Browsing by Author "Hernández, José-Ángel"

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A high proportion of cells carrying trisomy 12 is associated with a worse outcome in patients with chronic lymphocytic leukemia

González Gascón y Marín, Isabel; Puiggros Metje, Anna Maria; Espinet Solà, Blanca; Hernández, José-Ángel; Grupo Español de Leucemia Linfática Crónica (GELLC); Grupo Cooperativo Español de Citogenética Hematológica (GCECGH) (Wiley, 2014)

The prognosis of chronic lymphocytic leukemia (CLL) patients displaying trisomy 12 (+12) remains unclear. In this study, we analyzed the influence of the proportion of cells with +12, and other clinical and biologic factors, ...
A low frequency of losses in 11q chromosome is associated with better outcome and lower rate of genomic mutations in patients with chronic lymphocytic leukemia.

Hernández, José-Ángel; Puiggros Metje, Anna Maria; Espinet Solà, Blanca; Hernández-Rivas, Jesús María; Grupo Cooperativo Español de Citogenética Hematológica (GCECGH); Grupo Español de Leucemia Linfática Crónica (GELLC) (Public Library of Science, 2015)

To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first therapy (TFT) and overall survival (OS), 2,493 patients with CLL were studied. 242 patients (9.7%) had 11q-. Fluorescence in situ ...

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