Browsing by Author "Grau Bové, Xavier"

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  • A genomic survey of HECT ubiquitin ligases in eukaryotes reveals independent expansions of the HECT system in several lineages
    Grau Bové, Xavier; Sebé-Pedrós, Arnau; Ruiz Trillo, Iñaki (Oxford University Press, 2013)
    The posttranslational modification of proteins by the ubiquitination pathway is an important regulatory mechanism in eukaryotes. To date, however, studies on the evolutionary history of the proteins involved in this pathway ...
  • A stony coral cell atlas illuminates the molecular and cellular basis of coral symbiosis, calcification, and immunity
    Levy, Shani; Elek, Anamaria; Grau Bové, Xavier; Menéndez Bravo, Simón; Iglesias, Marta; Tanay, Amos; Mass, Tali; Sebé-Pedrós, Arnau (Elsevier, 2021)
    Stony corals are colonial cnidarians that sustain the most biodiverse marine ecosystems on Earth: coral reefs. Despite their ecological importance, little is known about the cell types and molecular pathways that underpin ...
  • A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization
    Dudin, Omaya; Ondracka, Andrej; Grau Bové, Xavier; Haraldsen, Arthur A. B.; Toyoda, Atsushi; Suga, Hiroshi; Bråte, Jon; Ruiz Trillo, Iñaki (eLife, 2019)
    In animals, cellularization of a coenocyte is a specialized form of cytokinesis that results in the formation of a polarized epithelium during early embryonic development. It is characterized by coordinated assembly of an ...
  • An amphioxus neurula stage cell atlas supports a complex scenario for the emergence of vertebrate head mesoderm
    Grau Bové, Xavier; Subirana, Lucie; Meister, Lydvina; Soubigou, Anaël; Neto, Ana; Elek, Anamaria; Naranjo, Silvia; Fornas Carreño, Oscar; Gómez Skarmeta, José Luis; Tena, Juan J.; Irimia Martínez, Manuel; Bertrand, Stéphanie; Sebé-Pedrós, Arnau; Escriva, Hector (Nature Research, 2024)
    The emergence of new structures can often be linked to the evolution of novel cell types that follows the rewiring of developmental gene regulatory subnetworks. Vertebrates are characterized by a complex body plan compared ...
  • Conservative route to genome compaction in a miniature annelid
    Irimia Martínez, Manuel; Vellutini, Bruno C.; Marlétaz, Ferdinand; Cetrangolo, Viviana; Cvetesic, Nevena; Thiel, Daniel; Henriet, Simon; Grau Bové, Xavier; Carrillo-Baltodano, Allan M.; Gu, Wenjia; Kerbl, Alexandra; Marquez, Yamile; Bekkouche, Nicolas; Chourrout, Daniel; Gómez Skarmeta, José Luis; Lenhard, Boris; Worsaae, Katrine; Hejnol, Andreas (Nature Research, 2020)
    The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact ...
  • Evaluation of single-cell genomics to address evolutionary questions using three SAGs of the choanoflagellate Monosiga brevicollis
    López Escardó, David, 1988-; Grau Bové, Xavier; Guillaumet-Adkins, Amy; Gut, Marta; Sieracki, Michael E.; Ruiz Trillo, Iñaki (Nature Publishing Group, 2017)
    Single-cell genomics (SCG) appeared as a powerful technique to get genomic information from uncultured organisms. However, SCG techniques suffer from biases at the whole genome amplification step that can lead to extremely ...
  • Functional and genomic comparative study of the bitter taste receptor family TAS2R: Insight into the role of human TAS2R5
    Grau-Bové, Carme; Grau Bové, Xavier; Terra, Ximena; Garcia Vallvé, Santiago; Rodríguez-Gallego, Esther; Beltran-Debón, Raúl; Blay, M. Teresa; Ardévol, Anna; Pinent, Montserrat (Wiley, 2022)
    Bitterness is perceived in humans by 25 subtypes of bitter taste receptors (hTAS2R) that range from broadly tuned to more narrowly tuned receptors. hTAS2R5 is one of the most narrowly tuned bitter taste receptors in humans. ...
  • Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture
    Grau Bové, Xavier; Ruiz Trillo, Iñaki; Irimia Martínez, Manuel (BioMed Central, 2018)
    Background: Alternative splicing, particularly through intron retention and exon skipping, is a major layer of pre-translational regulation in eukaryotes. While intron retention is believed to be the most prevalent mode ...
  • Orthology clusters from gene trees with possvm
    Grau Bové, Xavier; Sebé-Pedrós, Arnau (Oxford University Press, 2021)
    Possvm (Phylogenetic Ortholog Sorting with Species oVerlap and MCL [Markov clustering algorithm]) is a tool that automates the process of identifying clusters of orthologous genes from precomputed phylogenetic trees and ...
  • Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
    López Escardó, David, 1988-; Grau Bové, Xavier; Guillaumet-Adkins, Amy; Gut, Marta; Sieracki, Michael E.; Ruiz Trillo, Iñaki (Royal Society, 2019)
    Understanding the origins of animal multicellularity is a fundamental biological question. Recent genome data have unravelled the role that co-option of pre-existing genes played in the origin of animals. However, there ...
  • Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity
    Robertson, Helen E.; Sebé-Pedrós, Arnau; Saudemont, Baptiste; Loe-Mie, Yann; Zakrzewski, Anne-C.; Grau Bové, Xavier; Mailhe, Marie-Pierre; Schiffer, Philipp H.; Telford, Maximilian J.; Marlow, Heather (Nature Research, 2024)
    Phylogenetic analyses over the last two decades have united a few small, and previously orphan clades, the nematodermatids, acoels and xenoturbelids, into the phylum Xenacoelomorpha. Some phylogenetic analyses support a ...
  • Stepwise emergence of the neuronal gene expression program in early animal evolution
    Najle, Sebastián R.; Grau Bové, Xavier; Elek, Anamaria; Navarrete Hernández, Cristina; Cianferoni, Damiano; Chiva, Cristina; Cañas Armenteros, Didac; Mallabiabarrena, Arrate; Kamm, Kai; Sabidó Aguadé, Eduard, 1981-; Gruber-Vodicka, Harald; Schierwater, Bernd; Serrano Pubull, Luis, 1982-; Sebé-Pedrós, Arnau (Elsevier, 2023)
    The assembly of the neuronal and other major cell type programs occurred early in animal evolution. We can reconstruct this process by studying non-bilaterians like placozoans. These small disc-shaped animals not only have ...

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