Browsing by Author "Heeman, Fiona"

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  • Heeman, Fiona; Yaqub, Maqsood; Hendriks, Janine; van Berckel, Bart N. M.; Collij, Lyduine E.; Gray, Katherine R.; Manber, Richard; Wolz, Robin; Garibotto, Valentina; Wimberley, Catriona; Ritchie, Craig; Barkhof, Frederik; Gispert López, Juan Domingo; Vállez García, David; Lopes Alves, Isadora; Lammertsma, Adriaan A.; AMYPAD Consortium (SpringerOpen, 2022)
    Background: despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially explained by changes in ...
  • Heeman, Fiona; Yaqub, Maqsood; Lopes Alves, Isadora; Heurling, Kerstin; Berkhof, Johannes; Gispert López, Juan Domingo; Bullich, Santiago; Foley, Christopher; Lammertsma, Adriaan A.; AMYPAD Consortium (Springer, 2019)
    Background: A long dynamic scanning protocol may be required to accurately measure longitudinal changes in amyloid load. However, such a protocol results in a lower patient comfort and scanning efficiency compared to static ...
  • Heeman, Fiona; Yaqub, Maqsood; Hendriks, Janine; Bader, Ilona; Barkhof, Frederik; Gispert López, Juan Domingo; van Berckel, Bart N. M.; Lopes Alves, Isadora; Lammertsma, Adriaan A. (Elsevier, 2021)
    Optimal pharmacokinetic models for quantifying amyloid beta (Aβ) burden using both [18F]flutemetamol and [18F]florbetaben scans have previously been identified at a region of interest (ROI) level. The purpose of this study ...
  • Pemberton, Hugh G.; Collij, Lyduine E.; Heeman, Fiona; Bollack, Ariane; Shekari, Mahnaz; Salvadó, Gemma; Lopes Alves, Isadora; Vallez Garcia, David; Battle, Mark; Buckley, Christopher, 1948-; Stephens, Andrew W.; Bullich, Santiago; Garibotto, Valentina; Barkhof, Frederik; Gispert López, Juan Domingo; Farrar, Gill; AMYPAD Consortium (Springer, 2022)
    Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be determined in vivo using positron emission ...
  • Heeman, Fiona; Yaqub, Maqsood; Lopes Alves, Isadora; Heurling, Kerstin; Bullich, Santiago; Gispert López, Juan Domingo; Boellaard, Ronald; Lammertsma, Adriaan A.; AMYPAD Consortium (SAGE Publications, 2021)
    Global and regional changes in cerebral blood flow (CBF) can result in biased quantitative estimates of amyloid load by PET imaging. Therefore, the current simulation study assessed effects of these changes on amyloid ...
  • Collij, Lyduine E.; Salvadó, Gemma; Wottschel, Viktor; Mastenbroek, Sophie E.; Schoenmakers, Pierre; Heeman, Fiona; Aksman, Leon; Wink, Alle Meije; Berckel, Bart N.M.; van de Flier, Wiesje M.; Scheltens, Philip; Visser, Pieter Jelle; Barkhof, Frederik; Haller, Sven; Gispert López, Juan Domingo; Lopes Alves, Isadora; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Lippincott Williams & Wilkins, 2022)
    Background and objectives: β-amyloid (Aβ) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation subtypes by applying the data-driven Subtype and Stage ...
  • Lopes Alves, Isadora; Heeman, Fiona; Collij, Lyduine E.; Salvadó, Gemma; Tolboom, Nelleke; Vilor Tejedor, Natàlia, 1988-; Markiewicz, Pawel; Yaqub, Maqsood; Cash, David; Mormino, Elizabeth C.; Insel, Philip S.; Boellaard, Ronald; van Berckel, Bart N. M.; Lammertsma, Adriaan A.; Barkhof, Frederik; Gispert López, Juan Domingo (BioMed Central, 2021)
    Background: Detecting subtle-to-moderate biomarker changes such as those in amyloid PET imaging becomes increasingly relevant in the context of primary and secondary prevention of Alzheimer's disease (AD). This work aimed ...

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