Browsing by Author "Maitre, Léa"

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  • Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview
    Vrijheid, Martine; Basagaña Flores, Xavier; Gonzalez, Juan Ramon; Porcel, Joana; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Dadvand, Payam; Fossati, Serena; Guxens Junyent, Mònica; Maitre, Léa; Nieuwenhuijsen, Mark J.; Ortiz, Rodney; Stratakis, Nikos; Sunyer Deu, Jordi; Slama, Rémy (Wolters Kluwer (LWW), 2021)
    Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing ...
  • Applying the exposome concept in birth cohort research: a review of statistical approaches
    Santos, Susana; Maitre, Léa; Warembourg, Charline; Agier, Lydiane; Richiardi, Lorenzo; Basagaña Flores, Xavier; Vrijheid, Martine (Springer, 2020)
    The exposome represents the totality of life course environmental exposures (including lifestyle and other non-genetic factors), from the prenatal period onwards. This holistic concept of exposure provides a new framework ...
  • Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis
    Neumann, Alexander; Alemany, Silvia; González, Juan Ramón; Julvez, Jordi; Maitre, Léa; Sunyer Deu, Jordi; Guxens Junyent, Mònica; Tiemeier, Henning (Nature Research, 2020)
    Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is ...
  • Association of fish consumption and mercury exposure during pregnancy with metabolic health and inflammatory biomarkers in children
    Stratakis, Nikos; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Fossati, Serena; González Ruiz, Juan Ramón; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (JAMA Network, 2020)
    IMPORTANCE: The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. OBJECTIVE: To assess the associations of fish intake and mercury ...
  • Association of prenatal exposure to endocrine-disrupting chemicals with liver injury in children
    Midya, Vishal; Andrušaitytė, Sandra; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; Fossati, Serena; Gražulevičienė, Regina; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Valvi, Damaskini, 1983- (American Medical Association, 2022)
    Importance: Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the risk for liver injury in children; however, human evidence is scarce, and previous studies have not considered potential EDC-mixture ...
  • Characterizing the adult exposome in men and women from the general population: results from the EHES-LUX study
    Ruiz Castell, María de la Concepción, 1981-; Le Coroller, Gwenaëlle; Pexaras, Achilleas; Ciprián, Giovana M.; Fagherazzi, Guy; Bohn, Torsten; Maitre, Léa; Sunyer Deu, Jordi; Appenzeller, Brice M. R. (Elsevier, 2023)
    Throughout life individuals are exposed to a large array of diverse environmental exposures (exposome). Hair analyses can assess chronic exposure to a large number of chemicals with less intra-variability than urine and ...
  • Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: a panel study
    Fabbri, Lorenzo; Garlantézec, Ronan; Audouze, Karine; Bustamante Pineda, Mariona; Carracedo, Ángel; Chatzi, Leda; González, Juan Ramón; Gražulevičienė, Regina; Keun, Hector C.; Lau, Chung-Ho E.; Sabidó, Eduard; Siskos, Alexandros P.; Slama, Rémy; Thomsen, Cathrine; Wright, John; Yuan, Wen Lun; Casas, Maribel; Vrijheid, Martine; Maitre, Léa (Elsevier, 2023)
    Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused ...
  • Cord blood metabolic signatures predictive of childhood overweight and rapid growth
    Handakas, Evangelos; Keski-Rahkonen, Pekka; Chatzi, Leda; Alfano, Rossella; Roumeliotaki, Theano; Plusquin, Michelle; Maitre, Léa; Richiardi, Lorenzo; Brescianini, Sonia; Scalbert, Augustin; Robinot, Nivonirina; Nawrot, Tim S.; Sassi, Franco; Vrijheid, Martine; Vineis, Paolo; Robinson, Oliver (Nature Research, 2021)
    Introduction: Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy ...
  • Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
    Alfano, Rossella; Plusquin, Michelle; Robinson, Oliver; Brescianini, Sonia; Chatzi, Leda; Keski-Rahkonen, Pekka; Handakas, Evangelos; Maitre, Léa; Nawrot, Tim S.; Robinot, Nivonirina; Roumeliotaki, Theano; Sassi, Franco; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Zugna, Daniela (Nature Research, 2022)
    Background: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight ...
  • Determinants of the urinary and serum metabolome in children from six European populations
    Lau, Chung-Ho E.; Maitre, Léa; Urquiza, José M.; Casas Sanahuja, Maribel; Vrijheid, Martine; Coen, Muireann (BioMed Central, 2018)
    Background: Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate ...
  • Diet as a source of exposure to environmental contaminants for pregnant women and children from six european countries
    Papadopoulou, Eleni, 1985-; Haug, Line Småstuen; Sakhi, Amrit Kaur; Andrušaitytė, Sandra; Basagaña Flores, Xavier; Brantsaeter, Anne Lise; Casas Sanahuja, Maribel; Fernández-Barrés, Sílvia; Gražulevičienė, Regina; Knutsen, Helle Katrine; Maitre, Léa; Meltzer, Helle Margrete; McEachan, Rosemary R.C.; Roumeliotaki, Theano; Slama, Rémy; Vafeiadi, Marina, 1983-; Wright, John; Vrijheid, Martine; Thomsen, Cathrine; Chatzi, Leda (National Institute of Environmental Health Sciences, 2019)
    Background: Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. Objectives: Our objective was to ...
  • Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries
    Julvez, Jordi; López Vicente, Mònica, 1988-; Warembourg, Charline; Maitre, Léa; Philippat, Claire; Gützkow, Kristine B.; Guxens Junyent, Mònica; Evandt, Jorunn; Andrušaitytė, Sandra; Burgaleta Díaz, Miguel, 1981-; Casas Sanahuja, Maribel; Chatzi, Leda; de Castro, Montserrat; Donaire González, David; Gražulevičienė, Regina; Hernandez-Ferrer, Carles, 1987-; Heude, Barbara; McEachan, Rosie; Mon-Williams, Mark; Nieuwenhuijsen, Mark J.; Robinson, Oliver; Sakhi, Amrit Kaur; Sebastián Gallés, Núria; Slama, Rémy; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Thomsen, Cathrine; Urquiza, José M.; Vafeiadi, Marina, 1983-; Basagaña Flores, Xavier; Vrijheid, Martine (Elsevier, 2021)
    Epidemiological studies mostly focus on single environmental exposures. This study aims to systematically assess associations between a wide range of prenatal and childhood environmental exposures and cognition. The study ...
  • Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study
    Maitre, Léa; Júlvez Calvo, Jordi; López Vicente, Mònica, 1988-; Warembourg, Charline; Tamayo-Uria, Ibon; Guxens Junyent, Mònica; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; de Castro, Montserrat; Gonzalez, Juan Ramon; Hernandez-Ferrer, Carles, 1987-; Marquez, Sandra; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Vrijheid, Martine (Elsevier, 2021)
    Background: Environmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad ...
  • Early-life environmental exposures and childhood obesity: an exposome-wide approach
    Vrijheid, Martine; Fossati, Serena; Maitre, Léa; Márquez, Sandra; Casas Sanahuja, Maribel; de Castro, Montserrat; Donaire González, David; Robinson, Oliver; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; Valentín, Antònia; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Basagaña Flores, Xavier; Chatzi, Leda (National Institute of Environmental Health Sciences, 2020)
    Background: Chemical and nonchemical environmental exposures are increasingly suspected to influence the development of obesity, especially during early life, but studies mostly consider single exposure groups. Objectives: ...
  • Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort
    Agier, Lydiane; Basagaña Flores, Xavier; Maitre, Léa; Casas Sanahuja, Maribel; de Castro, Montserrat; Donaire González, David; Nieuwenhuijsen, Mark J.; Robinson, Oliver; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; Valentín, Antònia; Vrijheid, Martine; Siroux, Valérie (Elsevier, 2019)
    Background: Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range ...
  • Green CURIOCITY: a study protocol for a European birth cohort study analysing childhood heat-related health impacts and protective effects of urban natural environments
    van den Bosch, Matilda A.; Basagaña Flores, Xavier; Mudu, Pierpaolo; Kendrovski, Vladimir; Maitre, Léa; Hjertager Krog, Norun; Marit Aasvang, Gunn; Gražulevičienė, Regina; McEachan, Rosemary R.C.; Vrijheid, Martine; Nieuwenhuijsen, Mark J. (BMJ Publishing Group, 2022)
    Introduction: The European climate is getting warmer and the impact on childhood health and development is insufficiently understood. Equally, how heat-related health risks can be reduced through nature-based solutions, ...
  • Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
    Maitre, Léa; De Bont, Jeroen, 1989-; Casas Sanahuja, Maribel; Robinson, Oliver; Basagaña Flores, Xavier; Borràs, Eva; Bustamante Pineda, Mariona; de Castro, Montserrat; Donaire González, David; Estivill, Xavier, 1955-; Fossati, Serena; González, Juan Ramón; Hernández-Ferrer, Carles; Júlvez Calvo, Jordi; Manzano Salgado, Cyntia Beatriz, 1987-; Sabidó Aguadé, Eduard, 1981-; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; van Gent, Diana; Vives Usano, Marta, 1990-; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Vrijheid, Martine (BMJ Publishing Group, 2018)
    PURPOSE: Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and ...
  • In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children
    Vives Usano, Marta, 1990-; Hernández-Ferrer, Carles; Maitre, Léa; Ruiz Arenas, Carlos, 1990-; Borràs, Eva; Casas Sanahuja, Maribel; Estivill, Xavier, 1955-; González, Juan Ramón; Sabidó Aguadé, Eduard, 1981-; Vrijheid, Martine; Bustamante Pineda, Mariona (BioMed Central, 2020)
    Background: The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only ...
  • In-utero and childhood chemical exposome in six European mother-child cohorts
    Haug, Line Småstuen; Casas Sanahuja, Maribel; Maitre, Léa; Basagaña Flores, Xavier; De Bont, Jeroen, 1989-; González, Juan Ramón; Sunyer Deu, Jordi; Urquiza, José M.; Vrijheid, Martine; Thomsen, Cathrine (Elsevier, 2018)
    Background: Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. Objectives: To characterize concentrations of a large ...
  • Influence of the urban exposome on birth weight
    Nieuwenhuijsen, Mark J.; Basagaña Flores, Xavier; Urquiza, José M.; Maitre, Léa; de Castro, Montserrat; Valentín, Antònia; Donaire González, David; Dadvand, Payam; Vrijheid, Martine; Slama, Rémy (National Institute of Environmental Health Sciences, 2019)
    Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating ...