Browsing by Author "Grande Posa, Luís"

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  • Quesada Diez, Rita; Poves Prim, José Ignacio; Berjano, Enrique J.; Vilaplana, Carles; Andaluz, Anna; Moll, Xavier; Dorcaratto, Dimitri; Grande Posa, Luís; Burdío Pinilla, Fernando (Taylor & Francis (Routledge), 2017)
    PURPOSE: To evaluate the impact of using monopolar thermal coagulation based on radiofrequency (RF) currents on intraoperative blood loss during liver resection. MATERIALS AND METHODS: A prospective randomised controlled ...
  • Sánchez-Velázquez, Joan; Castellví Fernández, Quim; Villanueva, Alberto; Quesada Diez, Rita; Pañella-Vilamú, Clara; Cáceres Aguilar, Mario; Dorcaratto, Dimitri; Andaluz, Anna; Moll, Xavier; Trujillo Guillén, Macarena; Burdío, José Miguel; Berjano, Enrique J.; Grande Posa, Luís; Ivorra Cano, Antoni, 1974-; Burdío Pinilla, Fernando (Nature Publishing Group, 2016-04-01)
    Irreversible electroporation is a fast-growing liver ablation technique. Although safety has been well documented in small ablations, our aim is to assess its safety and feasibility when a large portion of liver is ablated. ...
  • Quesada Diez, Rita; Poves Prim, José Ignacio; Iglesias Coma, Mar; Berjano, Enrique J.; Grande Posa, Luís; Burdío Pinilla, Fernando (SpringerOpen, 2016)
    Background: Although radiofrequency-assisted devices have sometimes been used in partial splenectomy, this is not a common technique. This report describes the first case of laparoscopic partial splenectomy using an ...
  • Poves Prim, José Ignacio; Morató Redondo, Olga; Burdío Pinilla, Fernando; Grande Posa, Luís (Springer, 2017)
    BACKGROUND: Laparoscopic pancreaticoduodenectomy (LPD) is a complex procedure that is becoming increasingly popular among surgeons. Postoperative pancreatic fistula (POPF) remains the most feared specific complication in ...
  • Ivorra Cano, Antoni, 1974-; Sánchez Velázquez, Patricia, 1985-; Castellví Fernández, Quim; Villanueva, Alberto; Iglesias Coma, Mar; Quesada Diez, Rita; Pañella-Vilamú, Clara; Cáceres Aguilar, Mario; Dorcaratto, Dimitri; Andaluz, Anna; Moll, Xavier; Burdío, José Miguel; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Publishing Group, 2017)
    Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with ...
  • Marcuello, María; Mayol Girbau, Xavier; Felipe-Fumero, Eloísa; Costa, Jaume; López-Hierro, Laia; Salvans Ruiz, Silvia; Alonso Gonçalves, Sandra; Pascual Damieta, Marta; Grande Posa, Luís; Pera Roman, Miguel; Peritoneal infection after colorectal cancer surgery is associated with a higher rate of tumor relapse. We have recently proposed that soluble inflammatory factors released in response to a postoperative infection enhance tumor progression features in residual tumor cells. In an effort to set up models to study the mechanisms of residual tumor cell activation during surgery-associated inflammation, we have analyzed the phenotypic response of colon cancer cell lines to the paracrine effects of THP-1 and U937 differentiated human macrophages, which release an inflammatory medium characteristic of an innate immune response. The exposure of the colon cancer cell lines HT-29 and SW620 to conditioned media isolated from differentiated THP-1 and U937 macrophages induced a mesenchymal-like phenotypic shift, involving the activation of in vitro invasiveness. The inflammatory media activated the β-catenin/TCF4 transcriptional pathway and induced the expression of several mesenchymal (e.g., FN1 and VIM) and TCF4 target genes (e.g., MMP7, PTGS2, MET, and CCD1). Similarly, differential expression of some transcription factors involved in epithelial-to-mesenchymal transitions (i.e. ZEB1, SNAI1, and SNAI2) was variably observed in the colon cancer cell lines when exposed to the inflammatory media. THP-1 and U937 macrophages, which displayed characteristics of M1 differentiation, overexpressed some cytokines previously shown to be induced in colorectal cancer patients with increased rates of tumor recurrence associated with postoperative peritoneal infections, thus suggesting their pro-tumoral character. Therefore, the environment created by inflammatory M1 macrophages enhances features of epithelial-to-mesenchymal transition, and may be useful as a model to characterize pro-inflammatory cytokines as putative biomarkers of tumor recurrence risk. (Public Library of Science (PLoS), 2018)
  • Goday Arno, Alberto; Farré Albaladejo, Magí; Rodríguez-Morató, Jose, 1987-; Ramón Moros, José Manuel; Pérez Mañá, Clara; Papaseit Fontanet, Esther; Civit, Ester; Langohr, Klaus; Carbó Banús, Marcel·lí; Benaiges Foix, David; Castañer, Olga; Flores-Le-Roux, Juana Antonia; Pera Roman, Manuel Ramón; Grande Posa, Luís; Torre Fornell, Rafael de la (Springer, 2017)
    PURPOSE: The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver ...
  • Climent Agustín, Marta Carmen; Hidalgo, Nils; Vidal, Óscar; Puig, Sonia; Iglesias García, Mar; Cuatrecasas, Miriam; Ramón Moros, José Manuel; Garcia-Albéniz, Xabier; Grande Posa, Luís; Pera Roman, Manuel Ramón (Elsevier, 2016)
    BACKGROUND: We assessed the impact of complications on recurrence and survival after curative gastric cancer resection. METHODS: Patients undergoing R0 resections between 1990 and 2009 were identified in a prospectively ...
  • Benaiges Foix, David; Sagué Vilavella, Maria; Flores-Le-Roux, Juana Antonia; Pedro-Botet, Juan Carlos; Ramón Moros, José Manuel; Villatoro Moreno, Montserrat; Chillarón Jordan, Juan José; Pera Roman, Manuel Ramón; Más-Lorenzo, Antonio; Grande Posa, Luís; Goday Arno, Alberto (Oxford University Press, 2016)
    BACKGROUND: Few data exist on factors associated with hypertension (HTN) remission post-bariatric surgery. No information on factors that may predict HTN relapse is available. The aims were to assess the HTN remission and ...
  • Argudo Aguirre, Nuria; Pera, Miguel; López-Cano, Manuel; Hernández Martínez, Lourdes; Sancho, Juan José; Grande Posa, Luís; Pereira Rodríguez, José Antonio (Frontiers, 2018)
  • Alonso Gonçalves, Sandra; Pérez Farré, Silvia; Argudo Aguirre, Nuria; Latorraca, José Isaac; Pascual Damieta, Marta; Álvarez González, Marco Antonio; Seoane, Agustín; Barranco Priego, Luis Eugenio; Grande Posa, Luís; Pera Roman, Miguel (Sociedad Española de Patología Digestiva (SEPD), 2018)
  • Climent Agustín, Marta Carmen; Munarriz, Marina; Blazeby, Jane M.; Dorcaratto, Dimitri; Ramón Moros, José Manuel; Carrera Santaliestra, M. José; Fontane Francia, Laia; Grande Posa, Luís; Pera Roman, Manuel Ramón (Elsevier, 2017)
    BACKGROUND: Malnutrition is common in patients undergoing gastric cancer resection, leading to weight loss, although little is known about how this impacts on health-related quality of life (HRQL). This study aimed to ...