Browsing by Author "Lloreta Trull, Josep, 1958-"

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  • A 12-gene expression signature is associated with aggressive histological in prostate cancer: SEC14L1 and TCEB1 genes are potential markers of progression. American journal of pathology
    Agell, Laia; Hernández, Silvia; Nonell Mazelón, Lara; Lorenzo Perez, Marta; Puigdecanet Riubugent, Eulàlia; Muga, Silvia de; Juanpere, Nuria; Bermudo, Raquel; Fernández, Pedro Luís; Lorente Garin, José Antonio; Serrano Figueras, Sergi; Lloreta Trull, Josep, 1958- (Elsevier, 2012)
    The main challenge for clinical management of prostate cancer is to distinguish tumors that will progress faster and will show a higher tendency to recur from the more indolent ones. We have compared expression profiles ...
  • A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Rothman, Nathaniel; Real, Francisco X.; Serra, Consol; Lloreta Trull, Josep, 1958-; Chanock, Stephen J. (Nature Research, 2010)
    We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a ...
  • ARID1A alterations are associated with FGFR3-wild type, poor-prognosis, urothelial bladder tumors
    Balbás Martínez, Cristina; Rodríguez Pinilla, María; Casanova, Ariel; Domínguez, Orlando; Pisano, David G.; Gómez López, Gonzalo; Lloreta Trull, Josep, 1958-; Lorente Garin, José Antonio; Malats i Riera, Núria; Real, Francisco X. (Public Library of Science (PLoS), 2013)
    Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological, genetic, and epigenetic levels. Exome sequencing has identified ARID1A as a novel tumor suppressor gene coding for a chromatin remodeling ...
  • Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal
    del Rey, Javier; Prat, Esther; Ponsa, Immaculada; Lloreta Trull, Josep, 1958-; Gelabert, Antoni; Algaba, Ferran; Camps-Puchadas, Jordi; Miró, Rosa (BioMed Central, 2010)
    Background: Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder ...
  • Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility
    Núñez Ollé, Marc, 1984-; Jung, Carole; Terré, Berta; Balsiger, Norman A.; Plata, Cristina; Roset i Huguet, Ramon; Pardo Pastor, Carlos; Garrido, Marta; Rojas, Santiago; Alameda Quitllet, Francisco; Lloreta Trull, Josep, 1958-; Martín Caballero, Juan; Flores, Juana M.; Stracker, Travis; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964-; Gil Gómez, Gabriel (Impact Journals, 2017)
    Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple ...
  • Contribution of Human papillomavirus in neuroendocrine tumors from a series of 10,575 invasive cervical cancer cases
    Alejo, María; Alemany, Laia; Clavero, Omar; Quirós, Beatriz; Vighi, Susana Graciela; Seoud, Muhieddine; Cheng-Yang, Chou; Garland, Suzanne Marie; Juanpere, Nuria; Lloreta Trull, Josep, 1958-; Tous, Sara; Klaustermeier, Jo Ellen; Quint, Wim; Bosch José, Francesc Xavier, 1947-; Sanjosé Llongueras, Silvia de; Lloveras Rubio, Belen; RIS Human papillomavirus (HPV) TT study group (Elsevier, 2018)
    AIMS: Neuroendocrine tumors (NET) of the cervix are rare tumors with a very aggressive course. The human papillomavirus (HPV) has been linked to its etiology. The objective of this study is to describe HPV prevalence and ...
  • Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis
    Czachorowski, Maciej J; Amaral, André F.S.; Montes-Moreno, Santiago; Lloreta Trull, Josep, 1958-; Carrato, Alfredo; Tardón, Adonina; Morente, Manuel M; Kogevinas, Manolis; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2012)
    Aberrant overexpression of cyclooxygenase-2 (COX2) is observed in urothelial carcinoma of the bladder (UCB). Studies evaluating COX2 as a prognostic marker in UCB report contradictory results. We determined the prognostic ...
  • Diesel exhaust and bladder cancer risk by pathologic stage and grade subtypes
    Koutros, Stella; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Silverman, Debra T. (Elsevier, 2020)
    Background: The International Agency for Research on Cancer (IARC) classifies diesel engine exhaust as carcinogenic to humans based on sufficient evidence for lung cancer. IARC noted, however, an increased risk of bladder ...
  • Diffuse dermal mucinosis secondary to colony-stimulating factor 1 receptor monoclonal antibody treatment: A novel and peculiar drug-induced diffuse cutaneous mucinosis
    Olmos Alpiste, Ferran; Segura Tigell, Sonia; Tomás-Velázquez, Alejandra; Aguado, Leyre; España, Agustín; Arriola Aperribay, Edurne; Martín-Algarra, Salvador; Barranco Sanz, Luis Carlos; Lloreta Trull, Josep, 1958-; Pujol Vallverdú, Ramon Maria (Wiley, 2021)
    Colony-stimulating factor 1 receptor (CSF1R) inhibitors represent a new class of immune-modulatory drugs, mostly investigated in clinical trials in different malignant neoplasms. Four patients, diagnosed with recurrent or ...
  • Effect of insulin on ACE2 activity and kidney function in the non-obese diabetic mouse (PLoS ONE (2014))
    Riera Oliva, Marta; Márquez, Eva; Clotet, Sergi; Gimeno Beltran, Javier; Roca-Ho, Heleia; Lloreta Trull, Josep, 1958-; Juanpere, Nuria; Batlle, Daniel; Pascual Santos, Julio; Soler, María José (Public Library of Science (PLoS), 2014)
    We studied the non-obese diabetic (NOD) mice model because it develops autoimmune diabetes that resembles human type 1 diabetes. In diabetic mice, urinary albumin excretion (UAE) was ten-fold increased at an “early stage” ...
