Browsing by Author "Gonzalez, Juan Ramon"

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  • Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview
    Vrijheid, Martine; Basagaña Flores, Xavier; Gonzalez, Juan Ramon; Porcel, Joana; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Dadvand, Payam; Fossati, Serena; Guxens Junyent, Mònica; Maitre, Léa; Nieuwenhuijsen, Mark J.; Ortiz, Rodney; Stratakis, Nikos; Sunyer Deu, Jordi; Slama, Rémy (Wolters Kluwer (LWW), 2021)
    Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing ...
  • Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome
    Catuara Solarz, Silvina, 1986-; Espinosa-Carrasco, José; Erb, Ionas; Langohr, Klaus; Gonzalez, Juan Ramon; Notredame, Cedric; Dierssen, Mara (Society for Neuroscience, 2016)
    Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, ...
  • DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
    Joubert, Bonnie R.; Salas Díaz, Lucas Andrés, 1980-; Ruiz, Carlos; Bustamante Pineda, Mariona; Gonzalez, Juan Ramon; Pinart, Mariona; Guerra, Stefano; Vrijheid, Martine; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; London, Stephanie J. (Elsevier, 2016)
    Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child ...
  • Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study
    Maitre, Léa; Júlvez Calvo, Jordi; López Vicente, Mònica, 1988-; Warembourg, Charline; Tamayo-Uria, Ibon; Guxens Junyent, Mònica; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; de Castro, Montserrat; Gonzalez, Juan Ramon; Hernandez-Ferrer, Carles, 1987-; Marquez, Sandra; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Vrijheid, Martine (Elsevier, 2021)
    Background: Environmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad ...
  • Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
    Karlsson Linnér, Richard; Gonzalez, Juan Ramon; Muntané, Gerard; Morcillo Suárez, Carlos, 1969-; Navarro i Cuartiellas, Arcadi, 1969-; Beauchamp, Jonathan P. (Nature Research, 2019)
    Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky ...
  • Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
    Paternoster, Lavinia; Gonzalez, Juan Ramon; Bustamante Pineda, Mariona; Tejedor, Elisabeth; Sunyer Deu, Jordi; Weidinger, Stephan (Nature Research, 2015)
    Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, ...
  • Software Application Profile: exposomeShiny-a toolbox for exposome data analysis
    Escriba-Montagut, Xavier; Basagaña Flores, Xavier; Vrijheid, Martine; Gonzalez, Juan Ramon (Oxford University Press, 2022)
    Motivation: Studying the role of the exposome in human health and its impact on different omic layers requires advanced statistical methods. Many of these methods are implemented in different R and Bioconductor packages, ...
  • The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
    Carreras-Gallo, Natàlia; Cáceres, Alejandro; Balagué-Dobón, Laura; Ruiz-Arenas, Carlos; Casas Sanahuja, Maribel; Maitre, Léa; Nieuwenhuijsen, Mark J.; Stratakis, Nikos; Urquiza, José M.; Bustamante Pineda, Mariona; Vrijheid, Martine; Pérez Jurado, Luis Alberto; Gonzalez, Juan Ramon (Nature Research, 2022)
    Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three ...
  • Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
    Castro Giner, Francesc; Künzli, Nino; Jacquemin Leonard, Bénédicte; Forsberg, Bertil; Cid Ibeas, Rafael de; Sunyer Deu, Jordi; Jarvis, Deborah; Briggs, David; Vienneau, Danielle; Norbäck, Dan; Gonzalez, Juan Ramon; Guerra, Stefano; Janson, Christer; Antó i Boqué, Josep Maria; Wjst, Matthias; Heinrich, Joachim; Estivill, Xavier, 1955-; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2009)
    BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association ...
  • Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children
    Casas Sanahuja, Maribel; Basagaña Flores, Xavier; Manzano Salgado, Cyntia Beatriz, 1987-; De Bont, Jeroen, 1989-; Donaire González, David; Gonzalez, Juan Ramon; Gracia Lavedan, Esther; Pañella, Pau; Robinson, Oliver; Urquiza, José M.; Vrijheid, Martine (Elsevier, 2018)
    Background: Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions. Objectives: We evaluated the variability ...