Browsing by Author "López Bigas, Núria"

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  • A DNA methylation map of human cancer at single base-pair resolution
    Vidal Ocabo, Enrique; Sayols, Sergi; Moran, Sebastian; Guillaumet-Adkins, Amy; Schroeder, Michael Philipp, 1986-; Royo, Romina; Orozco, Modesto; Gut, Marta; Gut, Ivo Glynne; López Bigas, Núria; Heyn, Holger; Esteller, Manel (Nature Publishing Group, 2017)
    Although single base-pair resolution DNA methylation landscapes for embryonic and different somatic cell types provided important insights into epigenetic dynamics and cell-type specificity, such comprehensive profiling ...
  • A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer
    Wagner, Alex H.; Tamborero Noguera, David; López Bigas, Núria; Variant Interpretation for Cancer Consortium (Nature Research, 2020)
    Precision oncology relies on accurate discovery and interpretation of genomic variants, enabling individualized diagnosis, prognosis and therapy selection. We found that six prominent somatic cancer variant knowledgebases ...
  • A Landscape of Pharmacogenomic Interactions in Cancer.
    Iorio, Francesco Iorio; Tamborero Noguera, David; López Bigas, Núria; Esteller, Manel; Garnett, Mathew J. (Elsevier, 2016)
    Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here, ...
  • Altered oncomodules underlie chromatin regulatory factors driver mutations.
    Frigola, Joan; Iturbide Martínez de Albéniz, Ane, 1989-; López Bigas, Núria; Peiró Sales, Sandra; González-Pérez, Abel (Impact Journals, 2016)
    Chromatin regulatory factors (CRFs), are known to be involved in tumorigenesis in several cancer types. Nevertheless, the molecular mechanisms through which driver alterations of CRFs cause tumorigenesis remain unknown. ...
  • An oligo-based microarray offers novel transcriptomic approaches for the analysis of pathogen resistance and fruit quality traits in melon (Cucumis melo L.)
    Mascarell Creus, Albert; López Bigas, Núria; Caño Delgado, Ana I. (BioMed Central, 2009)
    Background: Melon (Cucumis melo) is a horticultural specie of significant nutritional value, which belongs to the Cucurbitaceae family, whose economic importance is second only to the Solanaceae. Its small genome of approx. ...
  • Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
    Rheinbay, Esther; Sabarinathan, Radhakrishnan; Mularoni, Loris; Gonzalez-Perez, Abel; Pich, Oriol; Tamborero Noguera, David; López Bigas, Núria; Getz, Gad; PCAWG Consortium (Nature Research, 2020)
    The discovery of drivers of cancer has traditionally focused on protein-coding genes1-4. Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from the ...
  • Analysis and visualization of multidimensional cancer genomics data
    Schroeder, Michael Philipp (Universitat Pompeu Fabra, 2015-07-28)
    Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation of cancer genomics ...
  • Assessment of human SARS CoV-2-Specific T-Cell responses elicited In Vitro by new computationally designed mRNA immunogens (COVARNA)
    Esteban, Ignasi; Pastor-Quiñones, Carmen; Usero, Lorena; Aurrecoechea, Elena; Franceschini, Lorenzo; Esprit, Arthur; Gelpí, Josep Lluís; Martínez-Jiménez, Francisco, 1988-; López Bigas, Núria; Breckpot, Karine; Thielemans, Kris; Leal, Lorna; Gómez, Carmen Elena; Sisteré-Oró, Marta; Meyerhans, Andreas; Esteban, Mariano; Alonso Fernández, María José; García, Felipe; Plana, Montserrat; COVARNA Consortium (MDPI, 2023)
    The COVID-19 pandemic has brought significant changes and advances in the field of vaccination, including the implementation and widespread use of encapsidated mRNA vaccines in general healthcare practice. Here, we present ...
