Browsing by Author "Islam, Abul, 1978-"

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  • Hernando, Henar; Shannon Lowe, Claire; Islam, Abul, 1978-; Al-Shahrour, Fátima; Rodríguez Ubreva, Javier; Rodríguez Cortez, Virginia C; Javierre, Biola M.; Mangas, Cristina; Fernández, Agustín F.; Parra, Maribel; Delecluse, Henri Jacques; Esteller, Manel; López Granados, Eduardo; Fraga, Mario F.; López Bigas, Núria; Ballestar, Esteban (BioMed Central, 2013)
    Background: Epstein-Barr virus (EBV) infection is a well characterized etiopathogenic factor for a variety of immune-related conditions, including lymphomas, lymphoproliferative disorders and autoimmune diseases. EBV-mediated ...
  • Barneda Zahonero, Bruna; Román González, Lidia; Collazo, Olga; Rafati, Haleh; Islam, Abul, 1978-; Bussmann, Lars; Di Tullio, Alessandro, 1982-; Andrés, Luisa De; Graf, T. (Thomas); López Bigas, Núria; Mahmoudi, Tokameh; Parra, Maribel (Universitat Pompeu Fabra, 2013-05)
    HDAC7 is a repressor of myeloid genes whose downregulation in pre-B cells is required for transdifferentiation into macrophages.
  • Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Segalés Dalmau, Jessica; Islam, Abul, 1978-; Kumar, Roshan; Liu, Qi-Cai; Sousa-Victor, Pedro; Dilworth, F. Jeffrey; Ballestar, Esteban; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Background: Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although ...
  • Vona, Chiara Di; Bezdan, Daniela; Islam, Abul, 1978-; Salichs Fradera, Eulàlia; López Bigas, Núria; Ossowski, Stephan; Luna, Susana de la (Elsevier, 2015)
    DYRK1A is a dosage-sensitive protein kinase that fulfills key roles during development and in tissue homeostasis, and its dysregulation results in human pathologies. DYRK1A is present in both the nucleus and cytoplasm of ...
  • Islam, Abul, 1978-; Richter, William F.; Jacobs, Laura A.; López Bigas, Núria; Benevolenskaya, Elizaveta V. (Public Library of Science (PLoS), 2011)
    Cancer is characterized by aberrant patterns of expression of multiple genes. These major shifts in gene expression are believed to be due to not only genetic but also epigenetic changes. The epigenetic changes are ...
  • Nicolay, Brandon N.; Bayarmagnai, Battuya; Islam, Abul, 1978-; López Bigas, Núria; Frolov, Maxim V. (Cold Spring Harbor Laboratory Press (CSHL Press), 2011)
    The Hippo signaling pathway regulates organ size homeostasis, while its inactivation leads to severe hyperplasia in flies and mammals. The transcriptional coactivator Yorkie (Yki) mediates transcriptional output of the ...
  • Islam, Abul, 1978- (Universitat Pompeu Fabra, 2012-06-25)
    Recent advances in high throughput technology have opened the door to systematic studies of epigenetic mechanisms. One of the key components in the regulation of the cell cycle and differentiation is the retinoblastoma ...
  • Beshiri, Michael L.; Islam, Abul, 1978-; DeWaal, Dannielle C.; Richter, William F.; Love, Jennifer; López Bigas, Núria; Benevolenskaya, Elizaveta V. (MYJoVE Corporation, 2010)
    Recruitment of transcriptional and epigenetic factors to their targets is a key step in their regulation. Prominently featured in recruitment are the protein domains that bind to specific histone modifications. One such ...
  • Barneda Zahonero, Bruna; Román González, Lidia; Collazo, Olga; Rafati, Haleh; Islam, Abul, 1978-; Bussmann, Lars; Di Tullio, Alessandro, 1982-; Andrés, Luisa De; Graf, T. (Thomas); López Bigas, Núria; Mahmoudi, Tokameh; Parra, Maribel (Public Library of Science (PLoS), 2013)
    B lymphopoiesis is the result of several cell-commitment, lineage-choice, and differentiation processes. Every differentiation step is characterized by the activation of a new, lineage-specific, genetic program and the ...
