Browsing by Author "Iglesias Coma, Mar"

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  • Gomez-Rubio, P.; Piñero González, Janet, 1977-; Ilzarbe Sánchez, Lucas; Iglesias Coma, Mar; Poves Prim, José Ignacio; Real, Francisco X. (Oxford University Press, 2017)
    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed in late adulthood; therefore, many patients suffer or have suffered from other diseases. Identifying disease patterns associated with PDAC risk may ...
  • Margalef González, Pol, 1985-; Fernández Majada, Vanessa; Villanueva, Alberto; Garcia Carbonell, Ricard; Iglesias Coma, Mar; López Muñoz, Laura; Martínez Iniesta, María; Villà i Freixa, Jordi; Mulero, María Carmen; Andreu García, Montserrat; Torres, Ferran; Mayo, Marty W.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2012)
    Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and IKKα activity remains ...
  • López Arribillaga, Erika; Rodilla, Verónica; Pellegrinet, Luca; Guiu Sagarra, Jordi, 1983-; Iglesias Coma, Mar; Roman, Angel Carlos; Gutarra, Susana; González, Susana; Muñoz Cánoves, Pura, 1962-; Fernández-Salguero, Pedro; Radtke, Freddy; Bigas Salvans, Anna; Espinosa Blay, Lluís (Company of Biologists, 2015)
    Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation ...
  • Margalef González, Pol, 1985-; Colomer Montañá, Carlota; Villanueva, Alberto; Montagut Viladot, Clara; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Salazar, Ramón; Martínez Iniesta, María; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Association for the Advancement of Science, 2015)
    KRAS mutations contribute to cell proliferation and survival in numerous cancers, including colorectal cancers (CRC). One pathway through which mutant KRAS acts is an inflammatory pathway that involves the kinase IKK and ...
  • Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Gallardo Hernández, Fernando; Padrón, Andreina; Garcia Carbonell, Ricard; Rius, Cristina; González-Pérez, Abel; Arumí, Montserrat; Iglesias Coma, Mar; Nonell Mazelón, Lara; Bellosillo Paricio, Beatriz; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria; López Bigas, Núria; Bertran, Joan; Bigas Salvans, Anna; Espinosa Blay, Lluís (Impact Journal, 2015)
    Invasive malignant melanoma (MM) is an aggressive tumor with no curative therapy available in advanced stages. Nuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found ...
  • López Millán, Belen; Menéndez, Silvia; Iglesias Coma, Mar; Menéndez, Pablo (Taylor & Francis, 2018)
    Treatment for acute myeloid leukemia (AML) remains suboptimal and many patients remain refractory or relapse upon standard chemotherapy based on nucleoside analogs plus anthracyclines. The crosstalk between AML cells and ...
  • Martínez Bosch, Neus; Barranco Priego, Luis Eugenio; Orozco, Carlos Alberto; Moreno, Mireia; Visa Turmo, Laura; Iglesias Coma, Mar; Oldfield, Lucy; Neoptolemos, John P.; Greenhalf, William; Earl, Julie; Carrato, Alfredo; Costello, Eithne; Navarro Medrano, Pilar (Impact Journal, 2018)
    Pancreatic ductal adenocarcinoma (PDA) is the most frequent type of pancreatic cancer and one of the deadliest diseases overall. New biomarkers are urgently needed to allow early diagnosis, one of the only factors that ...
  • Inglés Esteve, Julia; Morales, Mònica; Dalmases Massegú, Alba, 1982-; Garcia Carbonell, Ricard; Jené i Sanz, Alba, 1984-; López Bigas, Núria; Iglesias Coma, Mar; Ruiz Herguido, Cristina; Rovira Guerín, Ana; Rojo, Federico; Albanell Mestres, Joan; Gomis, Roger R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Public Library of Science (PLoS), 2012)
    14-3-3σ is frequently lost in human breast cancers by genetic deletion or promoter methylation. We have now investigated the involvement of 14-3-3σ in the termination of NF-κB signal in mammary cells and its putative role ...
  • Quesada Diez, Rita; Poves Prim, José Ignacio; Iglesias Coma, Mar; Berjano, Enrique J.; Grande Posa, Luís; Burdío Pinilla, Fernando (SpringerOpen, 2016)
    Background: Although radiofrequency-assisted devices have sometimes been used in partial splenectomy, this is not a common technique. This report describes the first case of laparoscopic partial splenectomy using an ...
  • Albero-González, Raquel; Gimeno Beltran, Javier; Vázquez‐de las Heras, Ivonne; Martínez-Orfila, Joan; Seoane-Urgorri, Agustín; Naranjo‐Hans, Dolores; Corominas Torres, Josep Maria; Iglesias Coma, Mar; Alameda Quitllet, Francisco (Elsevier, 2016)
    Lobular breast carcinoma involving the colon is a rare condition. In most cases reported in the literature, metastases are detected after a 20-year latency period after the initial diagnosis. Here we describe a case in ...
  • Ivorra Cano, Antoni, 1974-; Sánchez Velázquez, Patricia, 1985-; Castellví Fernández, Quim; Villanueva, Alberto; Iglesias Coma, Mar; Quesada Diez, Rita; Pañella-Vilamú, Clara; Cáceres Aguilar, Mario; Dorcaratto, Dimitri; Andaluz, Anna; Moll, Xavier; Burdío, José Miguel; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Publishing Group, 2017)
    Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with ...
  • López Arribillaga, Erika; Rodilla, Verónica; Colomer Montañá, Carlota; Vert, Anna; Shelton, Amy; Cheng, Jason H.; Yan, Bing; González Pérez, Abel; Junttila, Melissa R.; Iglesias Coma, Mar; Torres, Ferran; Albanell Mestres, Joan; Villanueva, Alberto; Bigas Salvans, Anna; Siebel, Christian W.; Espinosa Blay, Lluís (Nature Research, 2018)
    Delta ligands regulate Notch signaling in normal intestinal stem cells, while Jagged1 activates Notch in intestinal adenomas carrying active β-catenin. We used the ApcMin/+ mouse model, tumor spheroid cultures, and ...
  • Gasull Panadès, Magda; Pumarega Rodríguez, José Antonio; Iglesias Coma, Mar; Kühn, Tilman; Porta Serra, Miquel (Elsevier, 2019)
    BACKGROUND: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex ...
  • Prieto, Cristina; Iglesias Coma, Mar; Menéndez, Pablo (Nature Publishing Group, 2018)
    Mixed-lineage leukemia (MLL)-rearranged (MLLr) infant B-cell acute lymphoblastic leukemia (iMLLr-B-ALL) has a dismal prognosis and is associated with a pro-B/mixed phenotype, therapy refractoriness and frequent central ...
  • Gallardo Hernández, Fernando; Bertran, Joan; López Arribillaga, Erika; González, Jessica; Menéndez, Silvia; Sánchez Güerri, Ignacio; Colomo Saperas, Luis Alberto; Iglesias Coma, Mar; Garrido, Marta; Santamaría-Babí, Luis Francisco; Torres, Ferran; Pujol Vallverdú, Ramon Maria; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Publishing Group, 2018)
  • Calon, Alexandre; Lonardo, Enza; Berenguer-Llergo, Antonio; Espinet, Elisa; Hernando-Momblona, Xavier; Iglesias Coma, Mar; Sevillano, Marta; Palomo-Ponce, Sergio; Tauriello, Daniele V.F.; Byrom, Daniel; Cortina Duran, Carme; Morral, Clara; Barceló, Carles; Tosi, Sebastien; Riera, Antoni; Attolini, Camille Stephan-Otto; Rossell, David; Sancho, Elena; Batlle Gómez, Eduard (Nature Publishing Group, 2015)
    Recent molecular classifications of colorectal cancer (CRC) based on global gene expression profiles have defined subtypes displaying resistance to therapy and poor prognosis. Upon evaluation of these classification systems, ...
  • Merlos-Suárez, Anna; Barriga de Vicente, Francisco Martín, 1983-; Jung, Peter; Iglesias Coma, Mar; Céspedes, María Virtudes; Rossell, David; Sevillano, Marta; Hernando-Momblona, Xavier; Silva-Diz, Victoria da; Muñoz, Purificación; Clevers, Hans; Sancho, Elena; Mangues, Ramon; Batlle Gómez, Eduard (Elsevier, 2011)
    A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients. ...