Browsing by Author "Konstantopoulos, Konstantinos"

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  • Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area
    Zhao, Runchen; Afthinos, Alexandros; Zhu, Tian; Mistriotis, Panagiotis; Li, Yizeng; Serra Pascual, Selma A., 1981-; Zhang, Yuqi; Yankaskas, Christopher L.; He, Shuyu; Valverde, M. A. (Miguel Ángel), 1963-; Sun, Sean X.; Konstantopoulos, Konstantinos (American Association for the Advancement of Science (AAAS), 2019)
    How cells sense hydraulic pressure and make directional choices in confinement remains elusive. Using trifurcating Ψ-like microchannels of different hydraulic resistances and cross-sectional areas, we discovered that the ...
  • Confinement sensing and signal optimization via Piezo1/PKA and myosin II pathways
    Hung, Wei-Chien; Yang, Jessica R.; Yankaskas, Christopher L.; Wong, Bin Sheng; Wu, Pei-Hsun; Pardo Pastor, Carlos; Serra Pascual, Selma A., 1981-; Chiang, Meng-Jung; Gu, Zhizhan; Wirtz, Denis; Valverde, M. A. (Miguel Ángel), 1963-; Zhang, Jin; Konstantopoulos, Konstantinos (Elsevier, 2016)
    Cells adopt distinct signaling pathways to optimize cell locomotion in different physical microenvironments. However, the underlying mechanism that enables cells to sense and respond to physical confinement is unknown. ...
  • Extracellular fluid viscosity enhances cell migration and cancer dissemination
    Bera, Kaustav; Serra, Selma A.; Valverde, M. A. (Miguel Ángel), 1963-; Konstantopoulos, Konstantinos (Nature Research, 2022)
    Cells respond to physical stimuli, such as stiffness1, fluid shear stress2 and hydraulic pressure3,4. Extracellular fluid viscosity is a key physical cue that varies under physiological and pathological conditions, such ...
  • Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
    Zhang, Yuqi; Li, Yizeng; Thompson, Keyata N.; Stoletov, Konstantin; Yuan, Qinling; Bera, Kaustav; Lee, Se Jong; Zhao, Runchen; Kiepas, Alexander; Wang, Yao; Mistriotis, Panagiotis; Serra, Selma A.; Lewis, John D.; Valverde, M. A. (Miguel Ángel), 1963-; Martin, Stuart S.; Sun, Sean X.; Konstantopoulos, Konstantinos (Nature Research, 2022)
    Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. According to the Osmotic Engine Model, polarization of NHE1 at the leading edge of confined cells facilitates water uptake, cell ...
  • The fluid shear stress sensor TRPM7 regulates tumor cell intravasation
    Yankaskas, Christopher L.; Bera, Kaustav; Stoletov, Konstantin; Serra, Selma A.; Carrillo García, Julia, 1993-; Tuntithavornwat, Soontorn; Mistriotis, Panagiotis; Lewis, John D.; Valverde, M. A. (Miguel Ángel), 1963-; Konstantopoulos, Konstantinos (American Association for the Advancement of Science (AAAS), 2021)
    Tumor cell intravasation preferentially occurs in regions of low fluid shear because high shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells avoid high shear during intravasation. ...