  • Islam, Abul, 1978-; Guiu Sagarra, Jordi, 1983-; Bergen, Dylan J.M.; de Pater, Emma; Ayllon, Verónica; Gama-Norton, Leonor; Ruiz Herguido, Cristina; González, Jessica; López Bigas, Núria; Menéndez, Pablo; Dzierzak, Elaine; Espinosa Blay, Lluís; Bigas Salvans, Anna (Rockefeller University Press, 2014)
    Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements controlling de novo HSC generation are still unknown. Here, we identify ...
  • Váraljai, Renáta; Islam, Abul, 1978-; Beshiri, Michael L.; Rehman, Jalees; López Bigas, Núria; Benevolenskaya, Elizaveta V. (Cold Spring Harbor Laboratory Press (CSHL Press), 2015)
    The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also promotes differentiation, but the mechanisms are poorly understood, ...
  • Gundem, Gunes; Pérez Llamas, Christian, 1976-; Jené i Sanz, Alba, 1984-; Kedzierska, Anna; Islam, Abul, 1978-; Déu Pons, Jordi; Furney, Simon J.; López Bigas, Núria (Universitat Pompeu Fabra, 2010-02)
    Genes and pathways affected by expression and copy number changes in tumors across projects and cancer types.
  • Truscott, Mary; Islam, Abul, 1978-; Lightfoot, James; López Bigas, Núria; Frolov, Maxim V. (Public Library of Science (PLoS), 2014)
    The importance of microRNAs in the regulation of various aspects of biology and disease is well recognized. However, what remains largely unappreciated is that a significant number of miRNAs are embedded within and are ...
  • Ambrus, Aaron M.; Islam, Abul, 1978-; Holmes, Katherine B.; Moon, Nam Sung; López Bigas, Núria; Benevolenskaya, Elizaveta V.; Frolov, Maxim V. (Elsevier, 2013)
    E2F/DP transcription factors regulate cell proliferation and apoptosis. Here, we investigated the mechanism of the resistance of Drosophila dDP mutants to irradiation-induced apoptosis. Contrary to the prevailing view, ...
  • Millán Ariño, Lluís, 1984-; Islam, Abul, 1978-; Izquierdo Bouldstridge, Andrea; Mayor, Regina; Terme, Jean Michel; Luque, Neus; Sancho Medina, Mónica; López Bigas, Núria; Jordan, Albert (Oxford University Press, 2014)
    Seven linker histone H1 variants are present in human somatic cells with distinct prevalence across cell types. Despite being key structural components of chromatin, it is not known whether the different variants have ...
  • Truscott, Mary; Islam, Abul, 1978-; López Bigas, Núria; Frolov, Maxim V. (Cold Spring Harbor Laboratory Press (CSHL Press), 2011)
    The E2F family of transcription factors regulates the expression of both genes associated with cell proliferation and genes that regulate cell death. The net outcome is dependent on cellular context and tissue environment. ...
  • Gama-Norton, Leonor; Ferrando Martorell, Eva, 1986-; Ruiz Herguido, Cristina; Liu, Zenhy; Guiu Sagarra, Jordi, 1983-; Islam, Abul, 1978-; Lee, Sung-Uk; Yan, Minhong; Guidos, Cynthia J.; López Bigas, Núria; Maeda, Takahiro; Espinosa Blay, Lluís; Kopan, Raphael; Bigas Salvans, Anna (Nature Publishing Group, 2015)
    Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the ...
  • Perearnau, Anna; Orlando, Serena; Islam, Abul, 1978-; Gallastegui Calvache, Edurne; Martínez, Jonatan; Jordan, Albert; Bigas Salvans, Anna; Aligu, Rosa; Pujol, Maria Jesús; Bachs Valldeneu, Oriol (Oxford University Press, 2017)
    The cyclin-dependent kinase inhibitor p27Kip1 (p27) also behaves as a transcriptional repressor. Data showing that the p300/CBP-associated factor (PCAF) acetylates p27 inducing its degradation suggested that PCAF and p27 ...
  • Rica, Lorenzo de la; Rodríguez Ubreva, Javier; García, Mireia; Islam, Abul, 1978-; Urquiza, José M.; Hernando, Henar; Christensen, Jesper; Helin, Kristian; Gómez Vaquero, Carmen; Ballestar, Esteban (BioMed Central, 2013)
    Background: DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-fate decisions. Local deposition and removal of DNA methylation are tightly coupled with transcription factor binding, although the ...