Browsing by Author "Jung, Carole"

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  • Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility
    Núñez Ollé, Marc, 1984-; Jung, Carole; Terré, Berta; Balsiger, Norman A.; Plata, Cristina; Roset i Huguet, Ramon; Pardo Pastor, Carlos; Garrido, Marta; Rojas, Santiago; Alameda Quitllet, Francisco; Lloreta Trull, Josep, 1958-; Martín Caballero, Juan; Flores, Juana M.; Stracker, Travis; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964-; Gil Gómez, Gabriel (Impact Journals, 2017)
    Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple ...
  • DYRK1A kinase positively regulates angiogenic responses in endothelial cells
    Rozen, Esteban J.; Roewenstrunk, Julia Maria, 1981-; Barallobre, María José; Di Vona, Chiara, 1981-; Jung, Carole; Figueiredo, Ana F.; Luna, Jeroni; Fillat i Fonts, Cristina; Arbonés de Rafael, Maria Lourdes, 1959-; Graupera, Mariona; Valverde, M. A. (Miguel Ángel), 1963-; Luna Gargantilla, Susana de la (Elsevier, 2018)
    Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells ...
  • GEMC1 is a critical regulator of multiciliated cell differentiation.
    Terré, Berta; Piergiovanni, Gabriele; Segura-Bayona, Sandra; Gil Gómez, Gabriel; Youssef, Sameh A.; Attolini, Camille Stephan-Otto; Wilsch-Bräuninger, Michaela; Jung, Carole; Rojas Mendoza, Ana Maria; Marjanovi c, Marko; Knobel, Philip A.; Palenzuela, Lluís; López-Rovira, Teresa; Forrow, Stephen; Huttner, Wieland B.; Valverde, M. A. (Miguel Ángel), 1963-; de Bruin, Alain; Costanzo, Vincenzo; Stracker, Travis (EMBO Press, 2016)
    The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass ...
  • Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
    Sánchez, Alicia; Alvarez, Julio L.; Demydenko, Kateryna; Jung, Carole; Alpizar, Yeranddy A.; Alvárez Collazo, Julio; Cokic, Stevan M.; Valverde, M. A. (Miguel Ángel), 1963-; Hoet, Peter H.M.; Talavera, Karel (BioMed Central, 2017)
    BACKGROUND: Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents. However, the increasing exposure ...
  • TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
    Alpizar, Yeranddy A.; Boonen, Brett; Sánchez, Alicia; Jung, Carole; López-Requena, Alejandro; Naert, Robbe; Steelant, Brecht; Luyts, Katrien; Plata, Cristina; Vooght, Vanessa De; Vanoirbeek, Jeroen A.J.; Meseguer, Victor M.; Voets, Thomas; Alvarez, Julio L.; Hellings, Peter W.; Hoet, Peter H.M.; Nemery, Benoit; Valverde, M. A. (Miguel Ángel), 1963-; Talavera, Karel (Nature Publishing Group, 2017)
    Lipopolysaccharides (LPS), the major components of the wall of gram-negative bacteria, trigger powerful defensive responses in the airways via mechanisms thought to rely solely on the Toll-like receptor 4 (TLR4) immune ...