Browsing by Author "Lanfumey, Laurence"

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  • 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence
    Martin, Cedric B.P.; Martin, Vincent S.; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    BACKGROUND: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence
    Martin, Cedric B.P.; Martín, Vicente; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence
    Martin, Cedric B.P.; Martin, Vincent S.; Trigo i Rodríguez, Josep M.; Chevarin, Caroline; Maldonado, Rafael, 1961-; Fink, Latham H.; Cunningham, Kathryn A.; Hamon, Michel; Lanfumey, Laurence; Mongeau, Raymond (Oxford University Press, 2015)
    Background: Desensitization and blockade of 5-HT2C receptors (5-HT2CR) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is ...
  • Cerebral oxidative metabolism mapping in four genetic mouse models of anxiety and mood disorders
    Matrov, Denis; Kaart, Tanel; Lanfumey, Laurence; Maldonado, Rafael, 1961-; Sharp, Trevor; Tordera, Rosa M.; Kelly, Paul A.; Deakin, Bill; Harro, Jaanus (Elsevier, 2019)
    The psychopathology of depression is highly complex and the outcome of studies on animal models is divergent. In order to find brain regions that could be metabolically distinctively active across a variety of mouse ...
  • Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors.
    Viñals Álvarez, Xavier, 1985-; Moreno, Estefanía; Lanfumey, Laurence; Cordomí, Arnau; Pastor, Antonio; Torre Fornell, Rafael de la; Gasperini, Paola; Navarro, Gemma; Howell, Lesley A.; Pardo, Leonardo; Lluís, Carmen; Canela, Enric I.; McCormick, Peter J.; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Public Library of Science, 2015)
    Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of ...
  • Involvement of 5-HT2A receptors in MDMA reinforcement and cue-induced reinstatement of MDMA-seeking behaviour
    Orejarena Serrano, María-Juliana, 1980-; Lanfumey, Laurence; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Cambridge University Press, 2011)
    The serotonergic system appears crucial for (±)-3,4-methylenedioxymethamphetamine (MDMA) reinforcing properties. Current evidence indicates that serotonin 5-HT2A receptors (5-HT2ARs) modulate mesolimbic dopamine (DA) ...
  • Lack of CB1 receptor activity impairs serotonergic negative feedback
    Aso Pérez, Ester; Renoir, Thibault; Valverde Granados, Olga; Lanfumey, Laurence; Maldonado, Rafael, 1961-; Hamon, Michel; Ledent, Catherine; Mengod, Guadalupe (Wiley-Blackwell, 2009)
    Serotonergic and endocannabinoid systems are important substrates for the control of emotional behavior and growing evidence show an involvement in the pathophysiology of mood disorders. In the present study, the absence ...