Browsing by Author "Keun, Hector C."

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  • Assessment of metabolic phenotypic variability in children’s urine using 1H NMR spectroscopy
    Maitre, Léa; Lau, Chung-Ho E.; Vizcaino, Esther; Robinson, Oliver; Casas Sanahuja, Maribel; Siskos, Alexandros P.; Want, Elizabeth J.; Athersuch, Toby J.; Slama, Rémy; Vrijheid, Martine; Keun, Hector C.; Coen, Muireann (Nature Research, 2017)
    The application of metabolic phenotyping in clinical and epidemiological studies is limited by a poor understanding of inter-individual, intra-individual and temporal variability in metabolic phenotypes. Using 1H NMR ...
  • Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort
    Robinson, Oliver; Lau, Chung-Ho E.; Joo, Sungyeon; Andrušaitytė, Sandra; Borràs, Eva; Prado Bert, Paula de; Chatzi, Lida Vaia; Keun, Hector C.; Gražulevičienė, Regina; Gutzkow, Kristine B.; Maitre, Léa; Martens, Dries S.; Sabidó Aguadé, Eduard, 1981-; Siroux, Valérie; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Bustamante Pineda, Mariona; Vrijheid, Martine (eLife, 2023)
    Background: While biological age in adults is often understood as representing general health and resilience, the conceptual interpretation of accelerated biological age in children and its relationship to development ...
  • Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
    Balcells Nadal, Cristina; Xu, Yitao; Gil Solsona, Rubén; Maitre, Léa; Gago Ferrero, Pablo; Keun, Hector C. (Elsevier, 2024)
    The aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed ...
  • Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: a panel study
    Fabbri, Lorenzo; Garlantézec, Ronan; Audouze, Karine; Bustamante Pineda, Mariona; Carracedo, Ángel; Chatzi, Leda; González, Juan Ramón; Gražulevičienė, Regina; Keun, Hector C.; Lau, Chung-Ho E.; Sabidó, Eduard; Siskos, Alexandros P.; Slama, Rémy; Thomsen, Cathrine; Wright, John; Yuan, Wen Lun; Casas, Maribel; Vrijheid, Martine; Maitre, Léa (Elsevier, 2023)
    Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused ...
  • Urinary metabolite quantitative trait loci in children and their interaction with dietary factors
    Calvo Serra, Beatriz; Maitre, Léa; Lau, Chung-Ho E.; Siskos, Alexandros P.; Gützkow, Kristine B.; Andrušaitytė, Sandra; Casas Sanahuja, Maribel; Cadiou, Solène; Chatzi, Leda; González, Juan Ramón; Gražulevičienė, Regina; McEachan, Rosemary R.C.; Slama, Rémy; Vafeiadi, Marina, 1983-; Wright, John; Coen, Muireann; Vrijheid, Martine; Keun, Hector C.; Escaramís, Geòrgia; Bustamante Pineda, Mariona (Oxford University Press, 2021)
    Human metabolism is influenced by genetic and environmental factors. Previous studies have identified over 23 loci associated with more than 26 urine metabolites levels in adults, which are known as urinary metabolite ...
  • Urine metabolic signatures of multiple environmental pollutants in pregnant women: an exposome approach
    Maitre, Léa; Robinson, Oliver; Martínez, David; Toledano, Mireille B.; Ibarluzea, Jesús; Marina, Loreto Santa; Sunyer Deu, Jordi; Villanueva, Cristina M.; Keun, Hector C.; Vrijheid, Martine; Coen, Muireann (American Chemical Society (ACS), 2018)
    Exposure to environmental pollutants, particularly during pregnancy, can have adverse consequences on child development but little is known about the effects of pollutant mixtures on endogenous metabolism in pregnant women. ...

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