Browsing by Author "Maldonado, Rafael, 1961-"

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  • 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence
    Martin, Cedric B.P.; Martin, Vincent S.; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    BACKGROUND: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence
    Martin, Cedric B.P.; Martin, Vincent S.; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence
    Martin, Cedric B.P.; Martín, Vicente; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • A male mouse model of WIN 55,212-2 self-administration to study cannabinoid addiction
    Cajiao-Manrique, María Del Mar; Maldonado, Rafael, 1961-; Martín García, Elena, 1975- (Frontiers, 2023)
    We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C57Bl/6J mice. This model allows to evaluate the addiction criteria ...
  • A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons
    Chung, Paul Chu Sin; Keyworth, Helen L.; Martín García, Elena, 1975-; Charbogne, Pauline; Darcq, Emmanuel; Bailey, Alexis; Filliol, Dominique; Matifas, Audrey; Scherrer, Grégory; Ouagazzal, Abdel-Mouttalib; Gaveriaux-Ruff, Claire; Befort, Katia; Maldonado, Rafael, 1961-; Kitchen, Ian; Kieffer, Brigitte L. (Elsevier, 2015)
    BACKGROUND: The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underlying DOR activities have been ...
  • A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome
    Torre Fornell, Rafael de la; De Sola Llopis, Susana; Xicota Vila, Laura, 1987-; Cuenca Royo, Aida Ma, 1981-; Rodriguez, Joan; Gomis González, Maria, 1988-; Hernández, Gimena; Del Hoyo Soriano, Laura; Ozaita Mintegui, Andrés, 1969-; Dierssen, Mara; TESXF Study Group; Principe, Alessandro; Espadaler, Josep María; Roca, Laia; Del Hoyo Soriano, Laura; Farré Albaladejo, Magí; Fitó Colomer, Montserrat; León Jorba, Alba; Banea, Ovideo; Maldonado, Rafael, 1961-; Busquets Garcia, Arnau, 1985- (Elsevier, 2020)
    Background & aims: Despite the wide spectrum of experimental compounds tested in clinical trials, there is still no proven pharmacological treatment available for Fragile-X syndrome (FXS), since several targeted clinical ...
  • A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior
    Plaza-Zabala, Ainhoa, 1982-; Flores de los Heros, África, 1985-; Martín García, Elena, 1975-; Saravia Santos, Rocio, 1988-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Nature Publishing Group, 2013)
    Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin system in the reinstatement of nicotine-seeking behavior induced by ...
  • A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction
    Domingo Rodriguez, Laura, 1992-; Ruiz de Azua, Iñigo; Domínguez, Eduardo; Senabre, Eric; Serra, Irene; Kummer, Sami, 1985-; Navandar, Mohit; Baddenhausen, Sarah; Hofmann, Clementine; Andero, Raül; Gerber, Susanne; Navarrete, Marta; Dierssen, Mara; Lutz, Beat; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Nature Research, 2020)
    Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid ...
  • Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice
    Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, Patricia, 1958-; Hahn, Heidi; Valverde Granados, Olga; Maldonado, Rafael, 1961- (Society for Neuroscience, 2001)
    The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
  • Accidental interruption of the cold chain for the preservation of the moderna COVID-19 vaccine
    Grau Cerrato, Santiago; Ferrández, Olivia; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (MDPI, 2021)
  • Active and passive MDMA ('ecstasy') intake induces differential transcriptional changes in the mouse brain
    Fernández Castillo, Noelia; Orejarena Serrano, María-Juliana, 1980-; Ribasés, Marta; Casas, Miguel; Robledo, Patricia, 1958-; Maldonado, Rafael, 1961-; Cormand, Bru (Wiley-Blackwell, 2012)
    3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a recreational drug widely used by adolescents and young adults. Although its rewarding effects are well established, there is controversy on its addictive potential. ...
  • Activity of the δ-Opioid Receptor Is Partially Reduced, Whereas Activity of the κ-Receptor Is Maintained in Mice Lacking the μ-Receptor
    Matthes, Hans W. D.; Smadja, C.; Valverde Granados, Olga; Vonesch, J. L.; Foutz, A. S.; Boudinot, Eliane; Denavit-Saubié, M.; Severini, Cintia; Negri, Lucia; Roques, Bernard P.; Maldonado, Rafael, 1961-; Kieffer, Brigitte L. (Society for Neuroscience, 1998)
    Previous pharmacological studies have indicated the possible existence of functional interactions between μ-, δ- and κ-opioid receptors in the CNS. We have investigated this issue using a genetic approach. Here we describe ...
