Browsing by Author "López Rodríguez, M. Cristina"

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  • Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors
    Pereira, Vanessa; Millet, Queensta; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina; Gaveriaux-Ruff, Claire; Wood, John N. (F1000Research, 2018)
    Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state. We ...
  • Analysis of NFAT5 expression and activity in response to toll-like receptors
    Lunazzi, Giulia (Universitat Pompeu Fabra, 2019-03-06)
    Stimulation of Toll-like receptors (TLRs) in cells of the innate immune system activates the expression of a proinflammatory and antimicrobial gene program controlled by a network of transcriptional regulators. We show ...
  • Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice
    Morancho Armisen, Beatriz; Minguillón Pedreño, Jordi; Molkentin, Jeffery D.; López Rodríguez, M. Cristina; Aramburu, José (Aramburu Beltrán) (BioMed Central, 2008)
    Background: The transcription factor NFAT5/TonEBP regulates the response of mammalian cells to hypertonicity. However, little is known about the physiopathologic tonicity thresholds that trigger its transcriptional activity ...
  • Analysis of transcription mechanisms that limit type I interferon responses
    Huerga Encabo, Hector (Universitat Pompeu Fabra, 2019-03-01)
    Programa de doctorat en Biomedicina
  • Caracterización funcional de mecanismos que regulan el factor de transcripción NFAT5
    Minguillón Pedreño, Jordi (Universitat Pompeu Fabra, 2012-03-02)
    El NFAT5 es un factor de transcripción de la familia Rel, la cual incluye a los NFATc y los NF-[kappa]B. Hasta ahora, el NFAT5 había sido caracterizado principalmente como un factor de respuesta a estrés osmótico ya que ...
  • Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice
    Ono, Makoto; Izumi, Yuichiro; Maruyama, Kosuke; Yasuoka, Yukiko; Hiramatsu, Akiko; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina; Nonoguchi, Hiroshi; Kakizoe, Yutaka; Adachi, Masataka; Kuwabara, Takashige; Mukoyama, Masashi (American Physiological Society, 2024)
    Nuclear factor of activated T-cells 5 (NFAT5, also called TonEBP/OREBP) is a transcription factor that is activated by hypertonicity and induces osmoprotective genes to protect cells against hypertonic condition. In the ...
  • Circadian regulation of macrophages in homeostasis and disease
    Val Casals, Maria (Universitat Pompeu Fabra, 2020-09-15)
    Els ritmes circadians són oscil·lacions diàries en paràmetres fisiològics necessaris per a què els organismes adaptin la seva activitat als cicles de llum i foscor. A nivell molecular, la maquinària circadiana consisteix ...
  • Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5
    Alberdi Ibarzabal, Maria, 1986-; Iglesias, Marcos; Tejedor Vaquero, Sonia, 1988-; Merino, Ramón; López Rodríguez, M. Cristina; Aramburu, José (Aramburu Beltrán) (Nature Publishing Group, 2017)
    Stress-activated transcription factors influence T-cell function in different physiopathologic contexts. NFAT5, a relative of nuclear factor κB and the calcineurin-activated NFATc transcription factors, protects mammalian ...
  • Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation
    Casella, Valentina, 1991-; Domenjó Vila, Eva, 1993-; Esteve-Codina, Anna; Pedragosa Marín, Mireia, 1988-; Cebollada Rica, Paula; Vidal Barba, Enric; Rubia, Ivan de la; López Rodríguez, M. Cristina; Bocharov, Gennady A.; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Nature Research, 2023)
    Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that contribute to these fates are described, the critical control points and the mechanisms that ...
  • Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5
    Buxadé Fortuny, Maria; Lunazzi, Giulia; Minguillón Pedreño, Jordi; Iborra Mallol, Salvador, 1978-2011; Berga-Bolaños, Rosa; Del Val, Margarita; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2012)
    Toll-like receptors (TLRs) engage networks of transcriptional regulators to induce genes essential for antimicrobial immunity. We report that NFAT5, previously characterized as an osmostress responsive factor, regulates ...
