Browsing by Author "Gratacós Mayora, Mònica"

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  • Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders
    Muiños Gimeno, Margarita; Guidi, Mònica; Kagerbauer, Birgit; Martín Santos, Rocío; Navinés, Ricard; Alonso, Pino; Menchón, José M.; Gratacós Mayora, Mònica; Estivill, Xavier, 1955-; Espinosa Parrilla, Yolanda, 1971- (Wiley-Blackwell, 2009)
    Genetic and functional data indicate that variation in the expression of the neurotrophin-3 receptor gene (NTRK3) may have an impact on neuronal plasticity, suggesting a role for NTRK3 in the pathophysiology of anxiety ...
  • Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia
    Mercader Bigas, Josep Maria; Ribasés, Marta; Gratacós Mayora, Mònica; González Ruiz, Juan Ramón; Bayés, Mònica; Cid Ibeas, Rafael de; Badía, Anna; Fernández Aranda, Fernando; Estivill, Xavier, 1955- (John Wiley & Sons, 2007)
    Murine models and association studies in eating disorder (ED) patients have shown a role for the brain-derived neurotrophic factor (BDNF) in eating behavior. Some studies have shown association of BDNF -270C/T single-nucleotide ...
  • Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders
    Mercader Bigas, Josep Maria; Saus Martínez, Ester; Agüera, Zaida; Bayés, Mònica; Boni, Claudette; Carreras, Anna; Cellini, Elena; Cid Ibeas, Rafael de; Dierssen, Mara; Escaramís, Geòrgia; Fernández Aranda, Fernando; Forcano, Laura; Gallego, Xavier; González Ruiz, Juan Ramón; Gorwood, Philip; Hebebrand, Johannes; Hinney, Anke; Nacmias, Benedetta; Puig, Anna; Ribasés, Marta; Ricca, Valdo; Romo, Lucía; Sorbi, Sandro; Versini, Audrey; Gratacós Mayora, Mònica; Estivill, Xavier, 1955- (Oxford University Press, 2008)
    Eating disorders (EDs) are complex psychiatric diseases that include anorexia nervosa and bulimia nervosa, and have higher than 50% heritability. Previous studies have found association of BDNF and NTRK2 to ED, while animal ...
  • Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patients
    Mercader Bigas, Josep Maria; Fernández Aranda, Fernando; Gratacós Mayora, Mònica; Ribasés, Marta; Badía, Anna; Villarejo, Cynthia; Solano, Raquel; González Ruiz, Juan Ramón; Vallejo, Julio; Estivill, Xavier, 1955- (Karger (S. Karger AG), 2007)
    Background: Evidence of a role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of eating disorders (ED) has been provided by association studies and by murine models. BDNF plasma levels have been found ...
  • Factor structure of the spanish version of the Edinburgh postnatal depression scale
    Gutierrez-Zotes, Alfonso; Gallardo-Pujol, David; Labad, Javier; Martín Santos, Rocío; García-Esteve, Luisa; Gelabert, Estel; Jover, Manuel; Guillamat, Roser; Mayoral Cleries, Fermín; Gornemann, Isolde; Canellas, Francesca; Gratacós Mayora, Mònica; Guitart, Miriam; Roca, Miquel; Costas, Javier; Ivorra, Jose Luis; Navinés, Ricard; Diego, Yolanda de; Vilella, Elisabet; Sanjuan, Julio (Fundación López Ibor, 2018)
    INTRODUCTION: The Edinburgh Postnatal Depression Scale (EPDS) is considered the gold standard in screening for postpartum depression. Although the Spanish version has been widely used, its factorial structure has not yet ...
  • Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression.
    Udina, M. ; Navinés, Ricard; Egmond, E.  ; Oriolo, Giovanni; Langohr, Klaus; Gimenez, Dolors; Valdés, M. ; Gómez-Gil, E. ; Grande, Iria; Gratacós Mayora, Mònica; Kapczinski, F.  ; Artigas, Francesc; Vieta, Eduard; Solà, Rosa; Martín Santos, Rocío (Oxford University Press, 2016)
    BACKGROUND: The role of inflammation in mood disorders has received increased attention. There is substantial evidence that cytokine therapies, such as interferon alpha (IFN-alpha), can induce depressive symptoms. Indeed, ...
  • Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model
    Mercader Bigas, Josep Maria; Lozano, Juan José; Sumoy Van Dyck, Lauro; Dierssen, Mara; Visa, Joana; Gratacós Mayora, Mònica; Estivill, Xavier, 1955- (American Physiological Society, 2008)
    The anx/anx mouse displays poor appetite and lean appearance and is considered a good model for the study of anorexia nervosa. To identify new genes involved in feeding behavior and body weight regulation we performed an ...
  • Mecanismes moleculars en el transtorn de la conducta alimentària: estudis en humans i en model murins
    Mercader Bigas, Josep Maria (Universitat Pompeu Fabra, 2008-07-11)
    Els trastorns de la conducta alimentària (TCA) tenen una etiologia complexa en la que hi intervenen factors de predisposició socioculturals, ambientals i genètics. S'ha aprofundit en les bases moleculars dels TCA mitjançant ...
  • Study of genomic variability in the genetic susceptibility to psychiatric disorders: SNPs, CNVs and miRNAs
    Saus Martínez, Ester (Universitat Pompeu Fabra, 2010-11-24)
    In this thesis we have studied genetic elements potentially contributing to the pathophysiology of psychiatric disorders, focusing on different sources of human genome variability, including SNPs and CNVs, which can affect ...