Browsing by Author "Lucas, Gavin, 1977-"

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  • Analysis of gene-gene interactions among common variants in candidate cardiovascular genes in coronary artery disease
    Musameh, Muntaser D.; Wang, William Y. S.; Nelson, Christopher P.; Lluís Ganella, Carla, 1984-; Debiec, Radoslaw; Subirana Cachinero, Isaac; Elosua Llanos, Roberto; Balmforth, Anthony J.; Ball, Stephen G.; Hall, Alistair S.; Kathiresan, Sekar; Thompson, John R.; Lucas, Gavin, 1977-; Samani, Nilesh J.; Tomaszewski, Maciej (Public Library of Science, 2015)
    OBJECTIVE: Only a small fraction of coronary artery disease (CAD) heritability has been explained by common variants identified to date. Interactions between genes of importance to cardiovascular regulation may account for ...
  • Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater Than the Parts? A Genetic Approach
    Elosua Llanos, Roberto; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin, 1977-; Sayols, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí Clapés, Mariano; Siscovick, David; Mellander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat de la Iglesia, Jaume (Lippincott Williams & Wilkins, 2016)
    BACKGROUND: Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk ...
  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
    Pattaro, Cristian; Friedrich, Nele; Elosua Llanos, Roberto; Lucas, Gavin, 1977- (Nature Publishing Group, 2016)
    Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ...
  • Genetic factors associated with coronary heart disease and analysis of their predictive capacity
    Lluís Ganella, Carla, 1984- (Universitat Pompeu Fabra, 2012-10-03)
    The main expansion of the discovery of genetic variants associated with complex diseases has occurred during the last decade. This expansion has been accompanied, and in some sense motivated, by the desire to use this ...
  • Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction
    Lucas, Gavin, 1977-; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Musameh, Muntaser D.; González Ruiz, Juan Ramón; Nelson, Christopher P.; Sentí Clapés, Mariano; Myocardial Infarction Genetics; Wellcome Trust Case Control Constortium; Schwartz, Stephen M; Siscovick, David; O'Donnell, Christopher J; Melander, Olle; Salomaa, Veikko; Purcell, Shaun; Altshuler, David; Samani, Nilesh J.; Kathiresan, Sekar; Elosua Llanos, Roberto (Public Library of Science (PLoS), 2012)
    The genetic loci that have been found by genome-wide association studies to modulate risk of coronary heart disease explain only a fraction of its total variance, and gene-gene interactions have been proposed as a potential ...
  • Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density
    Alonso, Nerea; Garcia Giralt, Natàlia; Lucas, Gavin, 1977-; Elosua Llanos, Roberto; Ralston, Stuart H. (BMJ Publishing Group, 2018)
    OBJECTIVES: To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis. METHODS: Here we conduct a genome-wide association study in 1553 postmenopausal ...

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