Browsing by Author "Jiménez Conde, Jordi"

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  • Cárcel-Márquez, Jara; Jiménez Conde, Jordi; Roquer, Jaume; Fernández-Cadenas, Israel (Frontiers, 2022)
    Background: occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of ...
  • Cullell, Natalia; Soriano Tarraga, Carolina; Gallego-Fabrega, Cristina; Cárcel-Márquez, Jara; Muiño, Elena; Llucià-Carol, Laia; Lledós, Miquel; Esteller, Manel; Castro de Moura, Manuel; Montaner, Joan; Rosell, Anna; Delgado, Pilar; Martí-Fàbregas, Joan; Krupinski, Jerzy; Roquer, Jaume; Jiménez Conde, Jordi; Fernández-Cadenas, Israel (BioMed Central, 2022)
    Background and purpose: the neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play ...
  • Marini, Sandro; Roquer, Jaume; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Elosua Llanos, Roberto; Cuadrado-Godia, Elisa; Soriano Tarraga, Carolina; Anderson, Christopher D.; International Stroke Genetics Consortium (American Medical Association, 2019)
    Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic ...
  • Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Mola Caminal, Marina; Ois Santiago, Angel Javier; Rodríguez-Campello, Ana; Cuadrado-Godia, Elisa; Fernández-Cadenas, Israel; Cullell, Natalia; Roquer, Jaume; Jiménez Conde, Jordi (Nature Research, 2018)
    Age and stroke severity are the main mortality predictors after ischemic stroke. However, chronological age and biological age are not exactly concordant. Age-related changes in DNA methylation in multiple CpG sites across ...
  • Aigner, Johanna, 1981-; Villatoro, Sergi; Rabionet, Raquel; Roquer, Jaume; Jiménez Conde, Jordi; Martí, Eulàlia; Estivill, Xavier, 1955- (BioMed Central, 2013)
    Background: The Butyrophilin-like (BTNL) proteins are likely to play an important role in inflammation and immune response. Like the B7 protein family, many human and murine BTNL members have been shown to control T ...
  • Rannikmäe, K.; Sudlow, Cathie LM.; Metastroke Consortium; Jiménez Conde, Jordi; Metastroke Consortium; CHARGE WMH Group; ISGC ICH GWAS Study Collaboration; WMH in Ischemic Stroke GWAS Study Collaboration; International Stroke Genetics Consortium (Lippincott, Williams & Wilkins, 2015)
    OBJECTIVES: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. METHODS: We conducted meta-analyses of existing genotype data among ...
  • Jaworek, Thomas; Jiménez Conde, Jordi; Early Onset Stroke Genetics Consortium of the International Stroke Genetics Consortium (ISGC) (Wolters Kluwer (LWW), 2022)
    Background and objectives: Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic ...
  • Bonkhoff, Anna K.; Jiménez Conde, Jordi; Roquer, Jaume; Wasselius, Johan (Frontiers, 2022)
    Background purpose: a substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort. Materials and ...
  • Frid, Petrea; Giralt-Steinhauer, Eva; Roquer, Jaume; Jiménez Conde, Jordi; Stroke Genetics Network (SiGN); The International Stroke Genetics Consortium (ISGC); MRI-Genetics Interface Exploration (MRI-GENIE) Study (SpringerOpen, 2020)
    Objective: Posterior circulation ischemic stroke (PCiS) constitutes 20-30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. Such ...
  • Drake, Mattias; Giralt-Steinhauer, Eva; Roquer, Jaume; Jiménez Conde, Jordi; Wassélius, Johan (Frontiers, 2020)
    Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking ...
  • Gallego-Fabrega, Cristina; Cullell, Natalia; Soriano Tarraga, Carolina; Carrera, Caty; Torres-Aguila, Nuria P.; Muiño, Elena; Cárcel-Márquez, Jara; Castro de Moura, Manuel; Fernández Sanlés, Alba, 1988-; Esteller, Manel; Elosua Llanos, Roberto; Jiménez Conde, Jordi; Roquer, Jaume; Montaner, Joan; Krupinski, Jerzy; Fernández-Cadenas, Israel (Impact Journals, 2020)
    Background and purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while ...
  • Becerra Bachino, Virginia, 1975-; Ávila Pacheco, Mónica Marcela, 1984-; Jiménez Conde, Jordi; Cortes-Sanabria, Laura; Pardo Cladellas, Yolanda; Garin Boronat, Olatz, 1979-; Pont Acuña, Àngels; Alonso Caballero, Jordi; Cots Reguant, Francesc; Ferrer Forés, Maria Montserrat; Multicentric Spanish Group of Clinically Localized Prostate Cancer (BioMed Central, 2016)
    Background: Our objective was to assess the efficiency of treatments in patients with localized prostate cancer, by synthesizing available evidence from European economic evaluations through systematic review. Methods: ...
  • Jiménez-Balado, Joan; Giralt-Steinhauer, Eva; Fernández-Pérez, Isabel; Rey, Lucía; Cuadrado-Godia, Elisa; Ois, Ángel; Rodríguez-Campello, Ana; Soriano Tarraga, Carolina; Lazcano, Uxue; Macias-Gómez, Adrià; Suárez-Pérez, Antoni; Revert, Anna; Estragués-Gázquez, Isabel; Beltrán Mármol, Marlyn Briggith; Medrano-Martorell, Santiago; Capellades, Jaume; Roquer, Jaume; Jiménez Conde, Jordi (MDPI, 2023)
    In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both ...
  • Hong, Sungmin; Jiménez Conde, Jordi; Roquer, Jaume; Rost, Natalia; MRI-GENIE and GISCOME Investigators; International Stroke Genetics Consortium (Frontiers, 2021)
    Objective: To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden ...
  • Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Tajes Orduña, Marta; Valls Comamala, Victòria, 1987-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Gil Gómez, Gabriel; Alameda Quitllet, Francisco; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Elsevier, 2015)
    Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide ...
  • Chauhan, Ganesh; Jiménez Conde, Jordi; Debette, Stéphanie (Lippincott Williams & Wilkins, 2019)
    OBJECTIVE: To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. METHODS: We performed meta-analyses of genome-wide association studies (GWAS) and examined ...
  • Traylor, Matthew; Jiménez Conde, Jordi; International Stroke Genetics Consortium (Elsevier, 2021)
    Background: The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. Methods: ...
  • Giralt-Steinhauer, Eva; Jiménez-Balado, Joan; Fernández-Pérez, Isabel; Rey Álvarez, Lucía; Rodríguez-Campello, Ana; Ois Santiago, Angel Javier; Cuadrado-Godia, Elisa; Jiménez Conde, Jordi; Roquer, Jaume (MDPI, 2022)
    Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually ...
  • Söderholm, Martin; Fernández-Cadenas, Israel; Jiménez Conde, Jordi; Jern, Christina; International Stroke Genetics Consortium; Genetics of Ischaemic Stroke Functional Outcome (GISCOME) Network (Wolters Kluwer (LWW), 2019)
    Objective: To discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. Methods: The study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, ...
  • Cullell, Natalia; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Krupinski, Jerzy (Nature Research, 2020)
    Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms ...

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