Browsing by Author "Heath, Simon"

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  • Esteve-Codina, Anna; Arpí Llucià, Oriol; Martínez-García, Maria; Pineda, Estela; Mallo, Mar; Gut, Marta; Carrato, Cristina; Rovira Guerín, Ana; Lopez, Raquel; Tortosa, Avelina; Dabad, Marc; Del Barco, Sonia; Heath, Simon; Bagué, Silvia; Ribalta, Teresa; Alameda Quitllet, Francisco; de la Iglesia, Nuria; Balaña, Carmen; GLIOCAT Group (Public Library of Science (PLoS), 2017)
    The molecular classification of glioblastoma (GBM) based on gene expression might better explain outcome and response to treatment than clinical factors. Whole transcriptome sequencing using next-generation sequencing ...
  • Feichtinger, Julia; Hernández, Inmaculada; Fischer, Christoph; Hanscho, Michael; Auer, Norbert; Hackl, Matthias; Jadhav, Vaibhav; Baumann, Martina; Krempl, Peter M.; Schmidl, Christian; Farlik, Matthias; Schuster, Michael; Merkel, Angelika; Sommer, Andreas; Heath, Simon; Rico, Daniel; Bock, Christoph; Thallinger, Gerhard R.; Borth, Nicole (Wiley, 2016)
    The most striking characteristic of CHO cells is their adaptability, which enables efficient production of proteins as well as growth under a variety of culture conditions, but also results in genomic and phenotypic ...
  • Laurie, Steven, 1973-; Fernández Callejo, Marcos; Marco Sola, Santiago; Trotta, Jean-Remi; Camps, Jordi; Chacón, Alejandro; Espinosa, Antonio; Gut, Marta; Gut, Ivo Glynne; Heath, Simon; Beltran, Sergi (Wiley, 2016)
    As whole genome sequencing becomes cheaper and faster, it will progressively substitute targeted next-generation sequencing as standard practice in research and diagnostics. However, computing cost–performance ratio is not ...
  • Merkel, Angelika; Fernández Callejo, Marcos; Casals, Eloi; Marco Sola, Santiago; Schuyler, Ronald P.; Gut, Ivo Glynne; Heath, Simon (Oxford University Press, 2019)
    Motivation: DNA methylation is essential for normal embryogenesis and development in mammals and can be captured at single base pair resolution by whole genome bisulfite sequencing (WGBS). Current available analysis tools ...
  • Paul, Dirk S.; Heath, Simon; Gut, Marta; Gut, Ivo Glynne; Leslie, R. David (Nature Publishing Group, 2016)
    The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic mechanisms in disease development. Here we present an epigenome-wide ...
  • Ventham, N. T.; Kennedy, N. A.; Adams, A. T.; Kalla, Rahul; Heath, Simon; O'Leary, K. R.; Drummond, H.; IBD BIOM consortium; IBD CHARACTER consortium; Wilson, D. C.; Gut, Ivo Glynne; Nimmo, E. R.; Satsangi, Jack (Nature Publishing Group, 2016)
    Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences in 240 newly-diagnosed IBD cases and ...
  • Guillaumet-Adkins, Amy; Rodríguez Esteban, Gustavo; Mereu, Elisabetta; Méndez Lago, María; Jaitin, Diego Adhemar; Villanueva, Alberto; Vidal, August; Martínez Martí, Alex; Felip, Enriqueta; Vivancos Prellezo, Ana; Keren-Shaul, Hadas; Heath, Simon; Gut, Marta; Amit, Ido; Gut, Ivo Glynne; Heyn, Holger (BioMed Central, 2017)
    A variety of single-cell RNA preparation procedures have been described. So far, protocols require fresh material, which hinders complex study designs. We describe a sample preservation method that maintains transcripts ...
  • Argilaguet Marqués, Jordi, 1977-; Pedragosa Marín, Mireia, 1988-; Esteve-Codina, Anna; Riera Domínguez, María Graciela, 1987-; Vidal, Enric; Peligero Cruz, Cristina, 1986-; Casella, Valentina; Andreu Martínez, David; Kaisho, Tsuneyasu; Bocharov, Gennady A.; Ludewig, Burkhard; Heath, Simon; Meyerhans, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune ...