Browsing by Author "Langohr, Klaus"

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  • 3D reconstruction does not improve agreement and results in an increase in surgical indications in proximal humeral fractures
    Torrens Cánovas, Carlos; Marí, Raquel; Cuenca, Marta; Ferrer, Tulia; Langohr, Klaus; Santana Pérez, Fernando (Elsevier, 2018)
    The objective of this study is to analyze the effect of different imaging modalities in treatment decision making in proximal humeral fractures. After evaluation of 116 consecutive proximal humeral fractures, observers ...
  • A lower olfactory capacity is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body Mass index in women.
    Pastor, Antonio; Fernández Aranda, Fernando; Fitó Colomer, Montserrat; Jiménez Murcia, Susana; Botella, Cristina; Fernández Real, Jose M.; Frühbeck, Gema; Tinahones Madueño, Francisco José; Fagundo, Ana B.; Rodríguez Rodríguez, Juan Francisco; Agüera, Zaida; Langohr, Klaus; Casanueva, Felipe F.; Torre Fornell, Rafael de la (Public Library of Science , 2016)
    The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in ...
  • A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
    Sola Llopis, Susana de; Torre Fornell, Rafael de la; Sánchez Benavides, Gonzalo; Benejam, Bessy; Cuenca Royo, Aida Ma, 1981-; Del Hoyo Soriano, Laura; Rodríguez, Joan; Catuara Solarz, Silvina, 1986-; Sánchez Gutiérrez, Judit; Dueñas-Espín, Iván, 1979-; Hernández, Gimena; Peña-Casanova, J. (Jordi); Langohr, Klaus; Videla, Sebastià; Blehaut, Henry; Farré Albaladejo, Magí; Dierssen, Mara; TESDAD Study Group (Frontiers, 2015)
    The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological ...
  • BDNF and cortisol in the diagnosis of cocaine-induced depression
    Fonseca Casals, Francina, 1972-; Mestre-Pintó, Juan Ignacio; Rodríguez-Minguela, Rocío; Papaseit Fontanet, Esther; Pérez Mañá, Clara; Langohr, Klaus; Barbuti, Margherita; Farré Albaladejo, Magí; Torrens, Marta; Neurodep Group (Frontiers, 2022)
    Background: Major depressive disorder (MDD) and cocaine use disorder (CUD) are related with disability and high mortality rates. The assessment and treatment of psychiatric comorbidity is challenging due to its high ...
  • Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans: a randomized, controlled trial
    Boronat Rigol, Anna, 1990-; Mateus Rodriguez, Julian Andrés; Soldevila-Domenech, Natalia; Guerra, Mercè; Rodríguez-Morató, Jose, 1987-; Varon, Carlota; Muñoz Aguayo, Daniel; Barbosa, Francina; Morales, Juan Carlos; Gaedigk, Andreas; Langohr, Klaus; Covas Planells, Maria Isabel; Pérez Mañá, Clara; Fitó Colomer, Montserrat; Tyndale, Rachel F.; Torre Fornell, Rafael de la (Elsevier, 2019)
    Introduction: The simple phenol hydroxytyrosol (OHTyr) has been associated with the beneficial health effects of extra virgin olive oil. Pre-clinical studies have identified Tyr hydroxylation, mediated by cytochrome P450 ...
  • Clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"): the influence of gender and genetics (CYP2D6, COMT, 5-HTT)
    Pardo Lozano, Ricardo; Farré Albaladejo, Magí; Yubero Lahoz, Samanta, 1985-; O'Mathuna, Brian; Torrens, Marta; Mustata, Cristina; Pérez Mañá, Clara; Langohr, Klaus; Cuyàs, Elisabet; Carbó Banús, Marcel·lí; Torre Fornell, Rafael de la (Public Library of Science (PLoS), 2012)
    The synthetic psychostimulant MDMA (±3,4-methylenedioxymethamphetamine, ecstasy) acts as an indirect serotonin, dopamine, and norepinephrine agonist and as a mechanism-based inhibitor of the cytochrome P-450 2D6 (CYP2D6). ...
  • Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome
    Catuara Solarz, Silvina, 1986-; Espinosa-Carrasco, José; Erb, Ionas; Langohr, Klaus; Gonzalez, Juan Ramon; Notredame, Cedric; Dierssen, Mara (Society for Neuroscience, 2016)
    Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, ...
  • Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice
    Martin Casals, Miquel; Gutiérrez Martos, Miriam, 1989-; Cabrera Ortega, Roberto; Langohr, Klaus; Maldonado, Rafael, 1961-; Farré Albaladejo, Magí; Torre Fornell, Rafael de la (Springer, 2021)
    Rationale: Cocaine addiction is a chronic relapsing disorder that lacks of an effective treatment. Isoflavones are a family of compounds present in different plants and vegetables like soybeans that share a common chemical ...
  • Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans
    Boronat Rigol, Anna, 1990-; Mateus Rodriguez, Julian Andrés; Soldevila-Domenech, Natalia; Guerra Albà, Mercè; Rodríguez-Morató, Jose, 1987-; Varon, Carlota; Muñoz, Daniel; Barbosa, Francina; Morales, Juan Carlos; Gaedigk, Andreas; Langohr, Klaus; Covas Planells, Maria Isabel; Pérez Mañá, Clara; Fitó Colomer, Montserrat; Tyndale, Rachel F.; Torre Fornell, Rafael de la (Elsevier, 2019)
    Here we present new and original data on the endogenous conversion of tyrosol (Tyr) into hydroxytyrosol (OHTyr) in humans and its effects on the cardiovascular system. A randomized, crossover, controlled clinical trial was ...
  • Effects of mixing energy drinks with alcohol on driving-related skills
    Pérez Mañá, Clara; Mateus Rodriguez, Julian Andrés; Díaz-Pellicer, Patricia; Díaz-Baggerman, Ariadna; Pérez, Marta; Pujadas Bastardes, Mitona; Fonseca Casals, Francina, 1972-; Papaseit Fontanet, Esther; Pujol, Jesús; Langohr, Klaus; Torre Fornell, Rafael de la (Oxford University Press, 2022)
    Background: Energy drinks (EDs) reduce sleepiness and fatigue and improve driving performance whereas alcohol does just the opposite. Although it is a trendy combination among young people, the effects of alcohol mixed ...
  • Evaluation of metabolic changes in acute intermittent porphyria patients by targeted metabolomics
    Gomez-Gomez, Àlex; Aguilera, Paula; Langohr, Klaus; Casals, Gregori; Pavon, Cristina; Marcos del Águila, Josep, 1971-; To-Figueras, Jordi; Pozo Mendoza, Óscar J., 1975- (MDPI, 2022)
    Acute intermittent porphyria (AIP) is an inherited rare hepatic disorder due to mutations within the hydroxymethylbilane gene. AIP patients with active disease overproduce aminolevulinic acid (ALA) and porphobilinogen (PBG) ...
  • Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression.
    Udina, M. ; Navinés, Ricard; Egmond, E.  ; Oriolo, Giovanni; Langohr, Klaus; Gimenez, Dolors; Valdés, M. ; Gómez-Gil, E. ; Grande, Iria; Gratacós Mayora, Mònica; Kapczinski, F.  ; Artigas, Francesc; Vieta, Eduard; Solà, Rosa; Martín Santos, Rocío (Oxford University Press, 2016)
    BACKGROUND: The role of inflammation in mood disorders has received increased attention. There is substantial evidence that cytokine therapies, such as interferon alpha (IFN-alpha), can induce depressive symptoms. Indeed, ...
  • The influence of genetic and environmental factors among MDMA users in cognitive performance
    Cuyàs, Elisabet; Verdejo García, Antonio; Fagundo, Ana B.; Khymenets, Olha, 1974-; Rodríguez, Joan; Cuenca Royo, Aida Ma, 1981-; De Sola Llopis, Susana; Langohr, Klaus; Peña-Casanova, J. (Jordi); Torrens, Marta; Martín Santos, Rocío; Farré Albaladejo, Magí; Torre Fornell, Rafael de la (Public Library of Science (PLoS), 2011)
    This study is aimed to clarify the association between MDMA cumulative use and cognitive dysfunction, and the potential role of candidate genetic polymorphisms in explaining individual differences in the cognitive effects ...
  • N-of-1 clinical trials in nutritional interventions directed at improving cognitive function
    Soldevila-Domenech, Natalia; Boronat Rigol, Anna, 1990-; Langohr, Klaus; Torre Fornell, Rafael de la (Frontiers, 2019)
    Longer life expectancy has led to an increase in the prevalence of age-related cognitive decline and dementia worldwide. Due to the current lack of effective treatment for these conditions, preventive strategies represent ...
  • Non-linear formation of EtG and FAEEs after controlled administration of low to moderate doses of ethanol
    Pérez Mañá, Clara; Farré Albaladejo, Magí; Pastor, Antonio; Fonseca Casals, Francina, 1972-; Torrens, Marta; Menoyo Colomer, Esther; Pujadas Bastardes, Mitona; Frias, Silvia; Langohr, Klaus; Torre Fornell, Rafael de la (Oxford University Press, 2017)
    AIMS: Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The ...
  • Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism
    Goday Arno, Alberto; Farré Albaladejo, Magí; Rodríguez-Morató, Jose, 1987-; Ramón Moros, José Manuel; Pérez Mañá, Clara; Papaseit Fontanet, Esther; Civit, Ester; Langohr, Klaus; Carbó Banús, Marcel·lí; Benaiges Foix, David; Castañer, Olga; Flores-Le-Roux, Juana Antonia; Pera Roman, Manuel Ramón; Grande Posa, Luís; Torre Fornell, Rafael de la (Springer, 2017)
    PURPOSE: The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver ...
  • Principal component analysis of the effects of environmental enrichment and (-)-epigallocatechin-3-gallate on age-associated learning deficits in a mouse model of down syndrome.
    Catuara Solarz, Silvina, 1986-; Espinosa-Carrasco, José; Erb, Ionas; Langohr, Klaus; Notredame, Cedric; González Ruiz, Juan Ramón; Dierssen, Mara (Frontiers, 2015)
    Down syndrome (DS) individuals present increased risk for Alzheimer's disease (AD) neuropathology and AD-type dementia. Here, we investigated the use of green tea extracts containing (-)-epigallocatechin-3-gallate (EGCG), ...
  • Role of PARP activity in lung cancer-induced cachexia: Effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype
    Chacón Cabrera, Alba, 1988-; Mateu-Jimenez, Mercè; Langohr, Klaus; Fermoselle Pérez, Clara, 1985-; García-Arumí, Elena; Andreu, Antoni; Yélamos López, José; Barreiro Portela, Esther (Wiley, 2017)
    Strategies to treat cachexia are still at its infancy. Enhanced muscle protein breakdown and ubiquitin-proteasome system are common features of cachexia associated with chronic conditions including lung cancer (LC). ...
  • Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study)
    Cieuta-Walti, Cécile; Cuenca Royo, Aida Ma, 1981-; Langohr, Klaus; López-Vílchez, María Ángeles; García García, Jordi; Aldea-Perona, Ana; Forcano, Laura; Gomis González, Maria, 1988-; Torre Fornell, Rafael de la; PERSEUS Study Group (Elsevier, 2022)
    Purpose: although some caregivers are using epigallocatechin gallate (EGCG) off label in hopes of improving cognition in young adults with Down syndrome (DS), nothing is known about its safety, tolerability, and efficacy ...
  • Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults.
    Del Hoyo Soriano, Laura; Xicota Vila, Laura, 1987-; Sánchez Benavides, Gonzalo; Cuenca Royo, Aida Ma, 1981-; Sola Llopis, Susana de; Langohr, Klaus; Fagundo, Ana B.; Farré Albaladejo, Magí; Dierssen, Mara; Torre Fornell, Rafael de la (Frontiers, 2015)
    Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains; nearly all adults show neuropathology of Alzheimer's disease (AD), including ...