Browsing by Author "Guix Ràfols, Francesc Xavier"

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  • Activation of PKR causes amyloid beta-peptide accumulation via De-Repression of Bace1 expression
    Ill-Raga, Gerard, 1982-; Palomer, Ernest; Wozniak, Matthew A; Ramos Fernández, Eva, 1984-; Bosch Morató, Mònica, 1986-; Tajes Orduña, Marta; Guix Ràfols, Francesc Xavier; Galán, José J; Clarimón Echevarría, Jordi; Antúnez, Carmen; Real, Luis M; Boada, Mercè; Itzhaki, Ruth F; Fandos, César; Muñoz López, Francisco José, 1964- (Public Library of Science (PLoS), 2011)
    BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5′untranslated region (5′UTR) ...
  • Amyloid beta-peptide increases BACE1 translation through the phosphorylation of the eukaryotic initiation factor-2 α
    Picón-Pagès, Pol; Gutiérrez, Daniela A.; Barranco Almohalla, Alejandro; Crepin, Giulia; Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Guix Ràfols, Francesc Xavier; Menéndez, Silvia; Arumí Uría, Montserrat; Vicente García, Rubén, 1978-; Álvarez, Alejandra R.; Muñoz López, Francisco José, 1964- (Hindawi, 2020)
    Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity ...
  • Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death
    Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Tajes Orduña, Marta; Valls Comamala, Victòria, 1987-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Gil Gómez, Gabriel; Alameda Quitllet, Francisco; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Elsevier, 2015)
    Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide ...
  • Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease
    Tajes Orduña, Marta; Eraso Pichot, Abel; Rubio Moscardó, Fanny; Guivernau Almazán, Biuse, 1988-; Ramos Fernández, Eva, 1984-; Bosch Morató, Mònica, 1986-; Guix Ràfols, Francesc Xavier; Clarimón Echevarría, Jordi; Miscione, Gian Pietro; Boada, Mercè; Gil Gómez, Gabriel; Suzuki, Toshiharu; Molina, Henrik; Villà i Freixa, Jordi; Vicente García, Rubén, 1978-; Muñoz López, Francisco José, 1964- (IOS Press, 2014)
    Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of the most strongly nitrotyrosinated proteins in AD is the ...
  • Modification of y-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
    Guix Ràfols, Francesc Xavier; Wahle, Tina; Vennekens, Kristel; Snellinx, An; Chávez Gutiérrez, Lucía; Ill-Raga, Gerard, 1982-; Ramos Fernández, Eva, 1984-; Guardia Laguarta, Cristina; Lleó, Alberto; Arimon, Muriel; Berezovska, Oksana; Muñoz López, Francisco José, 1964-; Dotti, Carlos G.; De Strooper, Bart (Wiley-VCH Verlag, 2012)
    Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients. Little is known ...
  • Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death
    Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Pérez Asensio, Fernando; Reyes Navarro, Mario; Caballo, Carolina; Galán, Ana M.; Alameda Quitllet, Francisco; Escolar, Ginès; Opazo, Carlos M.; Planas, Anna; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Hindawi, 2013)
    Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also glial and brain vessel cells. Immediately after the stroke, the ischemic ...
  • Physiological control of nitric oxide in neuronal BACE1 translation by heme-regulated eIF2α kinase HRI induces synaptogenesis
    Ill-Raga, Gerard, 1982-; Tajes Orduña, Marta; Busquets Garcia, Arnau, 1985-; Ramos Fernández, Eva, 1984-; Vargas, Lina M.; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Eraso Pichot, Abel; Guix Ràfols, Francesc Xavier; Fandos, César; Rosen, Mark D.; Rabinowitz, Michael H.; Maldonado, Rafael, 1961-; Álvarez, Alejandra R.; Ozaita Mintegui, Andrés, 1969-; Muñoz López, Francisco José, 1964- (Mary Ann Liebert, Inc, 2015)
    AIMS: Hippocampus is the brain center for memory formation, a process that requires synaptogenesis. However, hippocampus is dramatically compromised in Alzheimer's disease due to the accumulation of amyloid β-peptide, whose ...
  • Study of the pathophysiological role of nitric oxide on the amyloid-induced toxicity attending to the biochemical modifications and cellular damages
    Guix Ràfols, Francesc Xavier (Universitat Pompeu Fabra, 2009-01-22)
    Aquesta tesi demostra que el peroxinitrit produït com a conseqüència del pèptid beta-amiloide (A) contribueix l'augment de la relació A42/A40 que ocorre a la malaltia d'Alzheimer. L'A42 ...