Browsing by Author "Hernandez-Alias, Xavier"

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  • From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation
    Ghose, Ritobrata; Aranguren-Ibáñez, Álvaro; Arecco, Niccolò; Balboa, Diego; Bataller, Marc; Beltran, Sergi; Benisty, Hannah, 1986-; Bénard, Angèle; Bernardo, Edgar; Carbonell Sala, Silvia; Casals, Eloi; Ciampi, Ludovica; Condemi, Livia; Corvò, Alberto; Cosín Tomàs, Marta; Cuenca-Ardura, Mirabai; Duran Serrano, Juan Manuel; Espejo Díaz, María Isabel; Fernández Callejo, Marcos; Gañez-Zapater, Antoni; Garcia-Castellanos, Raquel; Garrido, Romina; Henkin, Gil; Hermoso Pulido, Antonio; Hernandez-Alias, Xavier; Herrero Vicente, Jorge; Ingham, Matthew; Lim, Wei Ming; Llonch, Sílvia; Marmesat Bertoli, Elena; Miguel Escalada, Irene; Montero-Blay, Ariadna, 1994-; Navarrete Hernández, Cristina; Neguembor, Maria Victoria; Ní Chárthaigh, Róisín-Ana; Pardo-Lorente, Natalia; Pascual-Reguant, Laura, 1990-; Pérez-Lluch, Sílvia; Perza, Reyes; Pesaresi, Martina, 1991-; Picó Amado, Daniel; Pifarré, Paula; Piscia, Davide; Plana-Carmona, Marcos; Ponomarenko, Julia; Radusky, Leandro; Rivero, Ezequiel; Rogalska, Malgorzata; Torcal Garcia, Guillem, 1991-; Wojnacki, José (F1000Research, 2020)
    The COVID-19 pandemic has posed and is continuously posing enormous societal and health challenges worldwide. The research community has mobilized to develop novel projects to find a cure or a vaccine, as well as to ...
  • In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species
    Delgado Blanco, Javier; Hernandez-Alias, Xavier; Cianferoni, Damiano; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2020)
    The coronavirus disease COVID-19 constitutes the most severe pandemic of the last decades having caused more than 1 million deaths worldwide. The SARS-CoV-2 virus recognizes the angiotensin converting enzyme 2 (ACE2) on ...
  • Mutation bias within oncogene families is related to proliferation-specific codon usage
    Benisty, Hannah, 1986-; Weber, Marc; Hernandez-Alias, Xavier; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (National Academy of Sciences, 2020)
    It is well known that in cancer gene families some members are more frequently mutated in tumor samples than their family counterparts. A paradigmatic case of this phenomenon is KRAS from the RAS family. Different explanations ...
  • Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers
    Head, Sarah A.; Hernandez-Alias, Xavier; Yang, Jae-Seong; Ciampi, Ludovica; Beltran-Sastre, Violeta; Torres Méndez, Antonio, 1992-; Irimia Martínez, Manuel; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2021)
    RNA splicing is widely dysregulated in cancer, frequently due to altered expression or activity of splicing factors (SFs). Microexons are extremely small exons (3-27 nucleotides long) that are highly evolutionarily conserved ...
  • Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation
    Hernandez-Alias, Xavier; Katanski, Christopher D.; Zhang, Wen; Assari, Mahdi; Watkins, Christopher P.; Schaefer, Martin H.; Serrano Pubull, Luis, 1982-; Pan, Tao (Oxford University Press, 2023)
    Transfer RNA (tRNA) utilizes multiple properties of abundance, modification, and aminoacylation in translational regulation. These properties were typically studied one-by-one; however, recent advance in high throughput ...
  • Translational adaptation of human viruses to the tissues they infect
    Hernandez-Alias, Xavier; Benisty, Hannah, 1986-; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (Cell Press, 2021)
    Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting ...
  • Translational efficiency across healthy and tumor tissues is proliferation-related
    Hernandez-Alias, Xavier; Benisty, Hannah, 1986-; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (Wiley-VCH Verlag, 2020)
    Different tissues express genes with particular codon usage and anticodon tRNA repertoires. However, the codon-anticodon co-adaptation in humans is not completely understood, nor is its effect on tissue-specific protein ...
  • Using protein-per-mRNA differences among human tissues in codon optimization
    Hernandez-Alias, Xavier; Benisty, Hannah, 1986-; Radusky, Leandro; Serrano Pubull, Luis, 1982-; Schaefer, Martin H. (BioMed Central, 2023)
    Background: Codon usage and nucleotide composition of coding sequences have profound effects on protein expression. However, while it is recognized that different tissues have distinct tRNA profiles and codon usages in ...

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