Browsing by Author "Llorca, Javier"

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  • Adequacy of early-stage breast cancer systemic adjuvant treatment to Saint Gallen-2013 statement: the MCC-Spain study
    Gómez-Acebo, Inés; Sala, Maria; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (Nature Research, 2021)
    The St Gallen Conference endorsed in 2013 a series of recommendations on early breast cancer treatment. The main purpose of this article is to ascertain the clinical factors associated with St Gallen-2013 recommendations ...
  • Adherence to nutrition-based cancer prevention guidelines and breast, prostate and colorectal cancer risk in the MCC-Spain case-control study
    Romaguera Bosch, Dora; Gracia Lavedan, Esther; Molinuevo, Amaia; De Batlle, Jordi; Mendez, Michelle A.; Moreno, Víctor; Vidal, Carmen; Castelló, Adela; Pérez-Gómez, Beatriz; Martín Sánchez, Vicente; Molina, Antonio J.; Dávila-Batista, Verónica; Dierssen Sotos, Trinidad; Gómez-Acebo, Inés; Llorca, Javier; Guevara, Marcela; Castilla, Jesús; Urtiaga, Carmen; Llorens-Ivorra, Cristóbal; Fernández-Tardón, Guillermo; Tardón, Adonina; Lorca Marín, José Andrés; Marcos-Gragera, Rafael; Huerta, José María; Olmedo-Requena, Rocío; Jiménez-Moleón, José Juan; Altzibar, Jone Miren; de Sanjosé, Silvia; Pollan, Marina; Aragonés, Núria; Castaño Vinyals, Gemma; Kogevinas, Manolis; Amiano, Pilar (Wiley, 2017)
    Prostate, breast and colorectal cancer are the most common tumours in Spain. The aim of the present study was to evaluate the association between adherence to nutrition-based guidelines for cancer prevention and prostate, ...
  • Breast cancer risk and night shift work in a case-control study in a Spanish population
    Papantoniou, Kyriaki, 1983-; Castaño Vinyals, Gemma; Espinosa Díaz, Ana; Aragonés, Núria; Pérez-Gómez, Beatriz; Ardanaz Aicua, Eva; Altzibar, Jone Miren; Martín Sánchez, Vicente; Gómez-Acebo, Inés; Llorca, Javier; Muñoz, David; Tardón, Adonina; Peiró, Rosana; Marcos-Gragera, Rafael; Pollan, Marina; Kogevinas, Manolis (Springer, 2016)
    Epidemiologic and animal data indicate that night shift work might increase the risk for breast cancer. We evaluated the association of night work with different clinical types of breast cancer in a population based ...
  • Changes in Individual and Contextual Socio-Economic Level Influence on Reproductive Behavior in Spanish Women in the MCC-Spain Study
    Gómez-Acebo, Inés; Castaño Vinyals, Gemma; Sala Serra, Maria; Kogevinas, Manolis; Llorca, Javier (BioMed Central, 2020)
    Background: The association between socioeconomic level and reproductive factors has been widely studied. For example, it is well known that women with lower socioeconomic status (SES) tend to have more children, the age ...
  • Circulating miRNAs signature on breast cancer: the MCC-Spain project
    Gómez-Acebo, Inés; Llorca, Javier; Alonso-Molero, Jéssica; Díaz-Martínez, Marta; Pérez-Gómez, Beatriz; Amiano, Pilar; Belmonte, Thalía; Molina, Antonio J.; Burgui, Rosana; Castaño Vinyals, Gemma; Moreno, Víctor; Molina-Barceló, Ana; Marcos-Gragera, Rafael; Kogevinas, Manolis; Pollán, Marina; Dierssen Sotos, Trinidad (BioMed Central, 2023)
    Purpose: To build models combining circulating microRNAs (miRNAs) able to identify women with breast cancer as well as different types of breast cancer, when comparing with controls without breast cancer. Method: miRNAs ...
  • Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results
    Alonso-Molero, Jéssica; Molina, Antonio J.; Jiménez-Moleón, José Juan; Pérez-Gómez, Beatriz; Martín, Vicente; Moreno, Víctor; Amiano, Pilar; Ardanaz Aicua, Eva; Sanjosé Llongueras, Silvia de; Salcedo-Bellido, Inmaculada; Fernández-Tardón, Guillermo; Alguacil Ojeda, Juan; Salas, Dolores; Marcos-Gragera, Rafael; Chirlaque, María Dolores; Aragonés, Núria; Castaño Vinyals, Gemma; Pollan, Marina; Kogevinas, Manolis; Llorca, Javier (BMJ Publishing Group, 2019)
    Purpose: Since 2016, the multicase-control study in Spain (MCC-Spain) has focused towards the identification of factors associated with cancer prognosis. Inception cohorts of patients with colorectal, breast and prostate ...
  • Dietary constituents: relationship with breast cancer prognostic (MCC-SPAIN Follow-Up)
    Dierssen Sotos, Trinidad; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (MDPI, 2020)
    The aim of this study was to characterize the relationship between the intake of the major nutrients and prognosis in breast cancer. A cohort based on 1350 women with invasive (stage I-IV) breast cancer (BC) was followed ...
  • Dietary zinc and risk of prostate cancer in Spain: MCC-Spain Study
    Gutiérrez-González, Enrique; Castelló, Adela; Fernández-Navarro, Pablo; Castaño Vinyals, Gemma; Llorca, Javier; Salas-Trejo, Dolores; Salcedo-Bellido, Inmaculada; Aragonés, Núria; Fernández-Tardón, Guillermo; Alguacil Ojeda, Juan; Gracia Lavedan, Esther; García-Esquinas, Esther; Gómez-Acebo, Inés; Amiano, Pilar; Romaguera Bosch, Dora; Kogevinas, Manolis; Pollan, Marina; Pérez-Gómez, Beatriz (MDPI, 2018)
    Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. ...
  • Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study
    Gómez-Acebo, Inés; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (BioMed Central, 2018)
    BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include ...
  • Lifetime exposure to brominated trihalomethanes in drinking water and swimming pool attendance are associated with chronic lymphocytic leukemia: a Multicase-Control Study in Spain (MCC-Spain)
    Donat-Vargas, Carolina; Kogevinas, Manolis; Benavente, Yolanda; Costas, Laura; Campo, Elias; Castaño Vinyals, Gemma; Fernandez-Tardon, Guillermo; Llorca, Javier; Gómez-Acebo, Inés; Aragonés, Núria; Pollan, Marina; Casabonne, Delphine; Villanueva Belmonte, Cristina (Nature Research, 2023)
    Background: Chronic lymphocytic leukemia (CLL) etiology is poorly understood, and carcinogenic chemicals in drinking and recreational water are candidates. Objective: To evaluate the association between drinking-water ...
  • Long-term exposure to nitrate and trihalomethanes in drinking water and prostate cancer: a multicase–control study in Spain (MCC-Spain)
    Donat-Vargas, Carolina; Kogevinas, Manolis; Castaño Vinyals, Gemma; Pérez-Gómez, Beatriz; Llorca, Javier; Vanaclocha-Espi, Mercedes; Fernandez-Tardon, Guillermo; Costas, Laura; Aragonés, Núria; Gómez-Acebo, Inés; Moreno, Víctor; Pollan, Marina; Villanueva, Cristina M. (National Institute of Environmental Health Sciences, 2023)
    Nitrate and trihalomethanes (THMs) in drinking water are widespread and are potential human carcinogens. We evaluated the association between drinking-water exposure to nitrate and THMs and prostate cancer. During the ...
  • Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
    Gómez-Acebo, Inés; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (Public Library of Science (PLoS), 2018)
    INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be ...
  • Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design
    Castano-Vinyals, Gemma; Aragonés, Núria; Pérez-Gómez, Beatriz; Martín, Vicente; Llorca, Javier; Moreno, Víctor; Altzibar, Jone Miren; Ardanaz, Eva; Sanjosé Llongueras, Silvia de; Jiménez-Moleón, José Juan; Tardón, Adonina; Alguacil, Juan; Peiró, Rosana; Marcos-Gragera, Rafael; Navarro, Carmen; Pollán, Marina; Kogevinas, Manolis; MCC-Spain Study Group (Elsevier, 2015)
    Introduction. We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods. Between 2008-2013, 10,183 ...
