Browsing by Author "López Bigas, Núria"

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  • Vidal Ocabo, Enrique; Sayols, Sergi; Moran, Sebastian; Guillaumet-Adkins, Amy; Schroeder, Michael Philipp, 1986-; Royo, Romina; Orozco, Modesto; Gut, Marta; Gut, Ivo Glynne; López Bigas, Núria; Heyn, Holger; Esteller, Manel (Nature Publishing Group, 2017)
    Although single base-pair resolution DNA methylation landscapes for embryonic and different somatic cell types provided important insights into epigenetic dynamics and cell-type specificity, such comprehensive profiling ...
  • Iorio, Francesco Iorio; Tamborero Noguera, David; López Bigas, Núria; Esteller, Manel; Garnett, Mathew J. (Elsevier, 2016)
    Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here, ...
  • Frigola, Joan; Iturbide Martínez de Albéniz, Ane, 1989-; López Bigas, Núria; Peiró Sales, Sandra; González-Pérez, Abel (Impact Journals, 2016)
    Chromatin regulatory factors (CRFs), are known to be involved in tumorigenesis in several cancer types. Nevertheless, the molecular mechanisms through which driver alterations of CRFs cause tumorigenesis remain unknown. ...
  • Mascarell Creus, Albert; López Bigas, Núria; Caño Delgado, Ana I. (BioMed Central, 2009)
    Background: Melon (Cucumis melo) is a horticultural specie of significant nutritional value, which belongs to the Cucurbitaceae family, whose economic importance is second only to the Solanaceae. Its small genome of approx. ...
  • Schroeder, Michael Philipp, 1986- (Universitat Pompeu Fabra, 2014-11-21)
    Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation of cancer genomics ...
  • Hernando, Henar; Shannon Lowe, Claire; Islam, Abul, 1978-; Al-Shahrour, Fátima; Rodríguez Ubreva, Javier; Rodríguez Cortez, Virginia C; Javierre, Biola M.; Mangas, Cristina; Fernández, Agustín F.; Parra, Maribel; Delecluse, Henri Jacques; Esteller, Manel; López Granados, Eduardo; Fraga, Mario F.; López Bigas, Núria; Ballestar, Esteban (BioMed Central, 2013)
    Background: Epstein-Barr virus (EBV) infection is a well characterized etiopathogenic factor for a variety of immune-related conditions, including lymphomas, lymphoproliferative disorders and autoimmune diseases. EBV-mediated ...
  • Guberman, Jonathan M.; Gundem, Gunes; López Bigas, Núria; Pérez Llamas, Christian, 1976-; Kasprzyk, Arek (Oxford University Press, 2011)
    BioMart Central Portal is a first of its kind, community-driven effort to provide unified access to dozens of biological databases spanning genomics, proteomics, model organisms, cancer data, ontology information and more. ...
  • Barneda Zahonero, Bruna; Román González, Lidia; Collazo, Olga; Rafati, Haleh; Islam, Abul, 1978-; Bussmann, Lars; Di Tullio, Alessandro, 1982-; Andrés, Luisa De; Graf, T. (Thomas); López Bigas, Núria; Mahmoudi, Tokameh; Parra, Maribel (Universitat Pompeu Fabra, 2013-05)
    HDAC7 is a repressor of myeloid genes whose downregulation in pre-B cells is required for transdifferentiation into macrophages.
  • Tamborero Noguera, David; Rubio Pérez, Carlota; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets, Ignasi; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria (Universitat Pompeu Fabra, 2016-10-17)
    The cancer bioMarkers database is curated and maintained by several clinical and scientific experts in the field of precision oncology supported by the European Union’s Horizon 2020 funding. This database is currently being ...
  • Tamborero Noguera, David; Rubio Pérez, Carlota, 1990-; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets Trias de Bes, Ignacio; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Torres, Carmen de; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria (BioMed Central, 2018)
    While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a ...
  • Furney, Simon J.; Madden, Stephen F.; Kisiel, Tomasz A.; Higgins, Desmond G.; López Bigas, Núria (Universitat Pompeu Fabra, 2007-12)
    Cancer gene properties.
  • Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Vona, Chiara Di; Bezdan, Daniela; Islam, Abul, 1978-; Salichs Fradera, Eulàlia; López Bigas, Núria; Ossowski, Stephan; Luna, Susana de la (Elsevier, 2015)
    DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and in tissue homeostasis, and its dysregulation results in human pathologies. DYRK1A is present in both the nucleus and cytoplasm of ...
  • Hernández-Sánchez, María; Kotaskova, Jana; Rodríguez, Ana E.; Radova, Lenka; Tamborero Noguera, David; Abáigar, María; Plevova, Karla; Benito, Rocío; Tom, Nikola; Quijada-Álamo, Miguel; Bikos, Vasileos; Martín, Ana África; Pal, Karol; García de Coca, Alfonso; Doubek, Michael; López Bigas, Núria; Hernández-Rivas, Jesús María; Pospisilova, Sarka (Nature Research, 2019)
  • Islam, Abul, 1978-; Richter, William F.; Jacobs, Laura A.; López Bigas, Núria; Benevolenskaya, Elizaveta V. (Public Library of Science (PLoS), 2011)
    Cancer is characterized by aberrant patterns of expression of multiple genes. These major shifts in gene expression are believed to be due to not only genetic but also epigenetic changes. The epigenetic changes are ...
  • Porta-Pardo, Eduard; Kamburov, Atanas; Tamborero Noguera, David; Pons, Tirso; Grases, Daniela; Valencia, Alfonso; López Bigas, Núria; Getz, Gad; Godzik, Adam (Nature Publishing Group, 2017)
    Understanding genetic events that lead to cancer initiation and progression remains one of the biggest challenges in cancer biology. Traditionally, most algorithms for cancer-driver identification look for genes that have ...
  • Tamborero Noguera, David; González-Pérez, Abel; Pérez Llamas, Christian, 1976-; Déu Pons, Jordi; Kandoth, Cyriac; Reimand, Jüri; Lawrence, Michael S.; Getz, Gad; Bader, Gary D.; Ding, Li; López Bigas, Núria (Nature Publishing Group, 2013)
    With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous ...
  • Pérez Llamas, Christian, 1976- (Universitat Pompeu Fabra, 2015-12-18)
    Given the complexity and heterogeneity of cancer, the development of new high-throughput wide-genome technologies has open new possibilities for its study. Several projects around the globe are exploiting these technologies ...
  • González-Pérez, Abel; López Bigas, Núria (Nature Research, 2013)
    The International Cancer Genome Consortium (ICGC) aims to catalog genomic abnormalities in tumors from 50 different cancer types. Genome sequencing reveals hundreds to thousands of somatic mutations in each tumor but only ...
  • Gundem, Gunes (Universitat Pompeu Fabra, 2011-09-29)
    In my thesis, I focused on integrative analysis of high-throughput oncogenomic data. This was done in two parts: In the first part, I describe IntOGen, an integrative data mining tool for the study of cancer. This system ...