Browsing by Author "Koppelman, Gerard H."

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  • Distinction between rhinitis alone and rhinitis with asthma using interactomics
    Aguilar, Daniel; Lemonnier, Nathanael; Melén, Erik; Bustamante Pineda, Mariona; Gruzieva, Olena; Guerra, Stefano; Keil, Thomas; Koppelman, Gerard H.; Celedón, Juan C.; Antó i Boqué, Josep Maria; Bousquet, Jean (Nature Research, 2023)
    The concept of "one-airway-one-disease", coined over 20 years ago, may be an over-simplification of the links between allergic diseases. Genomic studies suggest that rhinitis alone and rhinitis with asthma are operated by ...
  • DNA methylation in childhood asthma: an epigenome-wide meta-analysis
    Xu, Cheng-Jian; Bustamante Pineda, Mariona; García Aymerich, Judith; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Koppelman, Gerard H. (Elsevier, 2018)
    Background: DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with childhood ...
  • Genetic and epigenetic regulation of YKL-40 in childhood
    Guerra, Stefano; Sunyer Deu, Jordi; Lavi, Iris; Benet, Marta; Bustamante Pineda, Mariona; Carsin, Anne-Elie; Dobaño, Carlota; Guxens Junyent, Mònica; Tischer, Christina; Vrijheid, Martine; Antó i Boqué, Josep Maria; Koppelman, Gerard H. (Elsevier, 2018)
    Background: Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic variation in its encoding gene (chitinase 3–like 1 [CHI3L1]) and are increased in patients with several diseases, including ...
  • Increased risk of asthma in overweight children born large for gestational age
    Pinto, Leonardo A.; Guerra, Stefano; Antó i Boqué, Josep Maria; Postma, Dirkje S.; Koppelman, Gerard H.; Jongste, Johan C. de; Gehring, Ulrike; Smit, Henriëtte A.; Wijga, Alet (Wiley, 2017)
    Background: Being born large for gestational age (LGA) is a marker of increased growth velocity in fetal life and a risk factor for childhood overweight. Both being born LGA and childhood overweight may influence the ...
  • Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
    Merid, Simon Kebede; Bustamante Pineda, Mariona; Standl, Marie; Sunyer Deu, Jordi; Heinrich, Joachim; Lemonnier, Nathanael; Aguilar, Daniel; Antó i Boqué, Josep Maria; Bousquet, Jean; Santa Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M.; Koppelman, Gerard H.; Melén, Erik; Gruzieva, Olena (Elsevier, 2020)
    Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...
  • Phenotyping asthma, rhinitis, and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster
    García Aymerich, Judith; Benet, Marta; Saeys, Y.; Pinart, Mariona; Basagaña Flores, Xavier; Smit, Henriëtte A.; Siroux, Valérie; Just, Jocelyne; Momas, Isabelle; Rancière, Fanny; Keil, Thomas; Hohmann, Cynthia; Lau, Susanne; Wahn, Ulrich; Heinrich, Joachim; Tischer, Christina; Fantini, Maria Pia; Lenzi, Jacopo; Porta, Daniela; Koppelman, Gerard H.; Postma, Dirkje S.; Berdel, Dietrich; Koletzko, Sibylle; Kerkhof, Marjan; Gehring, Ulrike; Wickman, Magnus; Melén, Erik; Hallberg, Jenny; Bindslev Jensen, Carsten; Eller, Esben; Kull, Inger; Lodrup Carlsen, Karin C.; Carlsen, Kai-Håkon; Lambrecht, Bart N.; Kogevinas, Manolis; Sunyer Deu, Jordi; Kauffmann, Francine; Bousquet, Jean; Antó i Boqué, Josep Maria (Wiley, 2015)
    BACKGROUND: Asthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using ...
  • Shared DNA methylation signatures in childhood allergy: The MeDALL study
    Xu, Cheng-Jian; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Kogevinas, Manolis; Sunyer Deu, Jordi; Koppelman, Gerard H. (Elsevier, 2021)
    Background: Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema. Objective: We sought to identify DNA methylation profiles ...
  • The emerging landscape of dynamic DNA methylation in early childhood
    Xu, Cheng-Jian; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Koppelman, Gerard H. (BioMed Central, 2017)
    Background: DNA methylation has been found to associate with disease, aging and environmental exposure, but it is unknown how genome, environment and disease influence DNA methylation dynamics in childhood. Results: By ...
  • Understanding allergic multimorbidity within the non-eosinophilic interactome
    Aguilar, Daniel; Lemonnier, Nathanael; Koppelman, Gerard H.; Melén, Erik; Oliva Miguel, Baldomero; Pinart, Mariona; Guerra, Stefano; Bousquet, Jean; Antó i Boqué, Josep Maria (Public Library of Science (PLoS), 2019)
    Background: The mechanisms explaining multimorbidity between asthma, dermatitis and rhinitis (allergic multimorbidity) are not well known. We investigated these mechanisms and their specificity in distinct cell types by ...