Browsing by Author "López Rodríguez, M. Cristina"

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  • Lunazzi, Giulia, 1981- (Universitat Pompeu Fabra, 2013-06-06)
  • Morancho Armisen, Beatriz; Minguillón Pedreño, Jordi; Molkentin, Jeffery D.; López Rodríguez, M. Cristina; Aramburu, José (Aramburu Beltrán) (BioMed Central, 2008)
    Background: The transcription factor NFAT5/TonEBP regulates the response of mammalian cells to hypertonicity. However, little is known about the physiopathologic tonicity thresholds that trigger its transcriptional activity ...
  • Huerga Encabo, Hector, 1989- (Universitat Pompeu Fabra, 2019-01-18)
  • Minguillón Pedreño, Jordi (Universitat Pompeu Fabra, 2008-01-04)
    El NFAT5 es un factor de transcripción de la familia Rel, la cual incluye a los NFATc y los NF-[kappa]B. Hasta ahora, el NFAT5 había sido caracterizado principalmente como un factor de respuesta a estrés osmótico ya que ...
  • Alberdi Ibarzabal, Maria, 1986-; Iglesias, Marcos; Tejedor Vaquero, Sonia, 1988-; Merino, Ramón; López Rodríguez, M. Cristina; Aramburu, José (Aramburu Beltrán) (Nature Publishing Group, 2017)
    Stress-activated transcription factors influence T-cell function in different physiopathologic contexts. NFAT5, a relative of nuclear factor κB and the calcineurin-activated NFATc transcription factors, protects mammalian ...
  • Buxadé Fortuny, Maria; Lunazzi, Giulia; Minguillón Pedreño, Jordi; Iborra, Salvador; Berga-Bolaños, Rosa; Del Val, Margarita; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2012)
    Toll-like receptors (TLRs) engage networks of transcriptional regulators to induce genes essential for antimicrobial immunity. We report that NFAT5, previously characterized as an osmostress responsive factor, regulates ...
  • Tejedor Vaquero, Sonia, 1988- (Universitat Pompeu Fabra, 2018-03-16)
    Glucose is a key nutrient for T cells. Despite that T cell activation is impaired when they are deprived of glucose, it has also been shown that T effector responses can be elicited in vivo in glucose-poor environments, ...
  • Buxadé Fortuny, Maria; Huerga Encabo, Hector, 1989-; Riera-Borrull, Marta; Quintana-Gallardo, Lucía; López-Cotarelo, Pilar; Tellechea Recarte, Mónica, 1989-; Martínez-Martínez, Sara; Redondo, Juan Miguel; Martín Caballero, Juan; Flores, Juana M.; Bosch, Elena; Rodríguez-Fernández, José Luis; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2018)
    MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses. Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type-specific promoters. ...
  • Tellechea Recarte, Mónica, 1989-; Buxadé Fortuny, Maria; Tejedor Vaquero, Sonia, 1988-; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (American Association of Immunologists - AAI, 2018)
    Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in their microenvironment. This functional plasticity ...
  • Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Frontiers, 2019)
    The transcription factor NFAT5, also known as TonEBP, belongs to the family of Rel homology domain-containing factors, which comprises the NF-κB proteins and the calcineurin-dependent NFAT1 to NFAT4. NFAT5 shares several ...
  • Alberdi Ibarzabal, Maria, 1986- (Universitat Pompeu Fabra, 2015-07-24)
    CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...
  • Tellechea Recarte, Mónica, 1989- (Universitat Pompeu Fabra, 2017-05-19)
    Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in the microenvironment. This functional plasticity involves ...
  • Essig, Katharina; Kronbeck, Nina; Guimaraes, Joao C.; Lohs, Claudia; Schlundt, Andreas; Hoffmann, Anne; Behrens, Gesine; Brenner, Sven; Kowalska, Joanna; López Rodríguez, M. Cristina; Jemielity, Jacek; Holtmann, Helmut; Reiche, Kristin; Hackermüller, Jörg; Sattler, Michael; Zavolan, Mihaela; Heissmeyer, Vigo (Nature Research, 2018)
    The RNA-binding proteins Roquin-1 and Roquin-2 redundantly control gene expression and cell-fate decisions. Here, we show that Roquin not only interacts with stem-loop structures, but also with a linear sequence element ...
  • Huerga Encabo, Hector, 1989-; Traveset, Laia; Argilaguet Marqués, Jordi, 1977-; Angulo, Ana; Nistal-Villán, Estanislao; Jaiswal, Rahul; Escalante, Carlos R.; Gekas, Christos; Meyerhans, Andreas; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2020)
    Type I interferon (IFN-I) provides effective antiviral immunity but can exacerbate harmful inflammatory reactions and cause hematopoietic stem cell (HSC) exhaustion; therefore, IFN-I expression must be tightly controlled. ...
  • López Rodríguez, M. Cristina; Aramburu, José (Aramburu Beltrán); Berga-Bolaños, Rosa (Springer, 2015)
    Almost 30 years ago pioneering work by the laboratories of Harald von Boehmer and Susumo Tonegawa provided the first indications that developing thymocytes could assemble a functional TCRβ chain-containing receptor complex, ...
  • Ortells Campos, Mª Carmen, 1984-; Morancho Armisen, Beatriz; Drews-Elger, Katherine, 1978-; Viollet, Benoit; Laderoute, Keith R; López Rodríguez, M. Cristina; Aramburu, José (Aramburu Beltrán) (Oxford University Press, 2012)
    Although stress can suppress growth and proliferation, cells can induce adaptive responses that allow them to maintain these functions under stress. While numerous studies have focused on the inhibitory effects of stress ...