Browsing by Author "López-Botet, Miguel"

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  • Muccio, Letizia; Bertaina, Alice; Falco, Michela; Pende, Daniela; Meazza, Raffaella; López-Botet, Miguel; Moretta, Lorenzo; Locatelli, Franco; Moretta, Alessandro; Della Chiesa, Mariella (Haematologica, 2016)
    We analyzed the impact of human cytomegalovirus infection on the development of natural killer cells in 27 pediatric patients affected by hematological malignancies, who had received a HLA-haploidentical hematopoietic stem ...
  • Solana, Rafael; Tarazona, Raquel; Aiello, Allison E; Akbar, Arne N; Appay, Victor; Beswick, Mark; Bosch, Jos A; Campos, Carmen; Cantisán, Sara; Cicin Sain, Luca; Derhovanessian, Evelyna; Ferrando Martínez, Sara; Frasca, Daniela; Fulöp, Tamas; Govind, Sheila; Grubeck Loebenstein, Beatrix; Hill, Ann; Hurme, Mikko; Kern, Florian; Larbi, Anis; López-Botet, Miguel; Maier, Andrea B; McElhaney, Janet E; Moss, Paul; Naumova, Elissaveta; Nikolich Zugich, Janko; Pera, Alejandra; Rector, Jerrarld L; Riddell, Natalie; Sanchez Correa, Beatriz; Sansoni, Paolo; Sauce, Delphine; Lier, Rene van; Wang, George C; Wills, Mark R; Zielinski, Maciej; Pawelec, Graham (BioMed Central, 2012)
    Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in ...
  • López-Botet, Miguel; Muntasell i Castellví, Aura, 1972-; Martínez-Rodriguez, José E.; López-Montañés, María; Costa-García, Marcel; Pupuleku, Aldi, 1985- (Elsevier, 2016)
    Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. ...
  • López-Botet, Miguel; Vilches, Carlos; Redondo Pachón, María Dolores; Muntasell i Castellví, Aura, 1972-; Pupuleku, Aldi, 1985-; Yelamos López, Jose; Pascual Santos, Julio; Crespo Barrio, Marta (Frontiers, 2017)
    Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the ...
  • Pupuleku, Aldi, 1985-; Costa-García, Marcel; Farré, Domènec; Hengel, Hartmut; Angulo Aguado, Ana; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel (Frontiers, 2017)
    Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NK cell receptor, together with ...
  • Costa García, Marcel, 1989-; Ataya, Michelle; Moraru, Manuela; Vilches, Carlos; López-Botet, Miguel; Muntasell i Castellví, Aura, 1972- (Frontiers, 2019)
    Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity. Infection by human cytomegalovirus (HCMV) promotes a ...
  • Holst Hansen, Thomas; Abad Adan, Elena; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel; Jensen, Mogens; Trusina, Ala; García Ojalvo, Jordi (Elsevier, 2017)
    Allele number, or zygosity, is a clear determinant of gene expression in diploid cells. However, the relationship between the number of copies of a gene and its expression can be hard to anticipate, especially when the ...
  • Muntasell i Castellví, Aura, 1972-; Cabo, Mariona; Servitja Tormo, Sonia; Tusquets Trias de Bes, Ignacio; Martínez-García, Maria; Rovira Guerín, Ana; Rojo, Federico; Albanell Mestres, Joan; López-Botet, Miguel (Frontiers, 2017)
    Overexpression of the human epidermal growth factor receptor 2 (HER2) defines a subgroup of breast tumors with aggressive behavior. The addition of HER2-targeted antibodies (i.e., trastuzumab, pertuzumab) to chemotherapy ...
  • Cisneros, Elisa; Moraru, Manuela; Gómez-Lozano, Natalia; López-Botet, Miguel; Vilches, Carlos (Frontiers, 2012)
    A recently developed anti-KIR2DL5 (CD158f) antibody has demonstrated KIR2DL5 expression on the surface of NK and T lymphocytes, making it the last functional KIR identified in the human genome. KIR2DL5 belongs to an ancestral ...
  • Alari-Pahissa, Elisenda; Moreira Villanueva, Antía; Zabalza, Ana; Alvarez-Lafuente, Roberto; Munteis Olivas, Elvira; Vera, Andrea; Arroyo, Rafael; Álvarez Cermeño, Jose Carlos; Villar, Luisa Maria; López-Botet, Miguel; Martínez-Rodriguez, José E. (Wiley, 2018)
    BACKGROUND AND PURPOSE: Cytomegalovirus (CMV) infection has recently been associated with a lower multiple sclerosis (MS) susceptibility, although it remains controversial whether it has a protective role or is merely an ...
  • Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel (American Association for Cancer Research, 2016)
    The report by Curti et al. highlightsthe potential of NK cell-based adoptive cellular immunotherapy in oncology,currently boosted by advances in the knowledge on NK cell biology and in their ex-vivo GMP manipulation.Several ...
  • Llinás, Laura; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Raïch-Regué, Dàlia; Mir, Marisa; Yélamos López, José; López-Botet, Miguel; Pascual Santos, Julio; Crespo Barrio, Marta (Nature Research, 2019)
    Several studies have assessed clinical outcomes after steroid withdrawal (SW) in kidney transplant (KT) recipients, but little is known about its potential impact on lymphocyte subpopulations. We designed a prospective ...
  • Muntasell i Castellví, Aura, 1972-; Costa-García, Marcel; Vera, Andrea; Marina-García, Noemí; Kirschning, Carsten J.; López-Botet, Miguel (Frontiers, 2013)
    Natural killer (NK) cells play an important role in the defense against viral infections. Activation of resting NK cells is tightly controlled by the balance of surface inhibitory and activating receptors and aided by ...