Browsing by Author "Juan, David"

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  • Zoonomia Consortium; Serres Armero, Aitor, 1992-; Juan, David; Kuderna, Lukas F.K.; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2020)
    The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe ...
  • Carrillo-de-Santa Pau, Enrique; Juan, David; Pancaldi, Vera; Were, Felipe; Martin-Subero, José Ignacio; Rico, Daniel; Valencia, Alfonso; BLUEPRINT Consortium (Oxford University Press, 2017)
    Hematopoiesis is one of the best characterized biological systems but the connection between chromatin changes and lineage differentiation is not yet well understood. We have developed a bioinformatic workflow to generate ...
  • Barteri, Fabio; Valenzuela, Alejandro; Farré, Xavier; Juan, David; Muntané, Gerard; Esteve Altava, Borja; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2023)
    Motivation: Coincidence of Convergent Amino Acid Substitutions (CAAS) with phenotypic convergences allow pinpointing genes and even individual mutations that are likely to be associated with trait variation within their ...
  • Wang, Yifan; Lobon, Irene; Juan, David; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975-; Abyzov, Alexej (BioMed Central, 2021)
    Background: Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. ...
  • Serres Armero, Aitor, 1992-; Davis, Brian W.; Povolotskaya, Inna, 1986-; Morcillo Suárez, Carlos, 1969-; Plassais, Jocelyn; Juan, David; Ostrander, Elaine A.; Marquès i Bonet, Tomàs, 1975- (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    Extreme phenotypic diversity, a history of artificial selection, and socioeconomic value make domestic dog breeds a compelling subject for genomic research. Copy number variation (CNV) is known to account for a significant ...
  • García Pérez, Raquel, 1989-; Esteller Cucala, Paula; Mas, Glòria; Lobón, Irene; Di Carlo, Valerio; Riera, Meritxell; Kuhlwilm, Martin; Navarro i Cuartiellas, Arcadi, 1969-; Blancher, Antoine; Di Croce, Luciano; Gómez Skarmeta, José Luis; Juan, David; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2021)
    Changes in the epigenetic regulation of gene expression have a central role in evolution. Here, we extensively profiled a panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ...
  • Telford, Marco, 1984-; Hughes, David; Juan, David; Stoneking, Mark; Navarro i Cuartiellas, Arcadi, 1969-; Santpere Baró, Gabriel, 1981- (MDPI, 2020)
    The Epstein-Barr Virus (EBV) infects the vast majority of human individuals worldwide (~90%) and is associated with several diseases, including different types of cancer and multiple sclerosis, which show wide variation ...
  • Kuderna, Lukas F.K.; Lizano González, Esther, 1974-; Julià, Eva; Gómez Garrido, Jèssica; Serres Armero, Aitor, 1992-; Kuhlwilm, Martin; Alandes, Regina Antoni; Alvarez-Estape, Marina; Juan, David; Simon, Heath; Alioto, Tyler; Gut, Marta; Gut, Ivo Glynne; Schierup, Mikkel H.; Fornas Carreño, Oscar; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2019)
    Mammalian Y chromosomes are often neglected from genomic analysis. Due to their inherent assembly difficulties, high repeat content, and large ampliconic regions, only a handful of species have their Y chromosome properly ...
  • Lobon, Irene; Solís Moruno, Manuel, 1993-; Juan, David; Muhaisen, Ashraf; Abascal, Federico; Esteller Cucala, Paula; García Pérez, Raquel, 1989-; Martí, Maria Josep; Tolosa, Eduard; Ávila, Jesús; Rahbari, Raheleh; Marquès i Bonet, Tomàs, 1975-; Casals López, Ferran; Soriano, Eduardo (Frontiers, 2022)
    The role of somatic mutations in complex diseases, including neurodevelopmental and neurodegenerative disorders, is becoming increasingly clear. However, to date, no study has shown their relation to Parkinson disease's ...
  • Zhu, Ying; Sousa, André M. M.; Gao, Tianliuyun; Skarica, Mario; Li, Mingfeng; Santpere Baró, Gabriel, 1981-; Esteller Cucala, Paula; Juan, David; Ferrández Peral, Luis, 1991-; Gulden, Forrest O.; Yang, Mo; Miller, Daniel J.; Marquès i Bonet, Tomàs, 1975-; Kawasawa, Yuka Imamura; Zhao, Hongyu; Sestan, Nenad (American Association for the Advancement of Science (AAAS), 2018)
    Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain ...
  • Gopalakrishnan, Shyam; Juan, David; Gelabert Xirinachs, Pere, 1991-; Marquès i Bonet, Tomàs, 1975-; Lalueza Fox, Carles, 1965-; Gilbert, M Thomas (Elsevier, 2022)
    Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned ...
  • Ferrández Peral, Luis, 1991-; Zhan, Xiaoyu; Zhan, Xiaoyu; Alvarez-Estape, Marina; Chiva, Cristina; Esteller Cucala, Paula; García Pérez, Raquel, 1989-; Julià, Eva; Lizano González, Esther, 1974-; Fornas Carreño, Oscar; Sabidó Aguadé, Eduard, 1981-; Li, Qiye; Marquès i Bonet, Tomàs, 1975-; Juan, David; Zhang, Guojie (Cold Spring Harbor Laboratory Press (CSHL Press), 2022)
    Transcriptomic diversity greatly contributes to the fundamentals of disease, lineage-specific biology, and environmental adaptation. However, much of the actual isoform repertoire contributing to shaping primate evolution ...
  • Melin, Amanda D.; Orkin, Joseph D.; Valenzuela, Alejandro; Gut, Ivo Glynne; Gut, Marta; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975-; Navarro i Cuartiellas, Arcadi, 1969-; Juan, David; Higham, James P. (Wiley, 2021)
    The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 2 million fatalities since it first emerged in late 2019. As we write, infection rates are at their ...
  • Esteller Cucala, Paula; Palmada Flores, Marc; Kuderna, Lukas F.K.; Fontseré Alemany, Clàudia, 1992-; Serres Armero, Aitor, 1992-; Dabad, Marc; Torralvo, María; Faella, Armida; Ferrández Peral, Luis, 1991-; Llovera Nadal, Laia; Fornas Carreño, Oscar; Julià, Eva; Ramírez, Erika; González, Irene; Hecht, Jochen; Lizano González, Esther, 1974-; Juan, David; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2023)
    Recent advances in long-read sequencing technologies have allowed the generation and curation of more complete genome assemblies, enabling the analysis of traditionally neglected chromosomes, such as the human Y chromosome ...

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