Visualitza per autoria "Lee, Sung Sik"

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  • Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade
    Sharifian, Hoda; Lampert, Fabienne; Stojanovski, Klement; Regot Rodríguez de Mier, Sergi; Vaga, Stefania; Buser, Raymond; Lee, Sung Sik; Koeppl, Heinz; Posas Garriga, Francesc; Pelet, Serge; Peter, Matthias (Royal Society of Chemistry, 2015)
    Tight regulation of the MAP kinase Hog1 is crucial for survival under changing osmotic conditions. Interestingly, we found that Hog1 phosphorylates multiple upstream components, implying feedback regulation within the ...
  • Positive feedback induces switch between distributive and processive phosphorylation of Hog1
    Mosbacher, Maximilian; Lee, Sung Sik; Yaakov, Gilad; Nadal Ribelles, Mariona, 1984-; Nadal Clanchet, Eulàlia de; van Drogen, Frank; Posas Garriga, Francesc; Peter, Matthias; Claassen, Manfred (Nature Research, 2023)
    Cellular decision making often builds on ultrasensitive MAPK pathways. The phosphorylation mechanism of MAP kinase has so far been described as either distributive or processive, with distributive mechanisms generating ...

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