  • ERG overexpression plus SLC45A3 (prostein) and PTEN expression loss: Strong association of the triple hit phenotype with an aggressive pathway of prostate cancer progression
    Hernández Llodrà, Sílvia; Juanpere, Nuria; Muga, Silvia de; Lorenzo Perez, Marta; Gil Ortega, Joan; Font Tello, Alba 1990-; Agell, Laia; Albero-González, Raquel; Segalés, Laura; Merino, José; Serrano, Laia; Fumadó Ciutat, Lluis; Cecchini Rosell, Lluís; Lloreta Trull, Josep, 1958- (Impact Journals, 2017)
    TMPRSS2 and SLC45A3 rearrangements may coexist in the same tumor. ERG rearrangements and PTEN loss are concomitant events in prostate cancer (PrCa), and can cooperate in progression. We have reported that mRNA expression ...
  • FOXO1 down-regulation is associated with worse outcome in bladder cancer and adds significant prognostic information to p53 overexpression
    Lloreta Trull, Josep, 1958-; Font-Tello, Alba; Juanpere, Nuria; Frances, Albert; Lorenzo Perez, Marta; Nonell Mazelón, Lara; Muga, Silvia de; Vázquez‐de las Heras, Ivonne; Cecchini Rosell, Lluís; Hernández, Silvia (Elsevier, 2017)
    Nuclear FOXOs mediate cell cycle arrest and promote apoptosis. FOXOs and p53 could have similar effects as tumor suppressor genes. In spite of extensive literature, little is known about the role of FOXO1 and its relationship ...
  • Genetic variation in the TP53 pathway and bladder cancer risk: a comprehensive analysis
    Pineda, Silvia; Milne, Roger L.; Calle, M. Luz; Rothman, Nathaniel; López De Maturana, Evangelina; Herranz, Jesús; Kogevinas, Manolis; Chanock, Stephen J.; Tardón, Adonina; Márquez, Mirari; Guey, Lin T.; García Closas, Montserrat; Lloreta Trull, Josep, 1958-; Baum, Erin; González Neira, Anna; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Silverman, Debra T.; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in other ...
  • Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background
    Menashe, Idan; Real, Francisco X.; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Rothman, Nathaniel (Public Library of Science (PLoS), 2012)
    Pathway analysis of genome-wide association studies (GWAS) offer a unique opportunity to collectively evaluate genetic variants with effects that are too small to be detected individually. We applied a pathway analysis to ...
  • mTOR intersects antibody-inducing signals from TACI in marginal zone B cells
    Sintes, Jordi; Serrano Figueras, Sergi; Lloreta Trull, Josep, 1958-; Cerutti, Andrea, 1965- (Nature Publishing Group, 2017)
    Mechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic reconfiguration of marginal zone (MZ) B cells, a pre-activated lymphocyte ...
  • Murine ES-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation
    Rovira Clusellas, Meritxell; Delaspre, Fabien; Massumi, Mohammad; Serra Pascual, Selma A., 1981-; Valverde, M. A. (Miguel Ángel), 1963-; Lloreta Trull, Josep, 1958-; Dufresne, Marlène; Payré, Bruno; Konieczny, Stephen F.; Savatier, Pierre; Real, Francisco X.; Skoudy, Anouchka (Elsevier, 2008)
    Background & Aims: Acinar cells constitute 90% of the pancreas epithelium, are polarized, and secrete digestive enzymes. These cells play a crucial role in pancreatitis and pancreatic cancer. However, there are limited ...
  • Muscle regeneration potential and satellite cell activation profile during recovery following hindlimb immobilization in mice
    Guitart, Maria; Lloreta Trull, Josep, 1958-; Mañas García, Laura, 1991-; Barreiro Portela, Esther (Wiley, 2018)
    Reduced muscle activity leads to muscle atrophy and function loss in patients and animal models. Satellite cells (SCs) are postnatal muscle stem cells that play a pivotal role in skeletal muscle regeneration following ...
  • NAT2 slow acetylation and GSTM1 null genotypes increase bladder cancer risk: results from the Spanish Bladder Cancer Study and meta-analyses
    García Closas, Montserrat; Malats i Riera, Núria; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Castaño Vinyals, Gemma; Torà, Montserrat; Fernández-Avilés, Francisco; Real, Francisco X.; Rothman, Nathaniel (Elsevier, 2005)
    BACKGROUND: Many reported associations between common genetic polymorphisms and complex diseases have not been confirmed in subsequent studies. An exception could be the association between NAT2 slow acetylation, GSTM1 ...
  • NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    García Closas, Montserrat; Malats i Riera, Núria; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Real, Francisco X.; Rothman, Nathaniel (Elsevier, 2005)
    Background: Many reported associations between common genetic polymorphisms and complex diseases have not been confirmed in subsequent studies. An exception could be the association between NAT2 slow acetylation, GSTM1 ...
  • Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models.
    López De Maturana, Evangelina; Picornell, Antoni; Masson-Lecomte, Alexandra; Kogevinas, Manolis; Márquez, Mirari; Carrato, Alfredo; Tardón, Adonina; Lloreta Trull, Josep, 1958-; García Closas, Montserrat; Silverman, Debra T.; Rothman, Nathaniel; Chanock, Stephen J.; Real, Francisco X.; Goddard, M. E.; Malats i Riera, Núria; SBC/EPICURO Study Investigators (BioMed Central, 2016)
    BACKGROUND: We adapted Bayesian statistical learning strategies to the prognosis field to investigate if genome-wide common SNP improve the prediction ability of clinico-pathological prognosticators and applied it to ...