Browsing by Author "Keyes, William M., 1973-"

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  • Doles, Jason; Storer, Mekayla, 1981-; Cozzuto, Luca; Roma, Guglielmo; Keyes, William M., 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased ...
  • Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Storer, Mekayla, 1981-; Keyes, William M., 1973- (Humana Press (Springer Imprint), 2017)
    Senescence-associated β-galactosidase (SAβ-gal) is a convenient histological technique used to identify senescent cells. Its ease of use is helpful to initially screen and detect senescent cells in heterogeneous cell ...
  • Storer, Mekayla, 1981- (Universitat Pompeu Fabra, 2014-12-18)
    Cellular senescence is an irreversible form of proliferative arrest, historically linked to tumour suppression and aging. Recent discoveries, however, have extended its known role to include complex biological processes ...
  • Storer, Mekayla, 1981-; Mas Malavila, Alba; Robert Moreno, Alexandre; Pecoraro, Matteo, 1984-; Ortells Campos, Mª Carmen, 1984-; Giacomo, Valeria di; Yosef, Reut; Pilpel, Noam; Krizhanovsky, Valery; Sharpe, James; Keyes, William M., 1973- (Elsevier, 2013)
    Senescence is a form of cell-cycle arrest linked to tumor suppression and aging. However, it remains controversial and has not been documented in nonpathologic states. Here we describe senescence as a normal developmental ...
  • Pecoraro, Matteo, 1984- (Universitat Pompeu Fabra, 2014-10-02)
    La senescencia celular es una detención irreversible del ciclo celular que tiene lugar en respuesta a diversos estímulos de estrés, actuando como un mecanismo supresor de tumores para impedir la proliferación de células ...
  • Ritschka, Birgit,1985-; Knauer-Meyer, Tania; Sampaio Gonçalves, Daniel; Mas, Alba; Plassat, Jean-Luc; Durik, Matej; Jacobs, Hugues; Pedone, Elisa, 1985-; Di Vicino, Umberto; Cosma, Maria Pia, 1970-; Keyes, William M., 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)
    Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that ...