Browsing by Author "John, Gregory St"

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  • Differential binding of sarilumab and tocilizumab to IL-6Rα and effects of receptor occupancy on clinical parameters
    Xu, Christine; Rafique, Ashique; Potocky, Terra; Paccaly, Anne; Nolain, Patrick; Lu, Qiang; Iglesias-Rodriguez, Melitza; John, Gregory St; Nivens, Michael C.; Kanamaluru, Vanaja; Fairhurst, Jeanette; Ishii, Tomonori; Maldonado, Rafael, 1961-; Choy, Ernest; Emery, Paul (Wiley, 2020)
    We evaluated interleukin-6 (IL-6) receptor-α subunit (IL-6Rα) signaling inhibition with sarilumab and tocilizumab, the association between IL-6Rα receptor occupancy (RO) and C-reactive protein (CRP), and the potential ...