  • The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion
    Hernando, Henar; Shannon Lowe, Claire; Islam, Abul, 1978-; Al-Shahrour, Fátima; Rodríguez Ubreva, Javier; Rodríguez Cortez, Virginia C; Javierre, Biola M.; Mangas, Cristina; Fernández, Agustín F.; Parra, Maribel; Delecluse, Henri Jacques; Esteller, Manel; López Granados, Eduardo; Fraga, Mario F.; López Bigas, Núria; Ballestar, Esteban (BioMed Central, 2013)
    Background: Epstein-Barr virus (EBV) infection is a well characterized etiopathogenic factor for a variety of immune-related conditions, including lymphomas, lymphoproliferative disorders and autoimmune diseases. EBV-mediated ...
  • BioMart Central Portal: an open database network for the biological community
    Guberman, Jonathan M.; Gundem, Gunes; López Bigas, Núria; Pérez Llamas, Christian, 1976-; Kasprzyk, Arek (Oxford University Press, 2011)
    BioMart Central Portal is a first of its kind, community-driven effort to provide unified access to dozens of biological databases spanning genomics, proteomics, model organisms, cancer data, ontology information and more. ...
  • BnpC: Bayesian non-parametric clustering of single-cell mutation profiles
    Borgsmüller, Nico; Bonet, Jose; Marass, Francesco; González Pérez, Abel; López Bigas, Núria; Beerenwinkel, Nico (Oxford University Press, 2020)
    Motivation: The high resolution of single-cell DNA sequencing (scDNA-seq) offers great potential to resolve intratumor heterogeneity (ITH) by distinguishing clonal populations based on their mutation profiles. However, the ...
  • C10-HDAC7
    Barneda Zahonero, Bruna; Román González, Lidia; Collazo, Olga; Rafati, Haleh; Islam, Abul, 1978-; Bussmann, Lars; Di Tullio, Alessandro, 1982-; Andrés, Luisa De; Graf, T. (Thomas); López Bigas, Núria; Mahmoudi, Tokameh; Parra, Maribel (Universitat Pompeu Fabra, 2013-05)
    HDAC7 is a repressor of myeloid genes whose downregulation in pre-B cells is required for transdifferentiation into macrophages.
  • Cancer bioMarkers database
    Tamborero Noguera, David; Rubio Pérez, Carlota; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets, Ignasi; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria (Universitat Pompeu Fabra, 2016-10-17)
    The cancer bioMarkers database is curated and maintained by several clinical and scientific experts in the field of precision oncology supported by the European Union’s Horizon 2020 funding. This database is currently being ...
  • Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
    Tamborero Noguera, David; Rubio Pérez, Carlota, 1990-; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets Trias de Bes, Ignacio; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Torres, Carmen de; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria (BioMed Central, 2018)
    While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a ...
  • CGProp
    Furney, Simon J.; Madden, Stephen F.; Kisiel, Tomasz A.; Higgins, Desmond G.; López Bigas, Núria (Universitat Pompeu Fabra, 2007-12)
    Cancer gene properties.
  • Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer
    Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase
    Vona, Chiara Di; Bezdan, Daniela; Islam, Abul, 1978-; Salichs Fradera, Eulàlia; López Bigas, Núria; Ossowski, Stephan; Luna, Susana de la (Elsevier, 2015)
    DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and in tissue homeostasis, and its dysregulation results in human pathologies. DYRK1A is present in both the nucleus and cytoplasm of ...
  • CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
    Griffith, Malachi; López Bigas, Núria; Griffith, Obi L. (Nature Research, 2017)
    CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of inherited and somatic variants of all types. ...
  • CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase
    Hernández-Sánchez, María; Kotaskova, Jana; Rodríguez, Ana E.; Radova, Lenka; Tamborero Noguera, David; Abáigar, María; Plevova, Karla; Benito, Rocío; Tom, Nikola; Quijada-Álamo, Miguel; Bikos, Vasileos; Martín, Ana África; Pal, Karol; García de Coca, Alfonso; Doubek, Michael; López Bigas, Núria; Hernández-Rivas, Jesús María; Pospisilova, Sarka (Nature Research, 2019)
  • Clustering of somatic mutations across cancer genomes
    Arnedo Pac, Claudia Rosario (Universitat Pompeu Fabra, 2023-01-10)
    Sequencing of cancer genomes reveals the story of mutational events shaping the distribution of somatic mutations across the nucleotide sequence. A particular pattern of such distribution, mutational clustering, can inform ...

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