  • Addictive and other mental disorders: a call for a standardized definition of dual disorders
    Szerman, Nestor; Torrens, Marta; Maldonado, Rafael, 1961-; Balhara, Yatan Pal Singh; Salom, Caroline; Maremmani, Icro; Sher, Leo; Didia-Attas, Javier; Chen, Jun; Baler, Ruben; World Association on Dual Disorders (WADD) (Nature Research, 2022)
    The persistent difficulty in conceptualizing the relationship between addictive and other mental disorders stands out among the many challenges faced by the field of Psychiatry. The different philosophies and schools of ...
  • Adipose tissue coregulates cognitive function
    Oliveras Cañellas, Núria; Castells-Nobau, Anna; Vega-Correa, Lisset de la; Latorre-Luque, Jessica; Motger-Albertí, Anna; Arnoriaga Rodríguez, María; Garre-Olmo, Josep; Zapata-Tona, Cristina; Coll Martínez, Clàudia; Ramió-Torrentà, Lluís; Moreno-Navarrete, José Maria; Puig, Josep; Villarroya, Francesc; Ramos, Rafel; Casadó-Anguera, Verònica; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Mayneris Perxachs, Jordi; Fernández Real, Jose M. (American Association for the Advancement of Science (AAAS), 2023)
    Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)-brain axis. We identified 188 genes from RNA sequencing of AT in three cohorts that were associated with performance ...
  • Affective disorders and neuropathic pain as mutually influential factors : contribution of the opioid system
    Martínez Navarro, Miriam, 1990- (Universitat Pompeu Fabra, 2019-02-27)
    La alta variabilidad interindividual en las manifestaciones de dolor neuropático puede conducir a una respuesta diferencial de los pacientes a los tratamientos, y sugiere la idoneidad de terapias más personalizadas en lugar ...
  • Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1
    Ten-Blanco, Marc; Flores de los Heros, África, 1985-; Pereda-Pérez, Inmaculada; Piscitelli, Fabiana; Izquierdo-Luengo, Cristina; Cristino, Luigia; Romero, Julián; Hillard, Cecilia J.; Maldonado, Rafael, 1961-; Di Marzo, Vicenzo; Berrendero Díaz, Fernando, 1971- (Elsevier, 2022)
    Anxiety and stress disorders are often characterized by an inability to extinguish learned fear responses. Orexins/hypocretins are involved in the modulation of aversive memories, and dysregulation of this system may ...
  • An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure
    Plaza-Zabala, Ainhoa, 1982-; Li, Xuan; Milovanovic, Mike; Loweth, Jessica A.; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971-; Wolf, Marina E. (Elsevier, 2013)
    Hypocretin peptides are critical for the effects of cocaine on excitatory synaptic strength in the ventral tegmental area (VTA). However, little is known about their role in cocaine-induced synaptic plasticity in the nucleus ...
  • Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice
    Saravia Santos, Rocio, 1988-; Ten-Blanco, Marc; Grande, María T.; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2019)
    Nicotine withdrawal is associated with cognitive deficits including attention, working memory, and episodic memory impairments. These cognitive deficits are a hallmark of nicotine abstinence which could be targeted in order ...
  • Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations
    Varani, Andrés P.; Aso Pérez, Ester; Machado Moutinho, Lirane; Maldonado, Rafael, 1961-; Balerio, Graciela N. (Springer, 2014)
    RATIONALE: Nicotine is a major active ingredient in tobacco and plays a major role in tobacco addiction. In rodents, repeated nicotine administration produces behavioral responses related to its addictive properties, such ...
  • Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice
    Berrendero Díaz, Fernando, 1971-; Kieffer, Brigitte L.; Maldonado, Rafael, 1961- (Society for Neuroscience, 2002)
    The involvement of μ-opioid receptors in different behavioral responses elicited by nicotine was explored by using μ-opioid receptor knock-out mice. The acute antinociceptive responses induced by nicotine in the tail-immersion ...

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