Browsing by Author "Groop, Leif"

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  • Genome editing of human pancreatic beta cell models: problems, possibilities and outlook
    Balboa, Diego; Prasad, Rashmi B.; Groop, Leif; Otonkoski, Timo (Springer, 2019)
    Understanding the molecular mechanisms behind beta cell dysfunction is essential for the development of effective and specific approaches for diabetes care and prevention. Physiological human beta cell models are needed ...
  • The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
    Chandra, Vikash; Ibrahim, Hazem; Halliez, Clémentine; Prasad, Rashmi B.; Vecchio, Federica; Dwivedi, Om Prakash; Kvist, Jouni; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam; Barsby, Tom; Lithovius, Väinö; Artner, Isabella; Gopalakrishnan, Swetha; Groop, Leif; Mallone, Roberto; Eizirik, Décio L.; Otonkoski, Timo (Nature Research, 2022)
    Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in ...