Browsing by Author "López-Botet, Miguel"

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  • Moreira Villanueva, Antía; Alari-Pahissa, Elisenda; Munteis Olivas, Elvira; Vera, Andrea; Zabalza, Ana; Llop, Mireia; Villarrubia, Noelia; Costa García, Marcel, 1989-; Álvarez-Lafuente, Roberto; Villar, Luisa Maria; López-Botet, Miguel; Martínez-Rodriguez, José E. (Frontiers, 2019)
    Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK cells bearing the CD94/NKG2C receptor with a characteristic phenotypic ...
  • Pascual Guàrdia, Sergi, 1979-; Ataya, Michelle; Ramírez Martínez, Isabel; Yélamos López, José; Chalela Rengifo, Roberto José, 1985-; Bellido, Salomé; López-Botet, Miguel; Gea Guiral, Joaquim (BioMed Central, 2020)
    Abstract: Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habit, ...
  • Muccio, Letizia; Bertaina, Alice; Falco, Michela; Pende, Daniela; Meazza, Raffaella; López-Botet, Miguel; Moretta, Lorenzo; Locatelli, Franco; Moretta, Alessandro; Della Chiesa, Mariella (Haematologica, 2016)
    We analyzed the impact of human cytomegalovirus infection on the development of natural killer cells in 27 pediatric patients affected by hematological malignancies, who had received a HLA-haploidentical hematopoietic stem ...
  • Solana, Rafael; Tarazona, Raquel; Aiello, Allison E.; Akbar, Arne N.; Appay, Victor; Beswick, Mark; Bosch, Jos A.; Campos, Carmen; Cantisán, Sara; Cicin Sain, Luca; Derhovanessian, Evelyna; Ferrando Martínez, Sara; Frasca, Daniela; Fulöp, Tamas; Govind, Sheila; Grubeck Loebenstein, Beatrix; Hill, Ann; Hurme, Mikko; Kern, Florian; Larbi, Anis; López-Botet, Miguel; Maier, Andrea B.; McElhaney, Janet E.; Moss, Paul; Naumova, Elissaveta; Nikolich Zugich, Janko; Pera, Alejandra; Rector, Jerrarld L.; Riddell, Natalie; Sanchez Correa, Beatriz; Sansoni, Paolo; Sauce, Delphine; Lier, Rene van; Wang, George C.; Wills, Mark R.; Zielinski, Maciej; Pawelec, Graham (BioMed Central, 2012)
    Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in ...
  • Asenjo, Judit; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel; Moraru, Manuela; Vilches, Carlos (Wiley, 2021)
  • López-Botet, Miguel; Muntasell i Castellví, Aura, 1972-; Martínez-Rodriguez, José E.; López-Montañés, María; Costa-García, Marcel; Pupuleku, Aldi, 1985- (Elsevier, 2016)
    Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. ...
  • López-Botet, Miguel; Vilches, Carlos; Redondo Pachón, María Dolores; Muntasell i Castellví, Aura, 1972-; Pupuleku, Aldi, 1985-; Yélamos López, José; Pascual Santos, Julio; Crespo Barrio, Marta (Frontiers, 2017)
    Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the ...
  • Pupuleku, Aldi, 1985-; Costa-García, Marcel; Farré, Domènec; Hengel, Hartmut; Angulo Aguado, Ana; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel (Frontiers, 2017)
    Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NK cell receptor, together with ...
  • Cisneros, Elisa; Moraru, Manuela; Gómez-Lozano, Natalia; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel; Vilches, Carlos (Frontiers, 2020)
    Inhibitory Killer-cell Immunoglobulin-like Receptors (KIR) specific for HLA class I molecules enable human natural killer cells to monitor altered antigen presentation in pathogen-infected and tumor cells. KIR genes display ...
  • Costa García, Marcel, 1989-; Ataya, Michelle; Moraru, Manuela; Vilches, Carlos; López-Botet, Miguel; Muntasell i Castellví, Aura, 1972- (Frontiers, 2019)
    Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity. Infection by human cytomegalovirus (HCMV) promotes a ...
  • Zabalza, Ana; Vera, Andrea; Alari-Pahissa, Elisenda; Munteis Olivas, Elvira; Moreira Villanueva, Antía; Yélamos López, José; Llop, Mireia; López-Botet, Miguel; Martínez Rodríguez, Jose E. (BioMed Central, 2020)
    Background: Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in ...
  • Holst Hansen, Thomas; Abad Adan, Elena; Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel; Jensen, Mogens; Trusina, Ala; García Ojalvo, Jordi (Elsevier, 2017)
    Allele number, or zygosity, is a clear determinant of gene expression in diploid cells. However, the relationship between the number of copies of a gene and its expression can be hard to anticipate, especially when the ...
  • Muntasell i Castellví, Aura, 1972-; Cabo, Mariona, 1991-; Servitja Tormo, Sonia; Tusquets Trias de Bes, Ignacio; Martínez-García, Maria; Rovira Guerín, Ana; Rojo, Federico; Albanell Mestres, Joan; López-Botet, Miguel (Frontiers, 2017)
    Overexpression of the human epidermal growth factor receptor 2 (HER2) defines a subgroup of breast tumors with aggressive behavior. The addition of HER2-targeted antibodies (i.e., trastuzumab, pertuzumab) to chemotherapy ...
  • Cisneros, Elisa; Moraru, Manuela; Gómez-Lozano, Natalia; López-Botet, Miguel; Vilches, Carlos (Frontiers, 2012)
    A recently developed anti-KIR2DL5 (CD158f) antibody has demonstrated KIR2DL5 expression on the surface of NK and T lymphocytes, making it the last functional KIR identified in the human genome. KIR2DL5 belongs to an ancestral ...
  • Llinàs-Mallol, Laura; Redondo Pachón, María Dolores; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Yélamos López, José; Duran Jordà, Xavier, 1974-; Faura, Anna; López-Botet, Miguel; Pascual Santos, Julio; Crespo Barrio, Marta (MDPI, 2020)
    Classical immunosuppression based on steroids, calcineurin inhibitors, and mycophenolate results in several unwanted effects and unsatisfactory long-term outcomes in kidney transplantation (KT). New immunosuppressors search ...
  • Alari-Pahissa, Elisenda; Moreira Villanueva, Antía; Zabalza, Ana; Alvarez-Lafuente, Roberto; Munteis Olivas, Elvira; Vera, Andrea; Arroyo, Rafael; Álvarez Cermeño, Jose Carlos; Villar, Luisa Maria; López-Botet, Miguel; Martínez-Rodriguez, José E. (Wiley, 2018)
    BACKGROUND AND PURPOSE: Cytomegalovirus (CMV) infection has recently been associated with a lower multiple sclerosis (MS) susceptibility, although it remains controversial whether it has a protective role or is merely an ...
  • Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel (American Association for Cancer Research, 2016)
    The report by Curti et al. highlightsthe potential of NK cell-based adoptive cellular immunotherapy in oncology,currently boosted by advances in the knowledge on NK cell biology and in their ex-vivo GMP manipulation.Several ...
  • Alari-Pahissa, Elisenda; Ataya Fernández, Michelle, 1993-; Moraitis, Ilias; Campos Ruiz, Miriam; Altadill, Mireia; Muntasell i Castellví, Aura, 1972-; Moles, Anna; López-Botet, Miguel (Public Library of Science (PLoS), 2021)
    Epstein Barr virus (EBV) causes a highly prevalent and lifelong infection contributing to the development of some malignancies. In addition to the key role played by T cells in controlling this pathogen, NK cells mediate ...
  • Llinàs-Mallol, Laura; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Raïch-Regué, Dàlia; Mir, Marisa; Yélamos López, José; López-Botet, Miguel; Pascual Santos, Julio; Crespo Barrio, Marta (Nature Research, 2019)
    Several studies have assessed clinical outcomes after steroid withdrawal (SW) in kidney transplant (KT) recipients, but little is known about its potential impact on lymphocyte subpopulations. We designed a prospective ...
  • Ataya, Michelle; Redondo Pachón, María Dolores; Llinàs-Mallol, Laura; Yélamos López, José; Heredia, Gemma; Pérez-Sáez, María José; Vila, Joan; Costa García, Marcel, 1989-; Raïch-Regué, Dàlia; Vilches, Carlos; Pascual, Julio (Pascual Santos); Crespo Barrio, Marta; López-Botet, Miguel (Wiley-Blackwell, 2019)
    Cytomegalovirus (CMV) infection constitutes a complication for kidney transplant recipients (KTR) and CMV-specific T cells reduce the risk of viral replication in seropositive patients. CMV promotes the adaptive differentiation ...