Browsing by Author "Iglesias Coma, Mar"

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  • López De Maturana, Evangelina; Rodríguez, Juan Antonio; Lao Grueso, Oscar, 1976-; Iglesias Coma, Mar; Cecchini Rosell, Lluís; Ilzarbe Sánchez, Lucas; Real, Francisco X.; Malats i Riera, Núria (BioMed Central, 2021)
    Background: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% ...
  • Gomez-Rubio, P.; Piñero González, Janet, 1977-; Ilzarbe Sánchez, Lucas; Iglesias Coma, Mar; Poves Prim, José Ignacio; Real, Francisco X.; PanGenEU Study Investigators (Oxford University Press, 2017)
    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed in late adulthood; therefore, many patients suffer or have suffered from other diseases. Identifying disease patterns associated with PDAC risk may ...
  • Margalef González, Pol, 1985-; Fernández Majada, Vanessa; Villanueva, Alberto; Garcia Carbonell, Ricard; Iglesias Coma, Mar; López Muñoz, Laura; Martínez Iniesta, María; Villà i Freixa, Jordi; Mulero, María Carmen; Andreu García, Montserrat; Torres, Ferran; Mayo, Marty W.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2012)
    Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and IKKα activity remains ...
  • López Arribillaga, Erika, 1986-; Yan, Bing; Lobo-Jarne, Teresa; Guillén, Yolanda; Menéndez, Silvia; Andreu García, Montserrat; Bigas Salvans, Anna; Iglesias Coma, Mar; Espinosa Blay, Lluís (MDPI, 2021)
    Background: previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. ...
  • Lop Gros, Joan; Iglesias Coma, Mar; González-Farré, Mónica; Serra, Consol (Elsevier, 2020)
    Existe debate sobre si las alteraciones en el olfato deberían considerarse un síntoma de la COVID-19. Se realizó una revisión sistemática bibliográfica de los artículos indexados en PubMed sobre alteraciones del olfato en ...
  • López Arribillaga, Erika, 1986-; Rodilla, Verónica; Pellegrinet, Luca; Guiu Sagarra, Jordi, 1983-; Iglesias Coma, Mar; Roman, Angel Carlos; Gutarra, Susana; González, Susana; Muñoz Cánoves, Pura, 1962-; Fernández-Salguero, Pedro; Radtke, Freddy; Bigas Salvans, Anna; Espinosa Blay, Lluís (Company of Biologists, 2015)
    Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation ...
  • Margalef González, Pol, 1985-; Colomer Montañà, Carlota, 1990-; Villanueva, Alberto; Montagut Viladot, Clara; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Salazar, Ramón; Martínez Iniesta, María; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Association for the Advancement of Science, 2015)
    KRAS mutations contribute to cell proliferation and survival in numerous cancers, including colorectal cancers (CRC). One pathway through which mutant KRAS acts is an inflammatory pathway that involves the kinase IKK and ...
  • Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Gallardo Hernández, Fernando; Padrón, Andreina; Garcia Carbonell, Ricard; Rius, Cristina; González-Pérez, Abel; Arumí, Montserrat; Iglesias Coma, Mar; Nonell Mazelón, Lara; Bellosillo Paricio, Beatriz; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria; López Bigas, Núria; Bertran, Joan; Bigas Salvans, Anna; Espinosa Blay, Lluís (Impact Journal, 2015)
    Invasive malignant melanoma (MM) is an aggressive tumor with no curative therapy available in advanced stages. Nuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found ...
  • Molina Montes, Esther; Iglesias Coma, Mar; Ilzarbe Sánchez, Lucas; Poves Prim, José Ignacio; Real, Francisco X.; PanGenEU Study Investigators (BMJ Publishing Group, 2021)
    Objectives: To characterise the association between type 2 diabetes mellitus (T2DM) subtypes (new-onset T2DM (NODM) or long-standing T2DM (LSDM)) and pancreatic cancer (PC) risk, to explore the direction of causation through ...
  • Sampera Borràs, Aïda, 1990-; Sánchez-Martín, Francisco Javier; Arpí Llucià, Oriol; Visa Turmo, Laura; Iglesias Coma, Mar; Menéndez, Silvia; Gaye, Élisabeth; Dalmases Massegú, Alba, 1982-; Clavé Safont, Sergi; Gelabert-Baldrich, Mariona; Tuxen Poulsen, Thomas; Kragh, Michael; Bellosillo Paricio, Beatriz; Albanell Mestres, Joan; Rovira Guerín, Ana; Rovira Guerín, Ana; Montagut Viladot, Clara (American Association for Cancer Research (AACR), 2019)
    Despite the clinical benefit of trastuzumab, eventually all HER2-amplified gastric cancer tumors develop drug resistance. We aimed to identify molecular mechanisms of acquired resistance to trastuzumab in gastric cancer ...
  • Sánchez, Ariadna; Hernandez, Goretti; Iglesias Coma, Mar; Moreira, Leticia (MDPI, 2021)
    Background: Small bowel adenocarcinoma (SBA) is a rare disease which can be associated with Lynch syndrome (LS). LS tumors are characterized by the presence of microsatellite instability (MSI) and/or the loss of mismatch ...
  • López Millán, Belen; Menéndez, Silvia; Iglesias Coma, Mar; Menéndez, Pablo (Taylor & Francis, 2018)
    Treatment for acute myeloid leukemia (AML) remains suboptimal and many patients remain refractory or relapse upon standard chemotherapy based on nucleoside analogs plus anthracyclines. The crosstalk between AML cells and ...
  • Martínez Bosch, Neus; Barranco Priego, Luis Eugenio; Orozco, Carlos Alberto; Moreno, Mireia; Visa Turmo, Laura; Iglesias Coma, Mar; Oldfield, Lucy; Neoptolemos, John P.; Greenhalf, William; Earl, Julie; Carrato, Alfredo; Costello, Eithne; Navarro Medrano, Pilar (Impact Journal, 2018)
    Pancreatic ductal adenocarcinoma (PDA) is the most frequent type of pancreatic cancer and one of the deadliest diseases overall. New biomarkers are urgently needed to allow early diagnosis, one of the only factors that ...
  • Inglés Esteve, Julia; Morales, Mònica; Dalmases Massegú, Alba, 1982-; Garcia Carbonell, Ricard; Jené i Sanz, Alba, 1984-; López Bigas, Núria; Iglesias Coma, Mar; Ruiz Herguido, Cristina; Rovira Guerín, Ana; Rojo, Federico; Albanell Mestres, Joan; Gomis, Roger R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Public Library of Science (PLoS), 2012)
    14-3-3σ is frequently lost in human breast cancers by genetic deletion or promoter methylation. We have now investigated the involvement of 14-3-3σ in the termination of NF-κB signal in mammary cells and its putative role ...
  • Quesada Diez, Rita; Poves Prim, José Ignacio; Iglesias Coma, Mar; Berjano, Enrique J.; Grande Posa, Luís; Burdío Pinilla, Fernando (SpringerOpen, 2016)
    Background: Although radiofrequency-assisted devices have sometimes been used in partial splenectomy, this is not a common technique. This report describes the first case of laparoscopic partial splenectomy using an ...
  • Albero-González, Raquel; Gimeno Beltran, Javier; Vázquez‐de las Heras, Ivonne; Martínez-Orfila, Joan; Seoane-Urgorri, Agustín; Naranjo‐Hans, Dolores; Corominas Torres, Josep Maria; Iglesias Coma, Mar; Alameda Quitllet, Francisco (Elsevier, 2016)
    Lobular breast carcinoma involving the colon is a rare condition. In most cases reported in the literature, metastases are detected after a 20-year latency period after the initial diagnosis. Here we describe a case in ...
  • Ivorra Cano, Antoni, 1974-; Sánchez Velázquez, Patricia, 1985-; Castellví Fernández, Quim; Villanueva, Alberto; Iglesias Coma, Mar; Quesada Diez, Rita; Pañella Vilamú, Clara, 1987-; Cáceres Aguilar, Mario; Dorcaratto, Dimitri; Andaluz, Anna; Moll, Xavier; Burdío, José M.; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Publishing Group, 2017)
    Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with ...
  • López Arribillaga, Erika, 1986-; Rodilla, Verónica; Colomer Montañà, Carlota, 1990-; Vert, Anna; Shelton, Amy; Cheng, Jason H.; Yan, Bing; González Pérez, Abel; Junttila, Melissa R.; Iglesias Coma, Mar; Torres, Ferran; Albanell Mestres, Joan; Villanueva, Alberto; Bigas Salvans, Anna; Siebel, Christian W.; Espinosa Blay, Lluís (Nature Research, 2018)
    Delta ligands regulate Notch signaling in normal intestinal stem cells, while Jagged1 activates Notch in intestinal adenomas carrying active β-catenin. We used the ApcMin/+ mouse model, tumor spheroid cultures, and ...
  • Gasull Panadès, Magda; Pumarega Rodríguez, José Antonio; Iglesias Coma, Mar; Kühn, Tilman; Porta Serra, Miquel (Elsevier, 2019)
    BACKGROUND: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex ...