitia; Bard, Frederic A.; Gómez, Raul; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (eLife, 2013)
    Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic ...