Browsing by Author "Lao Grueso, Oscar, 1976-"

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  • A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
    López De Maturana, Evangelina; Rodríguez, Juan Antonio; Lao Grueso, Oscar, 1976-; Iglesias Coma, Mar; Cecchini Rosell, Lluís; Ilzarbe Sánchez, Lucas; Real, Francisco X.; Malats i Riera, Núria (BioMed Central, 2021)
    Background: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% ...
  • Adaptive evolution of loci covarying with the human African Pygmy phenotype
    Mendizábal Eceizabarrena, Isabel, 1981-; Marigorta, Urko M.; Lao Grueso, Oscar, 1976-; Comas, David, 1969- (Springer, 2012)
    African Pygmies are hunter-gatherer populations from the equatorial rainforest that present the lowest height averages among humans. The biological basis and the putative adaptive role of the short stature of Pygmy populations ...
  • Analysis of the batch effect Due to sequencing center in population statistics quantifying rare events in the 1000 Genomes Project
    Maceda Porto, Iago, 1986-; Lao Grueso, Oscar, 1976- (MDPI, 2021)
    The 1000 Genomes Project (1000G) is one of the most popular whole genome sequencing datasets used in different genomics fields and has boosting our knowledge in medical and population genomics, among other fields. Recent ...
  • Approximate Bayesian computation with deep learning supports a third archaic introgression in Asia and Oceania
    Mondal, Mayukh, 1989-; Bertranpetit, Jaume, 1952-; Lao Grueso, Oscar, 1976- (Nature Research, 2019)
    Since anatomically modern humans dispersed Out of Africa, the evolutionary history of Eurasian populations has been marked by introgressions from presently extinct hominins. Some of these introgressions have been identified ...
  • Assessing the digenic model in rare disorders using population sequencing data
    Moreno-Ruiz, Nerea; Genomics England Research Consortium; Lao Grueso, Oscar, 1976-; Aróstegui Gorospe, Juan Ignacio; Laayouni, Hafid, 1968-; Casals López, Ferran (Nature Research, 2022)
    An important fraction of patients with rare disorders remains with no clear genetic diagnostic, even after whole-exome or whole-genome sequencing, posing a difficulty in giving adequate treatment and genetic counseling. ...
  • Chimpanzee genomic diversity reveals ancient admixture with bonobos
    de Manuel, Marc; Kuhlwilm, Martin; Sousa, Victor C.; Prado Martínez, Javier, 1987-; Hernández Rodríguez, Jéssica, 1983-; Dupanloup, Isabelle; Lao Grueso, Oscar, 1976-; Heredia Genestar, José María, 1985-; Kuderna, Lukas, 1989-; Casals López, Ferran; Angedakin, Samuel; Arandjelovic, Mimi; Boesch, Christophe; Kühl, Hjalmar S.; Vigilant, Linda; Navarro i Cuartiellas, Arcadi, 1969-; Excoffier, Laurent; Marquès i Bonet, Tomàs, 1975- (American Association for the Advancement of Science (AAAS), 2016)
    Our closest living relatives, chimpanzees and bonobos, have a complex demographic history. We analyzed the high-coverage whole genomes of 75 wild-born chimpanzees and bonobos from 10 countries in Africa. We found that ...
  • Estimating heritability of song considering within-individual variance in a wild songbird: The collared flycatcher
    Jablonszky, Mónika; Canal, David; Hegyi, Gergely; Herényi, Márton; Laczi, Miklós; Lao Grueso, Oscar, 1976-; Markó, Gábor; Nagy, Gergely; Rosivall, Balázs; Szász, Eszter; Török, János; Zsebők, Sándor; Garamszegi, László Zsolt (Frontiers, 2022)
    Heritable genetic variation is a prerequisite for adaptive evolution; however, our knowledge about the heritability of plastic traits, such as behaviors, is scarce, especially in wild populations. In this study, we ...
  • Evolutionary and medical consequences of archaic introgression into modern human genomes
    Dolgova, Olga; Lao Grueso, Oscar, 1976- (MDPI, 2018)
    The demographic history of anatomically modern humans (AMH) involves multiple migration events, population extinctions and genetic adaptations. As genome-wide data from complete genome sequencing becomes increasingly ...
  • Exploring the contribution to ADHD of genes involved in Mendelian disorders presenting with hyperactivity and/or inattention
    Fernàndez-Castillo, Noèlia; Cabana-Domínguez, Judit; Kappel, Djenifer B.; Torrico, Bàrbara; Weber, Keike; Lesch, Klaus-Peter; Lao Grueso, Oscar, 1976-; Reif, Andreas; Cormand, Bru (MDPI, 2021)
    Attention-deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder characterized by hyperactivity, impulsivity, and/or inattention, which are symptoms also observed in many rare genetic disorders. We ...
  • Fine-scale population structure in five rural populations from the Spanish Eastern Pyrenees using high-coverage whole-genome sequence data
    Maceda Porto, Iago, 1986-; Martín Álvarez, Miguel; Athanasiadis, Georgios; Tonda, Raúl; Camps-Puchadas, Jordi; Beltran, Sergi; Camps, Agustí; Fàbrega, Jordi; Felisart, Josefina; Grané, Joan; Remón, José Luis; Serra, Jordi; Moral, Pedro; Lao Grueso, Oscar, 1976- (Springer Nature, 2021)
    The area of the Spanish Pyrenees is particularly interesting for studying the demographic dynamics of European rural areas given its orography, the main traditional rural condition of its population and the reported higher ...
  • Genomic analysis of the natural history of attention-deficit/hyperactivity disorder using Neanderthal and ancient Homo sapiens samples
    Esteller Cucala, Paula; Maceda Porto, Iago, 1986-; Børglum, Anders D.; Demontis, Ditte; Faraone, Stephen V.; Cormand, Bru; Lao Grueso, Oscar, 1976- (Nature Research, 2020)
    Attention-deficit/hyperactivity disorder (ADHD) is an impairing neurodevelopmental condition highly prevalent in current populations. Several hypotheses have been proposed to explain this paradox, mainly in the context of ...
  • Geographic stratification of linkage disequilibrium: a worldwide population study in a region of chromosome 22
    González Neira, Anna; Calafell i Majó, Francesc; Navarro i Cuartiellas, Arcadi, 1969-; Lao Grueso, Oscar, 1976-; Cann, Howard M.; Comas, David, 1969-; Bertranpetit, Jaume, 1952- (BioMed Central, 2004)
    Recent studies of haplotype diversity in a number of genomic regions have suggested that long stretches of DNA are preserved in the same chromosome, with little evidence of recombination events. The knowledge of the extent ...
  • Medicine in the light of evolution
    Dolgova, Olga; Lao Grueso, Oscar, 1976- (MDPI, 2018)
    Evolutionary medicine applies the principles of evolutionary biology to understand why we get sick rather than how, and it has undergone an exponential growth since the early 1990s [...].
  • Modelling the demographic history of human North African genomes points to a recent soft split divergence between populations
    Serradell Noguera, Jose Miguel; Lorenzo Salazar, Jose M.; Flores, Carlos; Lao Grueso, Oscar, 1976-; Comas, David, 1969- (BioMed Central, 2024)
    Background: North African human populations present a complex demographic scenario due to the presence of an autochthonous genetic component and population substructure, plus extensive gene flow from the Middle East, Europe, ...
  • Recent human evolution has shaped geographical differences in susceptibility to disease
    Marigorta, Urko M.; Lao Grueso, Oscar, 1976-; Casals López, Ferran; Calafell i Majó, Francesc; Morcillo Suárez, Carlos, 1969-; Faria, Rui; Bosch Fusté, Elena; Serra, François; Bertranpetit, Jaume, 1952-; Dopazo, Hernán; Navarro i Cuartiellas, Arcadi, 1969- (BioMed Central, 2011)
    Background: Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a ...
  • Statistical analysis of post mortem DNA damage-derived miscoding lesions in Neandertal mitochondrial DNA.
    Vives, Sergi; Gilbert, M Thomas; Arenas, Conxita; Gigli, Elena, 1978-; Lao Grueso, Oscar, 1976-; Lalueza Fox, Carles, 1965- (BioMed Central, 2008)
    Background: We have analysed the distribution of post mortem DNA damage derived miscoding lesions from the datasets of seven published Neandertal specimens that have extensive cloned sequence coverage over the mitochondrial ...
  • The Dutch Y-chromosomal landscape
    Altena, Eveline; Smeding, Risha; van der Gaag, Kristiaan J.; Larmuseau, Maarten H. D.; Decorte, Ronny; Lao Grueso, Oscar, 1976-; Kayser, Manfred; Kraaijenbrink, Thirsa; de Knijff, Peter (Nature Research, 2020)
    Previous studies indicated existing, albeit limited, genetic-geographic population substructure in the Dutch population based on genome-wide data and a lack of this for mitochondrial SNP based data. Despite the aforementioned ...
  • The genomic history of the Aegean palatial civilizations
    Clemente, Florian; Dolgova, Olga; Lao Grueso, Oscar, 1976-; Papageorgopoulou, Christina (Elsevier, 2021)
    The Cycladic, the Minoan, and the Helladic (Mycenaean) cultures define the Bronze Age (BA) of Greece. Urbanism, complex social structures, craft and agricultural specialization, and the earliest forms of writing characterize ...
  • The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
    Fibla, Joan; Maceda Porto, Iago, 1986-; Laplana, Marina; Guerrero, Montserrat; Martín Álvarez, Miguel; Burgueño, Jesús; Camps, Agustí; Fàbrega, Jordi; Felisart, Josefina; Grané, Joan; Remón, José Luis; Serra, Jordi; Moral, Pedro; Lao Grueso, Oscar, 1976- (Frontiers, 2023)
    The genetic variation of the European population at a macro-geographic scale follows genetic gradients which reflect main migration events. However, less is known about factors affecting mating patterns at a micro-geographic ...
  • Whole-genome sequence analysis of a Pan African set of samples reveals archaic gene flow from an extinct basal population of modern humans into sub-Saharan populations
    Lorente-Galdós, Belén, 1981-; Lao Grueso, Oscar, 1976-; Serra Vidal, Gerard, 1989-; Santpere Baró, Gabriel, 1981-; Kuderna, Lukas, 1989-; Arauna, Lara R; Fadhlaoui-Zid, Karima; Pimenoff, Ville N.; Soodyall, Himla; Zalloua, Pierre A.; Marquès i Bonet, Tomàs, 1975-; Comas, David, 1969- (BioMed Central, 2019)
    Background: Population demography and gene flow among African groups, as well as the putative archaic introgression of ancient hominins, have been poorly explored at the genome level. Results: Here, we examine 15 African ...

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