Browsing by Author "Iglesias Coma, Mar"

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  • A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
    López De Maturana, Evangelina; Rodríguez, Juan Antonio; Lao Grueso, Oscar, 1976-; Iglesias Coma, Mar; Cecchini Rosell, Lluís; Ilzarbe Sánchez, Lucas; Real, Francisco X.; Malats i Riera, Núria (BioMed Central, 2021)
    Background: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% ...
  • A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk
    Gomez-Rubio, P.; Piñero González, Janet, 1977-; Ilzarbe Sánchez, Lucas; Iglesias Coma, Mar; Poves Prim, José Ignacio; Real, Francisco X.; PanGenEU Study Investigators (Oxford University Press, 2017)
    BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed in late adulthood; therefore, many patients suffer or have suffered from other diseases. Identifying disease patterns associated with PDAC risk may ...
  • A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer
    Margalef González, Pol, 1985-; Fernández Majada, Vanessa; Villanueva, Alberto; Garcia Carbonell, Ricard; Iglesias Coma, Mar; López Muñoz, Laura; Martínez Iniesta, María; Villà i Freixa, Jordi; Mulero, María Carmen; Andreu García, Montserrat; Torres, Ferran; Mayo, Marty W.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2012)
    Nuclear IKKα regulates gene transcription by phosphorylating specific substrates and has been linked to cancer progression and metastasis. However, the mechanistic connection between tumorigenesis and IKKα activity remains ...
  • Accumulation of paneth cells in early colorectal adenomas is associated with beta-catenin signaling and poor patient prognosis
    López Arribillaga, Erika, 1986-; Yan, Bing; Lobo-Jarne, Teresa; Guillén, Yolanda; Menéndez, Silvia; Andreu García, Montserrat; Bigas Salvans, Anna; Iglesias Coma, Mar; Espinosa Blay, Lluís (MDPI, 2021)
    Background: previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. ...
  • Alteraciones del olfato en la COVID-19, revisión de la evidencia e implicaciones en el manejo de la pandèmia
    Lop Gros, Joan; Iglesias Coma, Mar; González-Farré, Mónica; Serra, Consol (Elsevier, 2020)
    Existe debate sobre si las alteraciones en el olfato deberían considerarse un síntoma de la COVID-19. Se realizó una revisión sistemática bibliográfica de los artículos indexados en PubMed sobre alteraciones del olfato en ...
  • Atypical double colorectal metastasis: spleen and uterus
    Morera-Grau, Álex; Patriarca-Amiano, María Evangelina; Santiago-Díaz, Pablo; Serrano-Munné, Laia; Ielpo, Benedetto; Burdío Pinilla, Fernando; Pera-Román, Miguel; Espuelas Malón, Silvia; Iglesias Coma, Mar; Sánchez Velázquez, Patricia, 1985- (Oxford University Press, 2022)
    Oligometastatic disease is a relatively new concept that refers to an intermediate stage between disseminated and localized cancer. Most frequent locations for colorectal metastasis are lung and liver. We present an a ...
  • Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch
    López Arribillaga, Erika, 1986-; Rodilla, Verónica; Pellegrinet, Luca; Guiu Sagarra, Jordi, 1983-; Iglesias Coma, Mar; Roman, Angel Carlos; Gutarra, Susana; González, Susana; Muñoz Cánoves, Pura, 1962-; Fernández-Salguero, Pedro; Radtke, Freddy; Bigas Salvans, Anna; Espinosa Blay, Lluís (Company of Biologists, 2015)
    Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation ...
  • BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent
    Margalef González, Pol, 1985-; Colomer Montañà, Carlota, 1990-; Villanueva, Alberto; Montagut Viladot, Clara; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Salazar, Ramón; Martínez Iniesta, María; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Association for the Advancement of Science, 2015)
    KRAS mutations contribute to cell proliferation and survival in numerous cancers, including colorectal cancers (CRC). One pathway through which mutant KRAS acts is an inflammatory pathway that involves the kinase IKK and ...
  • Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer
    Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2013)
    IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of ...
  • Clinical features of gastric signet ring cell cancer: results from a systematic review and meta-analysis
    Dal Cero, Mariagiulia; Bencivenga, Maria; Liu, Drolaiz H. W.; Sacco, Michele; Alloggio, Mariella; Kerckhoffs, Kelly G. P.; Filippini, Federica; Saragoni, Luca; Iglesias Coma, Mar; Tomezzoli, Anna; Carneiro, Fátima; Grabsch, Heike I.; Verlato, Giuseppe; Torroni, Lorena; Piessen, Guillaume; Pera Roman, Manuel Ramón; De Manzoni, Giovanni (MDPI, 2023)
    Background: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis ...
  • Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance
    Gallardo Hernández, Fernando; Padrón, Andreina; Garcia Carbonell, Ricard; Rius, Cristina; González-Pérez, Abel; Arumí, Montserrat; Iglesias Coma, Mar; Nonell Mazelon, Lara, 1972-; Bellosillo Paricio, Beatriz; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria; López Bigas, Núria; Bertran, Joan; Bigas Salvans, Anna; Espinosa Blay, Lluís (Impact Journal, 2015)
    Invasive malignant melanoma (MM) is an aggressive tumor with no curative therapy available in advanced stages. Nuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found ...
  • Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses
    Molina Montes, Esther; Iglesias Coma, Mar; Ilzarbe Sánchez, Lucas; Poves Prim, José Ignacio; Real, Francisco X.; PanGenEU Study Investigators (BMJ Publishing Group, 2021)
    Objectives: To characterise the association between type 2 diabetes mellitus (T2DM) subtypes (new-onset T2DM (NODM) or long-standing T2DM (LSDM)) and pancreatic cancer (PC) risk, to explore the direction of causation through ...
  • HER-family ligands promote acquired resistance to trastuzumab in gastric cancer
    Sampera Borràs, Aïda, 1990-; Sánchez-Martín, Francisco Javier; Arpí Llucià, Oriol; Visa Turmo, Laura; Iglesias Coma, Mar; Menéndez, Silvia; Gaye, Élisabeth; Dalmases Massegú, Alba, 1982-; Clavé Safont, Sergi; Gelabert-Baldrich, Mariona; Tuxen Poulsen, Thomas; Kragh, Michael; Bellosillo Paricio, Beatriz; Albanell Mestres, Joan; Rovira Guerín, Ana; Rovira Guerín, Ana; Montagut Viladot, Clara (American Association for Cancer Research (AACR), 2019)
    Despite the clinical benefit of trastuzumab, eventually all HER2-amplified gastric cancer tumors develop drug resistance. We aimed to identify molecular mechanisms of acquired resistance to trastuzumab in gastric cancer ...
  • Identification of Lynch syndrome carriers among patients with small bowel adenocarcinoma
    Sánchez, Ariadna; Hernandez, Goretti; Iglesias Coma, Mar; Moreira, Leticia (MDPI, 2021)
    Background: Small bowel adenocarcinoma (SBA) is a rare disease which can be associated with Lynch syndrome (LS). LS tumors are characterized by the presence of microsatellite instability (MSI) and/or the loss of mismatch ...
  • IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q-AML
    López Millán, Belen; Menéndez, Silvia; Iglesias Coma, Mar; Menéndez, Pablo (Taylor & Francis, 2018)
    Treatment for acute myeloid leukemia (AML) remains suboptimal and many patients remain refractory or relapse upon standard chemotherapy based on nucleoside analogs plus anthracyclines. The crosstalk between AML cells and ...
  • Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker
    Martínez Bosch, Neus; Barranco Priego, Luis Eugenio; Orozco, Carlos Alberto; Moreno, Mireia; Visa Turmo, Laura; Iglesias Coma, Mar; Oldfield, Lucy; Neoptolemos, John; Greenhalf, William; Earl, Julie; Carrato, Alfredo; Costello, Eithne; Navarro Medrano, Pilar (Impact Journal, 2018)
    Pancreatic ductal adenocarcinoma (PDA) is the most frequent type of pancreatic cancer and one of the deadliest diseases overall. New biomarkers are urgently needed to allow early diagnosis, one of the only factors that ...
  • Inhibition of specific NF-KB activity contributes to the tumor suppressor function of 14-3-3omega in breast cancer
    Inglés Esteve, Julia; Morales, Mònica; Dalmases Massegú, Alba, 1982-; Garcia Carbonell, Ricard; Jené i Sanz, Alba, 1984-; López Bigas, Núria; Iglesias Coma, Mar; Ruiz Herguido, Cristina; Rovira Guerín, Ana; Rojo, Federico; Albanell Mestres, Joan; Gomis, Roger R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Public Library of Science (PLoS), 2012)
    14-3-3σ is frequently lost in human breast cancers by genetic deletion or promoter methylation. We have now investigated the involvement of 14-3-3σ in the termination of NF-κB signal in mammary cells and its putative role ...
  • Laparoscopic partial splenectomy for giant cyst using a radiofrequency-assisted device: a case report
    Quesada Diez, Rita; Poves Prim, José Ignacio; Iglesias Coma, Mar; Berjano, Enrique J.; Grande Posa, Luís; Burdío Pinilla, Fernando (SpringerOpen, 2016)
    Background: Although radiofrequency-assisted devices have sometimes been used in partial splenectomy, this is not a common technique. This report describes the first case of laparoscopic partial splenectomy using an ...
  • Lobular breast carcinoma with colonic metastases: A synchronous diagnosis in a 4-day period
    Albero-González, Raquel; Gimeno Beltran, Javier; Vázquez‐de las Heras, Ivonne; Martínez-Orfila, Joan; Seoane-Urgorri, Agustín; Naranjo‐Hans, Dolores; Corominas Torres, Josep Maria; Iglesias Coma, Mar; Alameda Quitllet, Francisco (Elsevier, 2016)
    Lobular breast carcinoma involving the colon is a rare condition. In most cases reported in the literature, metastases are detected after a 20-year latency period after the initial diagnosis. Here we describe a case in ...
  • Long-term effectiveness of irreversible electroporation in a murine model of colorectal liver metastasis
    Ivorra Cano, Antoni, 1974-; Sánchez Velázquez, Patricia, 1985-; Castellví Fernández, Quim; Villanueva, Alberto; Iglesias Coma, Mar; Quesada Diez, Rita; Pañella Vilamú, Clara, 1987-; Cáceres Aguilar, Mario; Dorcaratto, Dimitri; Andaluz, Anna; Moll, Xavier; Burdío, José M.; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Publishing Group, 2017)
    Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with ...

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