Browsing by Author "Maldonado, Rafael, 1961-"

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  • Martin, Cedric B.P.; Martín, Vicente; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • Martin, Cedric B.P.; Martin, Vincent S.; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • Martin, Cedric B.P.; Martin, Vincent S.; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    BACKGROUND: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • Cajiao-Manrique, María Del Mar; Maldonado, Rafael, 1961-; Martín García, Elena, 1975- (Frontiers, 2023)
    We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C57Bl/6J mice. This model allows to evaluate the addiction criteria ...
  • Chung, Paul Chu Sin; Keyworth, Helen L.; Martín García, Elena, 1975-; Charbogne, Pauline; Darcq, Emmanuel; Bailey, Alexis; Filliol, Dominique; Matifas, Audrey; Scherrer, Grégory; Ouagazzal, Abdel-Mouttalib; Gaveriaux-Ruff, Claire; Befort, Katia; Maldonado, Rafael, 1961-; Kitchen, Ian; Kieffer, Brigitte L. (Elsevier, 2015)
    BACKGROUND: The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underlying DOR activities have been ...
  • Torre Fornell, Rafael de la; De Sola Llopis, Susana; Xicota Vila, Laura, 1987-; Cuenca Royo, Aida Ma, 1981-; Rodriguez, Joan; Gomis González, Maria, 1988-; Hernández, Gimena; Del Hoyo Soriano, Laura; Ozaita Mintegui, Andrés, 1969-; Dierssen, Mara; TESXF Study Group; Principe, Alessandro; Espadaler, Josep María; Roca, Laia; Del Hoyo Soriano, Laura; Farré Albaladejo, Magí; Fitó Colomer, Montserrat; León Jorba, Alba; Banea, Ovideo; Maldonado, Rafael, 1961-; Busquets Garcia, Arnau, 1985- (Elsevier, 2020)
    Background & aims: Despite the wide spectrum of experimental compounds tested in clinical trials, there is still no proven pharmacological treatment available for Fragile-X syndrome (FXS), since several targeted clinical ...
  • Plaza-Zabala, Ainhoa, 1982-; Flores de los Heros, África, 1985-; Martín García, Elena, 1975-; Saravia Santos, Rocio, 1988-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Nature Publishing Group, 2013)
    Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin system in the reinstatement of nicotine-seeking behavior induced by ...
  • Domingo Rodriguez, Laura, 1992-; Ruiz de Azua, Iñigo; Domínguez, Eduardo; Senabre, Eric; Serra, Irene; Kummer, Sami, 1985-; Navandar, Mohit; Baddenhausen, Sarah; Hofmann, Clementine; Andero, Raül; Gerber, Susanne; Navarrete, Marta; Dierssen, Mara; Lutz, Beat; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Nature Research, 2020)
    Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid ...
  • Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, Patricia, 1958-; Hahn, Heidi; Valverde Granados, Olga; Maldonado, Rafael, 1961- (Society for Neuroscience, 2001)
    The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
  • Grau Cerrato, Santiago; Ferrández, Olivia; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (MDPI, 2021)
  • Fernández Castillo, Noelia; Orejarena Serrano, María-Juliana, 1980-; Ribasés, Marta; Casas, Miguel; Robledo, Patricia, 1958-; Maldonado, Rafael, 1961-; Cormand, Bru (Wiley-Blackwell, 2012)
    3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a recreational drug widely used by adolescents and young adults. Although its rewarding effects are well established, there is controversy on its addictive potential. ...
  • Matthes, Hans W. D.; Smadja, C.; Valverde Granados, Olga; Vonesch, J. L.; Foutz, A. S.; Boudinot, Eliane; Denavit-Saubié, M.; Severini, Cintia; Negri, Lucia; Roques, Bernard P.; Maldonado, Rafael, 1961-; Kieffer, Brigitte L. (Society for Neuroscience, 1998)
    Previous pharmacological studies have indicated the possible existence of functional interactions between μ-, δ- and κ-opioid receptors in the CNS. We have investigated this issue using a genetic approach. Here we describe ...
  • Szerman, Nestor; Torrens, Marta; Maldonado, Rafael, 1961-; Balhara, Yatan Pal Singh; Salom, Caroline; Maremmani, Icro; Sher, Leo; Didia-Attas, Javier; Chen, Jun; Baler, Ruben; World Association on Dual Disorders (WADD) (Nature Research, 2022)
    The persistent difficulty in conceptualizing the relationship between addictive and other mental disorders stands out among the many challenges faced by the field of Psychiatry. The different philosophies and schools of ...
  • Oliveras Cañellas, Núria; Castells-Nobau, Anna; Vega-Correa, Lisset de la; Latorre-Luque, Jessica; Motger-Albertí, Anna; Arnoriaga Rodríguez, María; Garre-Olmo, Josep; Zapata-Tona, Cristina; Coll Martínez, Clàudia; Ramió-Torrentà, Lluís; Moreno-Navarrete, José Maria; Puig, Josep; Villarroya, Francesc; Ramos, Rafel; Casadó-Anguera, Verònica; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Mayneris Perxachs, Jordi; Fernández Real, Jose M. (American Association for the Advancement of Science (AAAS), 2023)
    Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)-brain axis. We identified 188 genes from RNA sequencing of AT in three cohorts that were associated with performance ...
  • Ten-Blanco, Marc; Flores de los Heros, África, 1985-; Pereda-Pérez, Inmaculada; Piscitelli, Fabiana; Izquierdo-Luengo, Cristina; Cristino, Luigia; Romero, Julián; Hillard, Cecilia J.; Maldonado, Rafael, 1961-; Di Marzo, Vicenzo; Berrendero Díaz, Fernando, 1971- (Elsevier, 2022)
    Anxiety and stress disorders are often characterized by an inability to extinguish learned fear responses. Orexins/hypocretins are involved in the modulation of aversive memories, and dysregulation of this system may ...
  • Plaza-Zabala, Ainhoa, 1982-; Li, Xuan; Milovanovic, Mike; Loweth, Jessica A.; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971-; Wolf, Marina E. (Elsevier, 2013)
    Hypocretin peptides are critical for the effects of cocaine on excitatory synaptic strength in the ventral tegmental area (VTA). However, little is known about their role in cocaine-induced synaptic plasticity in the nucleus ...
  • Saravia Santos, Rocio, 1988-; Ten-Blanco, Marc; Grande, María T.; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2019)
    Nicotine withdrawal is associated with cognitive deficits including attention, working memory, and episodic memory impairments. These cognitive deficits are a hallmark of nicotine abstinence which could be targeted in order ...
  • Varani, Andrés P.; Aso Pérez, Ester; Machado Moutinho, Lirane; Maldonado, Rafael, 1961-; Balerio, Graciela N. (Springer, 2014)
    RATIONALE: Nicotine is a major active ingredient in tobacco and plays a major role in tobacco addiction. In rodents, repeated nicotine administration produces behavioral responses related to its addictive properties, such ...
  • Berrendero Díaz, Fernando, 1971-; Kieffer, Brigitte L.; Maldonado, Rafael, 1961- (Society for Neuroscience, 2002)
    The involvement of μ-opioid receptors in different behavioral responses elicited by nicotine was explored by using μ-opioid receptor knock-out mice. The acute antinociceptive responses induced by nicotine in the tail-immersion ...
  • Brambilla Pisoni, Cecilia, 1993-; Muñoz-Moreno, Emma; Gallego-Amaro, Ianire; Maldonado, Rafael, 1961-; Ivorra Cano, Antoni, 1974-; Soria Rodríguez, Guadalupe; Ozaita Mintegui, Andrés, 1969- (Frontiers, 2022)
    Brain electrical stimulation techniques take advantage of the intrinsic plasticity of the nervous system, opening a wide range of therapeutic applications. Vagus nerve stimulation (VNS) is an approved adjuvant for ...

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