Browsing by Author "López Rodríguez, M. Cristina"

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  • Pereira, Vanessa; Millet, Queensta; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina; Gaveriaux-Ruff, Claire; Wood, John N. (F1000Research, 2018)
    Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state. We ...
  • Lunazzi, Giulia (Universitat Pompeu Fabra, 2019-03-06)
    Stimulation of Toll-like receptors (TLRs) in cells of the innate immune system activates the expression of a proinflammatory and antimicrobial gene program controlled by a network of transcriptional regulators. We show ...
  • Morancho Armisen, Beatriz; Minguillón Pedreño, Jordi; Molkentin, Jeffery D.; López Rodríguez, M. Cristina; Aramburu, José (Aramburu Beltrán) (BioMed Central, 2008)
    Background: The transcription factor NFAT5/TonEBP regulates the response of mammalian cells to hypertonicity. However, little is known about the physiopathologic tonicity thresholds that trigger its transcriptional activity ...
  • Huerga Encabo, Hector (Universitat Pompeu Fabra, 2019-03-01)
    Programa de doctorat en Biomedicina
  • Minguillón Pedreño, Jordi (Universitat Pompeu Fabra, 2012-03-02)
    El NFAT5 es un factor de transcripción de la familia Rel, la cual incluye a los NFATc y los NF-[kappa]B. Hasta ahora, el NFAT5 había sido caracterizado principalmente como un factor de respuesta a estrés osmótico ya que ...
  • Ono, Makoto; Izumi, Yuichiro; Maruyama, Kosuke; Yasuoka, Yukiko; Hiramatsu, Akiko; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina; Nonoguchi, Hiroshi; Kakizoe, Yutaka; Adachi, Masataka; Kuwabara, Takashige; Mukoyama, Masashi (American Physiological Society, 2024)
    Nuclear factor of activated T-cells 5 (NFAT5, also called TonEBP/OREBP) is a transcription factor that is activated by hypertonicity and induces osmoprotective genes to protect cells against hypertonic condition. In the ...
  • Val Casals, Maria (Universitat Pompeu Fabra, 2020-09-15)
    Els ritmes circadians són oscil·lacions diàries en paràmetres fisiològics necessaris per a què els organismes adaptin la seva activitat als cicles de llum i foscor. A nivell molecular, la maquinària circadiana consisteix ...
  • Alberdi Ibarzabal, Maria, 1986-; Iglesias, Marcos; Tejedor Vaquero, Sonia, 1988-; Merino, Ramón; López Rodríguez, M. Cristina; Aramburu, José (Aramburu Beltrán) (Nature Publishing Group, 2017)
    Stress-activated transcription factors influence T-cell function in different physiopathologic contexts. NFAT5, a relative of nuclear factor κB and the calcineurin-activated NFATc transcription factors, protects mammalian ...
  • Casella, Valentina, 1991-; Domenjó Vila, Eva, 1993-; Esteve-Codina, Anna; Pedragosa Marín, Mireia, 1988-; Cebollada Rica, Paula; Vidal Barba, Enric; Rubia, Ivan de la; López Rodríguez, M. Cristina; Bocharov, Gennady A.; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Nature Research, 2023)
    Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that contribute to these fates are described, the critical control points and the mechanisms that ...
  • Buxadé Fortuny, Maria; Lunazzi, Giulia; Minguillón Pedreño, Jordi; Iborra Mallol, Salvador, 1978-2011; Berga-Bolaños, Rosa; Del Val, Margarita; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2012)
    Toll-like receptors (TLRs) engage networks of transcriptional regulators to induce genes essential for antimicrobial immunity. We report that NFAT5, previously characterized as an osmostress responsive factor, regulates ...
  • Tejedor Vaquero, Sonia (Universitat Pompeu Fabra, 2019-01-08)
    Glucose is a key nutrient for T cells. Despite that T cell activation is impaired when they are deprived of glucose, it has also been shown that T effector responses can be elicited in vivo in glucose-poor environments, ...
  • Buxadé Fortuny, Maria; Huerga Encabo, Hector, 1989-; Riera-Borrull, Marta; Quintana-Gallardo, Lucía; López-Cotarelo, Pilar; Tellechea Recarte, Mónica, 1989-; Martínez-Martínez, Sara; Redondo, Juan Miguel; Martín Caballero, Juan; Flores, Juana M.; Bosch Fusté, Elena; Rodríguez-Fernández, José Luis; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2018)
    MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses. Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type-specific promoters. ...
  • Traveset Martínez, Laia (Universitat Pompeu Fabra, 2020-12-09)
    Maintenance of steady-state and stress-adapted hematopoiesis depends on the fitness of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Hematopoietic stem cells (HSCs) can adapt to stress by expanding ...
  • Muhammad, Khalid; Xavier, Delicia; Klein-Hessling, Stefan; Azeem, Muhammad; Rauschenberger, Tabea; Murti, Krisna; Avots, Andris; Goebeler, Matthias; Klein, Matthias; Bopp, Tobias; Sielaff, Malte; Tenzer, Stefan; Möckel, Sigrid; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina; Kerstan, Andreas; Serfling, Edgar (Frontiers, 2021)
    The skin protects the human body against dehydration and harmful challenges. Keratinocytes (KCs) are the most abundant epidermal cells, and it is anticipated that KC-mediated transport of Na+ ions creates a physiological ...
  • Tellechea Recarte, Mónica, 1989-; Buxadé Fortuny, Maria; Tejedor Vaquero, Sonia, 1988-; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (American Association of Immunologists - AAI, 2018)
    Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in their microenvironment. This functional plasticity ...
  • Higuera González, Laura (2021-10-29)
    Macrophages play crucial roles in the defense of the organism against a wide range of pathogens. Macrophages can rapidly adapt to perturbations in the microenvironment due to the existence of a network of transcription ...
  • Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Frontiers, 2019)
    The transcription factor NFAT5, also known as TonEBP, belongs to the family of Rel homology domain-containing factors, which comprises the NF-κB proteins and the calcineurin-dependent NFAT1 to NFAT4. NFAT5 shares several ...
  • Alberdi Ibarzabal, Maria (Universitat Pompeu Fabra, 2018-04-12)
    CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...
  • Tellechea Recarte, Mónica (Universitat Pompeu Fabra, 2018-06-12)
    Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in the microenvironment. This functional plasticity involves ...
  • Essig, Katharina; Kronbeck, Nina; Guimaraes, Joao C.; Lohs, Claudia; Schlundt, Andreas; Hoffmann, Anne; Behrens, Gesine; Brenner, Sven; Kowalska, Joanna; López Rodríguez, M. Cristina; Jemielity, Jacek; Holtmann, Helmut; Reiche, Kristin; Hackermüller, Jörg; Sattler, Michael; Zavolan, Mihaela; Heissmeyer, Vigo (Nature Research, 2018)
    The RNA-binding proteins Roquin-1 and Roquin-2 redundantly control gene expression and cell-fate decisions. Here, we show that Roquin not only interacts with stem-loop structures, but also with a linear sequence element ...

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