Browsing by Author "Kringelbach, Morten L."

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  • Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder
    Figueroa, Caroline A.; Cabral, Joana; Mocking, Roeal J.T.; Rapuano, Kristina M.; Van Hartevelt, Tim J.; Deco, Gustavo; Expert, Paul; Schene, Aart H.; Kringelbach, Morten L.; Ruhé, Henricus G. (Wiley, 2019)
    Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” functional connectivity (FC). Knowing that ...
  • Awakening: Predicting external stimulation to force transitions between different brain states
    Deco, Gustavo; Cruzat Grand, Josefina, 1983-; Cabral, Joana; Tagliazucchi, Enzo; Laufs, Helmut; Logothetis, Nikos K.; Kringelbach, Morten L. (National Academy of Sciences, 2019)
    A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires ...
  • Brain songs framework used for discovering the relevant timescale of the human brain
    Deco, Gustavo; Cruzat Grand, Josefina, 1983-; Kringelbach, Morten L. (Nature Research, 2019)
    A key unresolved problem in neuroscience is to determine the relevant timescale for understanding spatiotemporal dynamics across the whole brain. While resting state fMRI reveals networks at an ultraslow timescale (below ...
  • Brain states and transitions: insights from computational neuroscience
    Kringelbach, Morten L.; Deco, Gustavo (Elsevier, 2020)
    Within the field of computational neuroscience there are great expectations of finding new ways to rebalance the complex dynamic system of the human brain through controlled pharmacological or electromagnetic perturbation. ...
  • Breakdown of whole-brain dynamics in preterm-born children
    Padilla, Nelly; Saenger Amoore, Victor Manuel; Van Hartevelt, Tim J.; Fernandes, Henrique M.; Lennartsson, Finn; Andersson, Jesper L. R.; Kringelbach, Morten L.; Deco, Gustavo; Åden, Ulrika (Oxford University Press, 2019)
    The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support ...
  • Bridging the gap between single receptor type activity and whole-brain dynamics
    Jancke, Dirk; Herlitze, Stefan; Kringelbach, Morten L.; Deco, Gustavo (Wiley, 2022)
    What is the effect of activating a single modulatory neuronal receptor type on entire brain network dynamics? Can such effect be isolated at all? These are important questions because characterizing elementary neuronal ...
  • Capturing the non-stationarity of whole-brain dynamics underlying human brain states
    Galadí, Javier Alejandro; Silva Pereira, Silvana; Sanz Per, Yonatan; Kringelbach, Morten L.; Gayte, Inmaculada; Lauf, Helmut; Tagliazucchi, Enzo; Langa, Jose Antonio; Deco, Gustavo (Elsevier, 2021)
    Brain dynamics depicts an extremely complex energy landscape that changes over time, and its characterisation is a central unsolved problem in neuroscience. We approximate the non-stationary landscape sustained by the human ...
  • Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
    Cabral, Joana; Vidaurre, Diego; Marques, Paulo; Magalhães, Ricardo; Moreira, Pedro Silva; Soares, José Miguel; Deco, Gustavo; Sousa, Nuno; Kringelbach, Morten L. (Nature Research, 2017)
    Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, ...
  • Complex spatiotemporal oscillations emerge from transverse instabilities in large-scale brain networks
    Clusella, Pau; Deco, Gustavo; Kringelbach, Morten L.; Ruffini, Giulio; García Ojalvo, Jordi (Public Library of Science (PLoS), 2023)
    Spatiotemporal oscillations underlie all cognitive brain functions. Large-scale brain models, constrained by neuroimaging data, aim to trace the principles underlying such macroscopic neural activity from the intricate and ...
  • Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD
    Atasoy, Selen; Roseman, Leor; Kaelen, Mendel; Kringelbach, Morten L.; Deco, Gustavo; Carhart-Harris, Robin L. (Nature Research, 2017)
    Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used ’connectome-harmonic decomposition’, a novel ...
  • Decoding brain states on the intrinsic manifold of human brain dynamics across wakefulness and sleep
    Rué-Queralt, Joan; Stevner, Angus; Tagliazucchi, Enzo; Laufs, Helmut; Kringelbach, Morten L.; Deco, Gustavo; Atasoy, Selen (Nature Research, 2021)
    Current state-of-the-art functional magnetic resonance imaging (fMRI) offers remarkable imaging quality and resolution, yet, the intrinsic dimensionality of brain dynamics in different states (wakefulness, light and deep ...
  • Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep
    Stevner, Angus B. A.; Vidaurre, Diego; Cabral, Joana; Rapuano, Kristina M.; Nielsen, Søren Føns Vind; Tagliazucchi, Enzo; Laufs, Helmut; Vuust, Peter; Deco, Gustavo; Woolrich, Mark W.; van Someren, Eus; Kringelbach, Morten L. (Nature Research, 2019)
    The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move ...
  • Disrupted brain structural connectivity in pediatric bipolar disorder with psychosis
    Fernandes, Henrique M.; Cabral, Joana; Van Hartevelt, Tim J.; Lord, Louis-David; Gleesborg, Carsten; Møller, Arne; Deco, Gustavo; Whybrow, Peter C.; Petrovic, Predrag; James, Anthony C.; Kringelbach, Morten L. (Nature Research, 2019)
    Bipolar disorder (BD) has been linked to disrupted structural and functional connectivity between prefrontal networks and limbic brain regions. Studies of patients with pediatric bipolar disorder (PBD) can help elucidate ...
  • Distinct criticality of phase and amplitude dynamics in the resting brain
    Daffertshofer, Andreas; Ton, Robert; Kringelbach, Morten L.; Woolrich, Mark; Deco, Gustavo (Elsevier, 2018)
    Converging research suggests that the resting brain operates at the cusp of dynamic instability, as signified by scale-free temporal correlations. We asked whether the scaling properties of these correlations differ between ...
  • Distributed harmonic patterns of structure-function dependence orchestrate human consciousness
    Luppi, Andrea I.; Vohryzek, Jakub; Kringelbach, Morten L.; Martinez Mediano, Pedro Antonio; Adapa, Ram; Carhart-Harris, Robin L.; Roseman, Leor; Pappas, Ioannis; Peattie, Alexander R. D.; Manktelow, Anne E.; Sahakian, Barbara J.; Finoia, Paola; Williams, Guy B.; Allanson, Judith; Pickard, John D.; Menon, David K.; Atasoy, Selen; Stamatakis, Emmanuel A. (Nature Research, 2023)
    A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations ...
  • Dynamic coupling of whole-brain neuronal and neurotransmitter systems
    Kringelbach, Morten L.; Cruzat Grand, Josefina, 1983-; Cabral, Joana; Moos Knudsen, Gitte; Carhart-Harris, Robin L.; Whybrow, Peter C.; Logothetis, N.; Deco, Gustavo (National Academy of Sciences, 2020)
    Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich ...
  • Dynamic sensitivity analysis: defining personalised strategies to drive brain state transitions via whole brain modelling
    Vohryzek, Jakub; Cabral, Joana; Castaldo, Francesca; Sanz-Perl, Yonatan; Lord, Louis-David; Fernandes, Henrique M.; Litvak, Vladimir; Kringelbach, Morten L.; Deco, Gustavo (Elsevier, 2023)
    Traditionally, in neuroimaging, model-free analyses are used to find significant differences between brain states via signal detection theory. Depending on the a priori assumptions about the underlying data, different ...
  • Dynamical consequences of regional heterogeneity in the brain’s transcriptional landscape
    Deco, Gustavo; Kringelbach, Morten L.; Arnatkeviciute, Aurina; Oldham, Stuart; Sabaroedin, Kristina; Rogasch, Nigel C.; Aquino, Kevin; Fornito, Alex (American Association for the Advancement of Science (AAAS), 2021)
    Brain regions vary in their molecular and cellular composition, but how this heterogeneity shapes neuronal dynamics is unclear. Here, we investigate the dynamical consequences of regional heterogeneity using a biophysical model ...
  • Effects of classic psychedelic drugs on turbulent signatures in brain dynamics
    Cruzat Grand, Josefina, 1983-; Sanz Perl, Yonatan; Escrichs, Anira; Vohryzek, Jakub; Timmermann, Christopher; Roseman, Leor; Luppi, Andrea I.; Ibañez, Agustin; Nutt, David; Carhart-Harris, Robin L.; Tagliazucchi, Enzo; Deco, Gustavo; Kringelbach, Morten L. (MIT Press, 2022)
    Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently ...
  • Evidence from a rare case study for Hebbian-like changes in structural connectivity induced by long-term deep brain stimulation
    Van Hartevelt, Tim J.; Cabral, Joana; Møller, Arne; FitzGerald, James J.; Green, Alex L.; Deco, Gustavo; Kringelbach, Morten L. (Frontiers, 2015)
    It is unclear whether Hebbian-like learning occurs at the level of long-range white matter connections in humans, i.e., where measurable changes in structural connectivity (SC) are correlated with changes in functional ...