Browsing by Author "Macias, Sara"

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  • DGCR8 HITS-CLIP reveals novel functions for the Microprocessor
    Macias, Sara; Plass Pórtulas, Mireya, 1982-; Stajuda, Agata; Michlewski, Gracjan; Eyras Jiménez, Eduardo; Cáceres, Javier F. (Nature Research, 2012)
    The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. Using high-throughput sequencing and cross-linking ...
  • Drosha regulates gene expression independently of RNA cleavage function
    Gromak, Natalia; Dienstbier, Martin; Macias, Sara; Plass Pórtulas, Mireya, 1982-; Eyras Jiménez, Eduardo; Cáceres, Javier F.; Proudfoot, Nicholas J. (Elsevier, 2013)
    Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we demonstrate that, in addition to miRNA sequences, Drosha specifically ...
  • The Microprocessor controls the activity of mammalian retrotransposons
    Heras, Sara R.; Macias, Sara; Plass Pórtulas, Mireya, 1982-; Fernandez, Noemí; Cano Ferrer, David; Eyras Jiménez, Eduardo; Garcia Perez, José L.; Cáceres, Javier F. (Nature Research, 2013)
    More than half of the human genome is made of transposable elements whose ongoing mobilization is a driving force in genetic diversity; however, little is known about how the host regulates their activity. Here, we show ...