Browsing by Author "Graupera, Mariona"

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  • DYRK1A kinase positively regulates angiogenic responses in endothelial cells
    Rozen, Esteban J.; Roewenstrunk, Julia Maria, 1981-; Barallobre, María José; Di Vona, Chiara, 1981-; Jung, Carole; Figueiredo, Ana F.; Luna, Jeroni; Fillat i Fonts, Cristina; Arbonés de Rafael, Maria Lourdes, 1959-; Graupera, Mariona; Valverde, M. A. (Miguel Ángel), 1963-; Luna Gargantilla, Susana de la (Elsevier, 2018)
    Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells ...
  • Sequential functions of CPEB1 and CPEB4 regulate pathologic expression of vascular endothelial growth factor and angiogenesis in chronic liver disease.
    Calderone, Vittorio; Gallego, Javier; Fernandez Miranda, Gonzalo; Garcia Pras, Ester; Maillo, Carlos; Berzigotti, Annalisa; Mejias, Marc; Bava, Felice Alessio; Angulo Urarte, Ana; Graupera, Mariona; Pilar, Navarro Medrano; Bosch, Jaime; Fernandez, Mercedes; Méndez Giraldez, Raúl (Elsevier, 2016)
    BACKGROUND & AIMS: Vascular endothelial growth factor (VEGF) regulates angiogenesis, yet therapeutic strategies to disrupt VEGF signaling can interfere with physiologic angiogenesis. In a search for ways to inhibit pathologic ...
  • The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice
    Ribera, Jordi; Portolés, Irene; Córdova-Jover, Bernat; Rodríguez-Vita, Juan; Casals, Gregori; Gónzalez-de la Presa, Bernardino; Graupera, Mariona; Solsona-Vilarrasa, Estel; Garcia-Ruiz, Carmen; Fernández-Checa, José C.; Soria Rodríguez, Guadalupe; Tudela, Raúl; Esteve-Codina, Anna; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Jiménez, Wladimiro; Sessa, William C.; Morales-Ruiz, Manuel (Nature Research, 2021)
    DHX15 is a downstream substrate for Akt1, which is involved in key cellular processes affecting vascular biology. Here, we explored the vascular regulatory function of DHX15. Homozygous DHX15 gene deficiency was lethal in ...
  • The onset of PI3K-related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib
    Kobialka, Piotr; Sabata, Helena; Vilalta, Odena; Gouveia, Leonor; Angulo-Urarte, Ana; Muixí, Laia; Zanoncello, Jasmina; Muñoz-Aznar, Oscar; Olaciregui, Nagore G.; Fanlo, Lucía; Esteve-Codina, Anna; Lavarino, Cinzia; Javierre, Biola M.; Celis-Passini, Veronica Paola; Rovira, Carlota; López-Fernández, Susana; Baselga, Eulàlia; Mora, Jaume; Castillo, Sandra D.; Graupera, Mariona (Wiley, 2022)
    Low-flow vascular malformations are congenital overgrowths composed of abnormal blood vessels potentially causing pain, bleeding and obstruction of different organs. These diseases are caused by oncogenic mutations in the ...