Browsing by Author "Jover, Rodrigo"

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  • Picó, María Dolores; Alvarez-Urturi, Ana Cristina; Jover, Rodrigo (Elsevier, 2020)
    Background & aims: Lynch syndrome is characterized by DNA mismatch repair (MMR) deficiency. Some patients with suspected Lynch syndrome have DNA MMR deficiencies but no detectable mutations in genes that encode MMR ...
  • Murcia, Oscar; Juárez, Míriam; Rodríguez-Soler, María; Hernández-Illán, Eva; Giner-Calabuig, Mar; Alustiza, Miren; Egoavil, Cecilia; Castillejo, Adela; Alenda, Cristina; Barbera, Victor Manuel; Mangas-Sanjuan, Carolina; Yuste, Ana; Bujanda, Luis; Clofent, Juan; Andreu García, Montserrat; Castells, Antoni; Llor, Xavier; Zapater, Pedro; Jover, Rodrigo (Public Library of Science (PLoS), 2018)
    OBJECTIVE: The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate ...
  • Carot, Laura; Castells, Antoni; Hernández Rodríguez, Cristina; Alvarez-Urturi, Ana Cristina; Balaguer, Francesc; Lanas, Angel; Cubiella, Joaquı́n; Tasende, Jose D.; Jover, Rodrigo; Hernandez, Vicent; Carballo, Fernando; Bujanda, Luis; Quintero, Enrique; Andreu García, Montserrat; Bessa Caserras, Xavier; ColonPrev study (SAGE Publications, 2018)
    BACKGROUND: The diagnostic yield of the faecal immunochemical test and sigmoidoscopy in detecting proximal serrated polyps in a colorectal cancer screening programme has not been fully assessed. AIM: We determined the ...
  • Hamaya, Yasushi; Guarinos, Carla; Tseng-Rogenski, Stephanie S.; Iwaizumi, Moriya; Das, Ritabrata; Jover, Rodrigo; Castells, Antoni; Llor, Xavier; Andreu García, Montserrat; Carethers, John M. (Public Library of Science, 2015)
    Elevated Microsatellite Alterations at Selected Tetranucleotide repeats (EMAST) is a genetic signature found in up to 60% of colorectal cancers (CRCs) that is caused by somatic dysfunction of the DNA mismatch repair (MMR) ...
  • Castillejo, Adela; Guarinos, Carla; Martínez Canto, Ana; Barbera, Victor Manuel; Egoavil, Cecilia; Castillejo, Maria Isabel; Pérez Carbonell, Lucía; Sánchez Heras, Ana Beatriz; Segura, Ángel; Ochoa, Enrique; Lazaro, Rafael; Ruiz Ponte, Clara; Bujanda, Luis; Andreu García, Montserrat; Castells, Antoni; Carracedo, Ángel; Llor, Xavier; Clofent, Juan; Alenda, Cristina; Paya, Artemio; Jover, Rodrigo; Soto, José Luis (BioMed Central, 2011)
    Background: Lynch syndrome (LS) is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS ...
  • Fernández-Rozadilla, C.; Álvarez-Barona, M.; Quintana, I.; López-Novo, A.; Amigo, J.; Cameselle-Teijeiro, J.M.; Roman, E.; Gonzalez, D.; Llor, Xavier; Llor, Xavier; Bujanda, Luis; Bessa Caserras, Xavier; Jover, Rodrigo; Balaguer, Francesc; Castells, Antoni; Castellví Bel, Sergi; Capellá, Gabriel; Carracedo, Ángel; Valle, L.; Ruiz Ponte, Clara (Nature Research, 2021)
    Colorectal cancer (CRC) is a complex disease that can be caused by a spectrum of genetic variants ranging from low to high penetrance changes, that interact with the environment to determine which individuals will develop ...
  • Kandimalla, K.; Linnekamp, J.F.; Van Hooff, S.; Castells, Antoni; Llor, Xavier; Andreu García, Montserrat; Jover, Rodrigo; Goel, A.; Medema, J.P. (Nature Publishing Group, 2017)
    Stage II colon cancer (CC) still remains a clinical challenge with patient stratification for adjuvant therapy (AT) largely relying on clinical parameters. Prognostic biomarkers are urgently needed for better stratification. ...
  • Pablo Fontecha, Verónica; Hernández-Illán, Eva; Reparaz, Andrea; Asensio Juan, Elena; Morata, Jordi; Tonda, Raúl; Lahoz, Sara; Parra, Carolina; Lozano, Juan José; García-Heredia, Anabel; Martínez-Roca, Alejandro; Beltran, Sergi; Balaguer, Francesc; Jover, Rodrigo; Castells, Antoni; Trullàs, Ramón; Podlesniy, Petar; Camps-Puchadas, Jordi (Nature Research, 2023)
    Somatic single-nucleotide variants (SNVs) occur every time a cell divides, appearing even in healthy tissues at low frequencies. These mutations may accumulate as neutral variants during aging, or eventually, promote the ...
  • Picó, María Dolores; Alvarez-Urturi, Ana Cristina; Jover, Rodrigo (MDPI, 2020)
    Lynch syndrome (LS) is a common cause of hereditary colorectal cancer (CRC). Some CRC patients develop mismatch repair deficiency without germline pathogenic mutation, known as Lynch-like syndrome (LLS). We compared the ...
  • Bustos, Aurelia; Payá, Artemio; Torrubia, Andrés; Jover, Rodrigo; Llor, Xavier; Bessa Caserras, Xavier; Castells, Antoni; Carracedo, Ángel; Alenda, Cristina (MDPI, 2021)
    The prediction of microsatellite instability (MSI) using deep learning (DL) techniques could have significant benefits, including reducing cost and increasing MSI testing of colorectal cancer (CRC) patients. Nonetheless, ...

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