  • Prostate cancer genetic propensity risk score may modify the association between this tumour and type 2 diabetes mellitus (MCC-Spain study)
    Barrios-Rodríguez, Rocío; García-Esquinas, Esther; Pérez-Gómez, Beatriz; Castaño Vinyals, Gemma; Llorca, Javier; Fernández de Larrea-Baz, Nerea; Olmedo-Requena, Rocío; Vanaclocha-Espi, Mercedes; Alguacil Ojeda, Juan; Fernández-Tardón, Guillermo; Fernández-Navarro, Pablo; Cecchini Rosell, Lluís; Lope, Virginia; Gómez-Acebo, Inés; Aragonés, Núria; Kogevinas, Manolis; Pollan, Marina; Jiménez-Moleón, José Juan (Nature Research, 2022)
    Background: Some studies have reported an inverse association between type 2 diabetes mellitus (T2DM) and prostate cancer (PCa), but results on this issue are still inconsistent. In this study, we evaluate whether this ...
  • Quality of life in a cohort of 1078 women diagnosed with breast cancer in spain: 7-year follow-up results in the MCC-Spain Study
    Alonso Molero, Jessica; Castaño Vinyals, Gemma; Castells, Xavier; Kogevinas, Manolis; Llorca, Javier (MDPI, 2020)
    Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this ...
  • Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study
    Dierssen Sotos, Trinidad; Andreu García, Montserrat; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (Elsevier, 2017)
    The potential protective effect of renin-angiotensin system (RAS) inhibitors is a subject of increasing interest due to their possible role as chemopreventive agents against colorectal cancer (CRC). To evaluate this ...
  • Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project
    Dierssen Sotos, Trinidad; Palazuelos, Camilo; Jiménez-Moleón, José Juan; Aragonés, Núria; Altzibar, Jone Miren; Castaño Vinyals, Gemma; Martín Sánchez, Vicente; Gómez-Acebo, Inés; Guevara, Marcela; Tardón, Adonina; Pérez-Gómez, Beatriz; Amiano, Pilar; Moreno, Víctor; Molina, Antonio J.; Alonso Molero, Jessica; Moreno-Iribas, Conchi; Kogevinas, Manolis; Pollan, Marina; Llorca, Javier (BioMed Central, 2018)
    BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred ...
  • Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case-Control (MCC) Study
    Gómez-Acebo, Inés; Dierssen Sotos, Trinidad; Fernández-Navarro, Pablo; Palazuelos, Camilo; Moreno, Víctor; Aragonés, Núria; Castaño Vinyals, Gemma; Jiménez-Moleón, José Juan; Ruiz-Cerdá, Jose Luis; Pérez-Gómez, Beatriz; Ruiz Dominguez, José Manuel; Alonso Molero, Jessica; Pollan, Marina; Kogevinas, Manolis; Llorca, Javier (Nature Publishing Group, 2017)
    Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors ...
  • The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study.
    Gómez-Acebo, Inés; Tusquets Trias de Bes, Ignacio; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (Public Library of Science (PLoS) , 2016)
    INTRODUCTION: The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled ...
  • Total effective xenoestrogen burden in serum samples and risk for breast cancer in a population-based multicase-control study in Spain.
    Pastor-Barriuso, Roberto; Fernandez, Mariana F.; Castaño Vinyals, Gemma; Whelan, Denis ; Pérez-Gómez, Beatriz; Llorca, Javier; Villanueva Belmonte, Cristina; Guevara, Marcela; Molina-Molina, Jose Manuel; Artacho-Cordón, Francisco; Barriuso-Lapresa, Laura; Tusquets Trias de Bes, Ignacio; Dierssen Sotos, Trinidad; Aragonés, Núria; Olea, Nicolás; Kogevinas, Manolis; Pollan, Marina (National Institute of Environmental Health Sciences, 2016)
    BACKGROUND: Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings. OBJECTIVES: We assessed the combined estrogenic effects of mixtures of ...

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