Browsing by Author "Guitart, Tanit"

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  • A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons
    Torres Méndez, Antonio; Bonnal, Sophie; Marquez, Yamile; Roth, Jonathan; Iglesias, Marta; Permanyer, Jon; Almudi, Isabel; O'Hanlon, Dave; Guitart, Tanit; Soller, Matthias; Gingras, Anne-Claude; Gebauer, Fátima; Rentzsch, Fabian; Blencowe, Benjamin J.; Valcárcel, J. (Juan); Irimia Martínez, Manuel (Nature Research, 2019)
    The mechanisms by which entire programmes of gene regulation emerged during evolution are poorly understood. Neuronal microexons represent the most conserved class of alternative splicing in vertebrates, and are critical ...
  • Ataxin-2, Twenty-four, and Dicer-2 are components of a noncanonical cytoplasmic polyadenylation complex
    Nadimpalli, Hima Priyanka, 1988-; Guitart, Tanit; Coll, Olga; Gebauer, Fátima (Life Science Alliance, 2022)
    Cytoplasmic polyadenylation is a mechanism to promote mRNA translation in a wide variety of biological contexts. A canonical complex centered around the conserved RNA-binding protein family CPEB has been shown to be ...
  • Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1
    Avolio, Rosario; Inglés Ferrándiz, Marta, 1989-; Ciocia, Annagiulia; Coll, Olga; Bonnin, Sarah; Guitart, Tanit; Ribó Rubio, Anna; Gebauer, Fátima (Elsevier, 2022)
    Oncogene-induced senescence (OIS) is a form of stable cell-cycle arrest arising in response to oncogenic stimulation. OIS must be bypassed for transformation, but the mechanisms of OIS establishment and bypass remain poorly ...
  • CSDE1 controls gene expression through the miRNA-mediated decay machinery
    Kakumani, Pavan Kumar; Harvey, Louis-Mathieu; Houle, François; Guitart, Tanit; Gebauer, Fátima; Simard, Martin J. (Life Science Alliance, 2020)
    In animals, miRNAs are the most prevalent small non-coding RNA molecules controlling posttranscriptional gene regulation. The Argonaute proteins (AGO) mediate miRNA-guided gene silencing by recruiting multiple factors ...
  • CSDE1 intracellular distribution as a biomarker of melanoma prognosis
    Indacochea Cusirramos, Alberto; Guitart, Tanit; Boada, Aram; Peg, Vicente; Quer, Ariadna; Laayouni, Hafid, 1968-; Condal, Laura; Espinosa, Pablo; Manzano Mozo, José Luis; Gebauer, Fátima (MDPI, 2024)
    RNA-binding proteins are emerging as critical modulators of oncogenic cell transformation, malignancy and therapy resistance. We have previously found that the RNA-binding protein Cold Shock Domain containing protein E1 ...
  • CSDE1: a versatile regulator of gene expression in cancer
    Ciocia, Annagiulia; Mestre Farràs, Neus; Vicent Nacht, Ignacio; Guitart, Tanit; Gebauer, Fátima (Oxford University Press, 2024)
    RNA-binding proteins (RBPs) have garnered significant attention in the field of cancer due to their ability to modulate diverse tumor traits. Once considered untargetable, RBPs have sparked renewed interest in drug ...
  • Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation
    Coll, Olga; Guitart, Tanit; Villalba, Ana; Papin, Catherine; Simonelig, Martine; Gebauer, Fátima (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    Cytoplasmic polyadenylation is a widespread mechanism to regulate mRNA translation. In vertebrates, this process requires two sequence elements in target 3' UTRs: the U-rich cytoplasmic polyadenylation element and the ...
  • Hrp48 and eIF3d contribute to msl-2 mRNA translational repression
    Szóstak, Emilia, 1984-; García Beyaert, Marina, 1983-; Guitart, Tanit; Graindorge, Antoine; Coll, Olga; Gebauer, Fátima (Oxford University Press, 2018)
    Translational repression of msl-2 mRNA in females of Drosophila melanogaster is an essential step in the regulation of X-chromosome dosage compensation. Repression is orchestrated by Sex-lethal (SXL), which binds to both ...
  • Pseudo-RNA-binding domains mediate RNA structure specificity in upstream of N-Ras
    Hollmann, Nele Merret; Jagtap, Pravin Kumar Ankush; Masiewicz, Pawel; Guitart, Tanit; Simon, Bernd; Provaznik, Jan; Stein, Frank; Haberkant, Per; Sweetapple, Lara Jayne; Villacorta, Laura; Mooijman, Dylan; Benes, Vladimir; Savitski, Mikhail M.; Gebauer, Fátima; Hennig, Janosch (Elsevier, 2020)
    RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs), which provide these proteins with a modular architecture. Accumulating evidence supports that RBP architectural modularity and adaptability ...

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