Browsing by Author "Loza, María I."

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  • A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry
    March-Vila, Eric; Ferretti, Giacomo; Terricabras, Emma; Ardao, Inés; Brea, José Manuel; Varela, María José; Arana, Álvaro; Rubiolo, Juan Andrés; Sanz, Ferran; Loza, María I.; Sánchez, Laura; Alonso, Héctor; Pastor Maeso, Manuel (Springer, 2023)
    There is a widely recognized need to reduce human activity's impact on the environment. Many industries of the leather and textile sector (LTI), being aware of producing a significant amount of residues (Keßler et al. 2021; ...
  • Development of fluorescent probes that target serotonin 5-HT2B receptors
    Azuaje, Jhonny; López, Paula; Iglesias, Alba; de la Fuente, Rocío Ailim; Pérez Rubio, José M.; García, Diego; Maciej Stępniewski, Tomasz; García Mera, Xerardo; Brea, José; Selent, Jana; Pérez Sala, Dolores; Castro, Marián; Loza, María I.; Sotelo, Eddy (Nature Publishing Group, 2017)
    Some 5-HT2B fluorescent probes were obtained by tagging 1-(2,5-dimethoxy-4-iodophenyl)-propan-2-amine (DOI) with a subset of fluorescent amines. Some of the resulting fluorescent ligands showed excellent affinity and ...
  • G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits
    Kossatz de Mello, Elk, 1977-; Diez Alarcia, Rebeca; Gaitonde, Supriya A.; Ramon Duaso, Carla, 1987-; Stepniewski, Tomasz Maciej, 1988-; Aranda García, David; Muneta Arrate, Itziar; Tepaz, Elodie; Saen-Oon, Suwipa; Soliva, Robert; Shahraki, Aida; Moreira, David; Brea, José; Loza, María I.; Torre Fornell, Rafael de la; Kolb, Peter; Bouvier, Michel; Meana, J. Javier; Robledo, Patricia, 1958-; Selent, Jana (Nature Research, 2024)
    G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive ...
  • Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization
    Iglesias, Alba; Cimadevila, Marta; de la Fuente, Rocío Ailim; Martí Solano, Maria; Cadavid, María Isabel; Castro, Marián; Selent, Jana; Loza, María I.; Brea, José (Elsevier, 2017)
    The serotonin 2A (5-HT2A) receptor is a G-protein coupled receptor (GPCR) with a conserved disulfide bridge formed by Cys148 (transmembrane helix 3, TM3) and Cys227 (extracellular loop 2, ECL-2). We hypothesized that ...
  • Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands
    López Muñoz, Laura; Sanz, Ferran; Pastor Maeso, Manuel; Selent, Jana; Loza, María I.; Brea, José; Areias, Filipe; Ortega, Raquel; Masaguer, Christian F.; Raviña, Enrique (Elsevier, 2009)
    A series of new benzolactam derivatives was synthesized and the derivatives were evaluated for their/naffinities at the dopamine D1, D2, and D3 receptors. Some of these compounds showed high D2 and/or/nD3 affinity and ...
  • Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivative as pontential antipsychotics
    López Muñoz, Laura; Aranda, Reyes; Villalba, Karen; Raviña, Enrique; Masaguer, Christian F.; Brea, José; Areias, Filipe; Domínguez, Eduardo; Selent, Jana; Sanz, Ferran; Loza, María I.; Pastor Maeso, Manuel (American Chemical Society (ACS), 2008)
    The complex etiology of schizophrenia has prompted researchers to develop clozapine-related multitarget/nstrategies to combat its symptoms. Here we describe a series of new 6-aminomethylbenzofuranones in an/neffort to find ...

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