Browsing by Author "Hummel, Manuela"

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  • Cyclic AMP signaling restricts activation and promotes maturation and antioxidant defenses in astrocytes
    Paco, Sonia; Hummel, Manuela; Plá, Virginia; Sumoy Van Dyck, Lauro; Aguado, Fernando (BioMed Central, 2016)
    BACKGROUND: cAMP signaling produces dramatic changes in astrocyte morphology and physiology. However, its involvement in phenotype acquisition and the transcriptionally mediated mechanisms of action are largely unknown. ...
  • Gene expression changes in blood RNA after swimming in a chlorinated pool
    Salas, Lucas A.; Font Ribera, Laia; Bustamante Pineda, Mariona; Sumoy Van Dyck, Lauro; Grimalt Obrador, Joan; Bonnin, Sarah; Aguilar Morón, María Asunción; Mattlin, Heidi; Hummel, Manuela; Ferrer Del Alamo, Ana; Kogevinas, Manolis; Villanueva Belmonte, Cristina (Elsevier, 2017)
    Exposure to disinfection by-products (DBP) such as trihalomethanes (THM) in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes ...
  • Microarray and deep sequencing cross-platform analysis of the mirRNome and isomiR variation in response to epidermal growth factor
    Llorens, Franc; Hummel, Manuela; Pantano Rubiño, Lorena, 1982-; Pastor, Xavier; Vivancos Prellezo, Ana; Castillo Andreo, Esther; Mattlin, Heidi; Ferrer Admetlla, Anna; Ingham, Matthew; Noguera, Marc; Kofler, Robert; Dohm, Juliane C.; Pluvinet, Raquel; Bayés, Mònica; Himmelbauer, Heinz; del Río, José Antonio; Martí, Eulàlia; Sumoy Van Dyck, Lauro (BioMed Central, 2013)
    Background: Epidermal Growth Factor (EGF) plays an important function in the regulation of cell growth, proliferation, and differentiation by binding to its receptor (EGFR) and providing cancer cells with increased survival ...
  • Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis
    Llorens, Franc; Hummel, Manuela; Pastor Ruiz, Javier; Ferrer Salvador, Anna; Pluvinet, Raquel; Vivancos Prellezo, Ana; Castillo Andreo, Esther; Iraola Guzman, Susana; Mosquera Miguel, Ana; González-Roca, Eva; Lozano, Juan José; Ingham, Matthew; Dohm, Juliane C.; Noguera, Marc; Kofler, Robert; Río, Jose Antonio del; Bayés, Mònica; Himmelbauer, Heinz; Sumoy Van Dyck, Lauro (BioMed Central, 2011)
    Background: Epidermal Growth Factor (EGF) is a key regulatory growth factor activating many processes relevant to normal development and disease, affecting cell proliferation and survival. Here we use a combined approach ...