  • Influence of metabolism in the regulation of T cell differentiation
    Tejedor Vaquero, Sonia (Universitat Pompeu Fabra, 2019-01-08)
    Glucose is a key nutrient for T cells. Despite that T cell activation is impaired when they are deprived of glucose, it has also been shown that T effector responses can be elicited in vivo in glucose-poor environments, ...
  • Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5
    Buxadé Fortuny, Maria; Huerga Encabo, Hector, 1989-; Riera-Borrull, Marta; Quintana-Gallardo, Lucía; López-Cotarelo, Pilar; Tellechea Recarte, Mónica, 1989-; Martínez-Martínez, Sara; Redondo, Juan Miguel; Martín Caballero, Juan; Flores, Juana M.; Bosch Fusté, Elena; Rodríguez-Fernández, José Luis; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2018)
    MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses. Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type-specific promoters. ...
  • New insights into transcription that preserve hematopoietic stem cell homeostasis
    Traveset Martínez, Laia (Universitat Pompeu Fabra, 2020-12-09)
    Maintenance of steady-state and stress-adapted hematopoiesis depends on the fitness of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Hematopoietic stem cells (HSCs) can adapt to stress by expanding ...
  • NFAT5 controls the integrity of epidermis
    Muhammad, Khalid; Xavier, Delicia; Klein-Hessling, Stefan; Azeem, Muhammad; Rauschenberger, Tabea; Murti, Krisna; Avots, Andris; Goebeler, Matthias; Klein, Matthias; Bopp, Tobias; Sielaff, Malte; Tenzer, Stefan; Möckel, Sigrid; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina; Kerstan, Andreas; Serfling, Edgar (Frontiers, 2021)
    The skin protects the human body against dehydration and harmful challenges. Keratinocytes (KCs) are the most abundant epidermal cells, and it is anticipated that KC-mediated transport of Na+ ions creates a physiological ...
  • NFAT5 counters long-term IFN-1 responses in hematopoietic stem cells to preserve reconstitution potential
    Traveset Martínez, Laia; Cerdán Porqueras, Víctor; Huerga Encabo, Hector, 1989-; Avalle, Silvia; Esteve-Codina, Anna; Fornas Carreño, Oscar; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (American Society of Hematology, 2024)
    Hematopoietic stem cells (HSCs) readily recover from acute stress, but persistent stress can reduce their viability and long-term potential. Here, we show that the nuclear factor of activated T cells 5 (NFAT5), a transcription ...
  • NFAT5-regulated macrophage polarization supports the proinflammatory function of macrophages and T Lymphocytes
    Tellechea Recarte, Mónica, 1989-; Buxadé Fortuny, Maria; Tejedor Vaquero, Sonia, 1988-; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (American Association of Immunologists - AAI, 2018)
    Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in their microenvironment. This functional plasticity ...
  • Novel transcription mechanisms used by dendritic cells in the tumor immune microenvironment
    Krasko, Anastasia (Universitat Pompeu Fabra, 2024-12-10)
    Interferon is essential for eliciting adaptive immunity against cancer cells. Type I interferon (IFNI) activates proinflammatory responses in dendritic cells (DCs) and this promotes specific anti-tumor T cell responses. ...
  • Novel transcription regulators of tissue macrophages and alternative macrophage polarization
    Higuera González, Laura (2021-10-29)
    Macrophages play crucial roles in the defense of the organism against a wide range of pathogens. Macrophages can rapidly adapt to perturbations in the microenvironment due to the existence of a network of transcription ...
  • Regulation of inflammatory functions of macrophages and T lymphocytes by NFAT5
    Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Frontiers, 2019)
    The transcription factor NFAT5, also known as TonEBP, belongs to the family of Rel homology domain-containing factors, which comprises the NF-κB proteins and the calcineurin-dependent NFAT1 to NFAT4. NFAT5 shares several ...
  • Regulation of T cell fates by the transcription factor NFAT5 in different microenvironments
    Alberdi Ibarzabal, Maria (Universitat Pompeu Fabra, 2018-04-12)
    CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...

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