Browsing by Author "Juan, David"

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  • A comparative genomics multitool for scientific discovery and conservation
    Zoonomia Consortium; Serres Armero, Aitor, 1992-; Juan, David; Kuderna, Lukas F.K.; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2020)
    The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe ...
  • Comprehensive identification of somatic nucleotide variants in human brain tissue
    Wang, Yifan; Lobon, Irene; Juan, David; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975-; Abyzov, Alexej (BioMed Central, 2021)
    Background: Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. ...
  • Copy number variation underlies complex phenotypes in domestic dog breeds and other canids
    Serres Armero, Aitor, 1992-; Davis, Brian W.; Povolotskaya, Inna, 1986-; Morcillo Suárez, Carlos, 1969-; Plassais, Jocelyn; Juan, David; Ostrander, Elaine A.; Marquès i Bonet, Tomàs, 1975- (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    Extreme phenotypic diversity, a history of artificial selection, and socioeconomic value make domestic dog breeds a compelling subject for genomic research. Copy number variation (CNV) is known to account for a significant ...
  • Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures
    García Pérez, Raquel, 1989-; Esteller-Cucala, Paula; Mas, Glòria; Lobón, Irene; Di Carlo, Valerio; Riera, Meritxell; Kuhlwilm, Martin; Navarro i Cuartiellas, Arcadi, 1969-; Blancher, Antoine; Di Croce, Luciano; Gómez Skarmeta, José Luis; Juan, David; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2021)
    Changes in the epigenetic regulation of gene expression have a central role in evolution. Here, we extensively profiled a panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ...
  • Expanding the geographic characterisation of epstein-barr virus variation through gene-based approaches
    Telford, Marco, 1984-; Hughes, David; Juan, David; Stoneking, Mark; Navarro i Cuartiellas, Arcadi, 1969-; Santpere Baró, Gabriel, 1981- (MDPI, 2020)
    The Epstein-Barr Virus (EBV) infects the vast majority of human individuals worldwide (~90%) and is associated with several diseases, including different types of cancer and multiple sclerosis, which show wide variation ...
  • Selective single molecule sequencing and assembly of a human Y chromosome of African origin
    Kuderna, Lukas F.K.; Lizano González, Esther, 1974-; Julià, Eva; Gómez Garrido, Jèssica; Serres Armero, Aitor, 1992-; Kuhlwilm, Martin; Alandes, Regina Antoni; Alvarez-Estape, Marina; Juan, David; Simon, Heath; Alioto, Tyler; Gut, Marta; Gut, Ivo Glynne; Schierup, Mikkel H.; Fornas Carreño, Oscar; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2019)
    Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly difficulties, high repeat content, and large ampliconic regions, only a handful of species have their Y chromosome properly ...
  • Spatiotemporal transcriptomic divergence across human and macaque brain development
    Zhu, Ying; Sousa, André M. M.; Gao, Tianliuyun; Skarica, Mario; Li, Mingfeng; Santpere Baró, Gabriel, 1981-; Esteller-Cucala, Paula; Juan, David; Ferrández Peral, Luis, 1991-; Gulden, Forrest O.; Yang, Mo; Miller, Daniel J.; Marquès i Bonet, Tomàs, 1975-; Kawasawa, Yuka Imamura; Zhao, Hongyu; Sestan, Nenad (American Association for the Advancement of Science (AAAS), 2018)
    Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain ...
  • The population genomic legacy of the second plague pandemic
    Gopalakrishnan, Shyam; Juan, David; Gelabert Xirinachs, Pere, 1991-; Marquès i Bonet, Tomàs, 1975-; Lalueza Fox, Carles, 1965-; Gilbert, M Thomas (Elsevier, 2022)
    Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned ...
  • Transcriptome innovations in primates revealed by single-molecule long-read sequencing
    Ferrández Peral, Luis, 1991-; Zhan, Xiaoyu; Zhan, Xiaoyu; Alvarez-Estape, Marina; Chiva, Cristina; Esteller-Cucala, Paula; García Pérez, Raquel, 1989-; Julià, Eva; Lizano González, Esther, 1974-; Fornas Carreño, Oscar; Sabidó Aguadé, Eduard, 1981-; Li, Qiye; Marquès i Bonet, Tomàs, 1975-; Juan, David; Zhang, Guojie (Cold Spring Harbor Laboratory Press (CSHL Press), 2022)
    Transcriptomic diversity greatly contributes to the fundamentals of disease, lineage-specific biology, and environmental adaptation. However, much of the actual isoform repertoire contributing to shaping primate evolution ...
  • Variation in predicted COVID-19 risk among lemurs and lorises
    Melin, Amanda D.; Orkin, Joseph D.; Valenzuela, Alejandro; Gut, Ivo Glynne; Gut, Marta; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975-; Navarro i Cuartiellas, Arcadi, 1969-; Juan, David; Higham, James P. (Wiley, 2021)
    The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 2 million fatalities since it first emerged in late 2019. As we write, infection rates are at their ...