Browsing by Author "Keyes, William M., 1973-"

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  • Age-associated inflammation inhibits epidermal stem cell function
    Doles, Jason; Storer, Mekayla, 1981-; Cozzuto, Luca; Roma, Guglielmo; Keyes, William M., 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased ...
  • Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer
    Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Detection of senescence markers during mammalian embryonic development
    Storer, Mekayla, 1981-; Keyes, William M., 1973- (Humana Press (Springer Imprint), 2017)
    Senescence-associated β-galactosidase (SAβ-gal) is a convenient histological technique used to identify senescent cells. Its ease of use is helpful to initially screen and detect senescent cells in heterogeneous cell ...
  • Developing senescence to remodel the embryo
    Storer, Mekayla, 1981-; Keyes, William M., 1973- (Taylor & Francis, 2014)
    Cellular senescence is an irreversible form of cell cycle arrest that has been linked to several pathological conditions. In particular, senescence can function as a tumor suppressor mechanism, but is also thought to ...
  • Investigating a role for p63 in prostate stem cells, cancer and metastasis
    Di Giacomo, Valeria (Universitat Pompeu Fabra, 2016-05-18)
    P63 is a transcription factor of the p53 family with key roles in embryonic development, stem cells and cancer. P63-deficient mice fail to form stratified and glandular epithelia, including the prostate, demonstrating a ...
  • Investigating senescence in cellular plasticity and tissue regeneration
    Ritschka, Birgit (Universitat Pompeu Fabra, 2018-04-12)
    Cellular senescence has mainly been associated with tumor suppression and aging, mediated through cell intrinsic cell-cycle inhibition and arrest. However, through secretion of specific proteins, termed the senescence-associated ...
  • Investigating the roles of cellular senescence in embryogenesis and aging
    Storer, Mekayla (Universitat Pompeu Fabra, 2015-04-22)
    Cellular senescence is an irreversible form of proliferative arrest, historically linked to tumour suppression and aging. Recent discoveries, however, have extended its known role to include complex biological processes ...
  • Senescence is a developmental mechanism that contributes to embryonic growth and patterning
    Storer, Mekayla, 1981-; Mas Malavila, Alba; Robert Moreno, Alexandre; Pecoraro, Matteo, 1984-; Ortells Campos, Mª Carmen, 1984-; Giacomo, Valeria di; Yosef, Reut; Pilpel, Noam; Krizhanovsky, Valery; Sharpe, James; Keyes, William M., 1973- (Elsevier, 2013)
    Senescence is a form of cell-cycle arrest linked to tumor suppression and aging. However, it remains controversial and has not been documented in nonpathologic states. Here we describe senescence as a normal developmental ...
  • The Role of p63 and the chromatin remodeler Lsh in senescence, tumor development and lymphangiogenesis
    Pecoraro, Matteo (Universitat Pompeu Fabra, 2015-12-15)
    La senescencia celular es una detención irreversible del ciclo celular que tiene lugar en respuesta a diversos estímulos de estrés, actuando como un mecanismo supresor de tumores para impedir la proliferación de células ...
  • The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
    Ritschka, Birgit,1985-; Storer, Mekayla, 1981-; Mas Malavila, Alba; Heinzmann, Florian; Ortells Campos, Mª Carmen, 1984-; Morton, Jennifer P.; Sansom, Owen J.; Zender, Lars; Keyes, William M., 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of proteins collectively known as the senescence-associated secretory ...
  • The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice
    Ritschka, Birgit,1985-; Knauer-Meyer, Tania; Sampaio Gonçalves, Daniel; Mas, Alba; Plassat, Jean-Luc; Durik, Matej; Jacobs, Hugues; Pedone, Elisa, 1985-; Di Vicino, Umberto; Cosma, Maria Pia, 1970-; Keyes, William M., 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)
    Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that ...
  • ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis
    Keyes, William M., 1973-; Pecoraro, Matteo, 1984-; Aranda, Victoria; Vernersson Lindahl, Emma; Li, Wangzhi; Vogel, Hannes; Guo, Xuecui; Garcia, Elvin L.; Michurina, Tatyana V.; Enikolopov, Grigori; Muthuswamy, Senthil K.; Mills, Alea A. (Elsevier, 2011)
    The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor-suppressive mechanism of cellular senescence, causing a striking absence of stratified ...
  • ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82
    Di Giacomo, Valeria, 1983-; Tian, Tian V.; Mas Malavila, Alba; Pecoraro, Matteo, 1984-; Batlle Morera, Laura; Noya Ferreiro, Lourdes; Martín Caballero, Juan; Ruberte, Jesús; Keyes, William M., 1973- (Springer, 2017)
    ΔNp63α is a critical mediator of epithelial development and stem cell function in a variety of tissues including the skin and breast, while overexpression of ΔNp63α acts as an oncogene to drive tumor formation and cancer ...

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