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Browsing by Author "González Ruiz, Juan Ramón"
Now showing items 1-20 of 38
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Hernandez-Ferrer, Carles, 1987-; Quintela Garcia, Ines; Danielski, Katharina; Carracedo, Ángel; Pérez Jurado, Luis Alberto; González Ruiz, Juan Ramón (BioMed Central , 2015)Background:The well-known Genome-Wide Association Studies (GWAS) had led to many scientific discoveriesusing SNP data. Even so, they were not able to explain the full heritability of complex diseases. Now, other ...
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Mercader Bigas, Josep Maria; Ribasés, Marta; Gratacós Mayora, Mònica; González Ruiz, Juan Ramón; Bayés, Mònica; Cid Ibeas, Rafael de; Badía, Anna; Fernández Aranda, Fernando; Estivill, Xavier, 1955- (John Wiley & Sons, 2007)Murine models and association studies in eating disorder (ED) patients have shown a role for the brain-derived neurotrophic factor (BDNF) in eating behavior. Some studies have shown association of BDNF -270C/T single-nucleotide ...
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Vilor Tejedor, Natàlia, 1988- (Universitat Pompeu Fabra, 2018-03-16)Imaging Genetics (IG) aims to test how genetic information influences brain structure and function, cognitive processes and complex neurodevelopmental domains, combining magnetic resonance imaging-based brain features and ...
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Cáceres, Alejandro; Esko, Tõnu; Pappa, Irene; Gutiérrez Arumi, Armand, 1980-; Lopez-Espinosa, Maria-José; Llop, Sabrina; Bustamante Pineda, Mariona; Tiemeier, Henning; Metspalu, Andres; Joshi, Peter K.; Wilsonx, James F.; Reina-Castillón, Judith; Shin, Jean; Pausova, Zdenka; Paus, Tomáš; Sunyer Deu, Jordi; Pérez Jurado, Luis Alberto; González Ruiz, Juan Ramón (Public Library of Science (PLoS) , 2016)The chromosome bands 15q24.1-15q24.3 contain a complex region with numerous segmental duplications that predispose to regional microduplications and microdeletions, both of which have been linked to intellectual disability, ...
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Stratakis, Nikos; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Fossati, Serena; González Ruiz, Juan Ramón; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (JAMA Network, 2020)IMPORTANCE: The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. OBJECTIVE: To assess the associations of fish intake and mercury ...
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Mercader Bigas, Josep Maria; Saus Martínez, Ester; Agüera, Zaida; Bayés, Mònica; Boni, Claudette; Carreras, Anna; Cellini, Elena; Cid Ibeas, Rafael de; Dierssen, Mara; Escaramís, Geòrgia; Fernández Aranda, Fernando; Forcano, Laura; Gallego, Xavier; González Ruiz, Juan Ramón; Gorwood, Philip; Hebebrand, Johannes; Hinney, Anke; Nacmias, Benedetta; Puig, Anna; Ribasés, Marta; Ricca, Valdo; Romo, Lucía; Sorbi, Sandro; Versini, Audrey; Gratacós Mayora, Mònica; Estivill, Xavier, 1955- (Oxford University Press, 2008)Eating disorders (EDs) are complex psychiatric diseases that include anorexia nervosa and bulimia nervosa, and have higher than 50% heritability. Previous studies have found association of BDNF and NTRK2 to ED, while animal ...
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Hernandez-Ferrer, Carles, 1987- (Universitat Pompeu Fabra, 2017-11-14)Las enfermedades complejas se encuentran entre las más comunes y son causadas por una combinación de factores genéticos y ambientales (contaminación ambiental, estilo de vida, etc). Entre las enfermedades complejas que se ...
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Mercader Bigas, Josep Maria; Fernández Aranda, Fernando; Gratacós Mayora, Mònica; Ribasés, Marta; Badía, Anna; Villarejo, Cynthia; Solano, Raquel; González Ruiz, Juan Ramón; Vallejo, Julio; Estivill, Xavier, 1955- (Karger (S. Karger AG), 2007)Background: Evidence of a role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of eating disorders (ED) has been provided by association studies and by murine models. BDNF plasma levels have been found ...
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Rubio Martínez, Mercedes, 1980-; Bustamante Pineda, Mariona; Hernandez-Ferrer, Carles, 1987-; Fernández-Orth, Dietmar; Pantano Rubiño, Lorena, 1982-; Sarria-Trujillo, Yaris; Piqué-Borras, Maria; Vellve del Amo, Kilian; Agramunt, Silvia; Carreras Collado, Ramón; Estivill, Xavier, 1955-; González Ruiz, Juan Ramón; Mayor, Alfredo (Public Library of Science (PLoS), 2018)Circulating small RNAs, including miRNAs but also isomiRs and other RNA species, have the potential to be used as non-invasive biomarkers for communicable and non-communicable diseases. This study aims to characterize and ...
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Aguilar, Daniel; Pinart, Mariona; Benet, Marta; García Aymerich, Judith; González Ruiz, Juan Ramón; Guerra, Stefano; Kogevinas, Manolis; Sunyer Deu, Jordi; Valverde, Sergi; Oliva Miguel, Baldomero; Antó i Boqué, Josep Maria (Public Library of Science (PLoS), 2017)Background: The mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic ...
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López Sánchez, Marcos, 1986- (Universitat Pompeu Fabra, 2018-02-05)Neurodevelopmental disorders are a group of conditions with impairments of the personal, social, academic or occupational behaviour. Autism spectrum disorder is a neurodevelopmental disorder with a high genetic component ...
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Hernandez-Ferrer, Carles, 1987-; González Ruiz, Juan Ramón (Oxford University Press, 2018)SUMMARY: Biomedical studies currently include a large volume of genomic and environmental factors for studying the etiology of human diseases. R/Bioconductor projects provide several tools for performing enrichment analysis ...
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Montaner Domènech, Anna, 1988- (2019-11-11)discovery of cell-free DNA (cfDNA) in blood and the advent of massive parallel sequencing technologies has revolutionized the prenatal screening field by providing a better risk assessment of fetal chromosomal alterations ...
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Salas, Lucas A.; Bustamante Pineda, Mariona; González Ruiz, Juan Ramón; Gracia Lavedan, Esther; Moreno, Víctor; Kogevinas, Manolis; Villanueva Belmonte, Cristina (Taylor & Francis, 2015)Trihalomethanes (THM) are undesired disinfection byproducts (DBPs) formed during water treatment. Mice exposed to DBPs showed global DNA hypomethylation and c-myc and c-jun gene-specific hypomethylation, while evidence of ...
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van Dongen, Jenny; Alemany, Silvia; González Ruiz, Juan Ramón; Sunyer Deu, Jordi; Vrijheid, Martine; Boomsma, Dorret I. (Nature Research, 2021)DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of ...
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Vilor Tejedor, Natàlia, 1988-; González Ruiz, Juan Ramón; Calle, M. Luz (Institute of Electrical and Electronics Engineers (IEEE), 2016)The goal of Genome-wide Association Studies (GWAS) is the identification of genetic variants, usually Single Nucleotide Polymorphisms (SNPs), that are associated with disease risk. However, SNPs detected so far with GWAS ...
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González Ruiz, Juan Ramón; Rodríguez Santiago, Benjamín; Cáceres, Alejandro; Pique Regi, Roger; Rothman, Nathaniel; Chanock, Stephen J.; Armengol i Dulcet, Lluís; Pérez Jurado, Luis Alberto (BioMed Central, 2011)Background: Mosaicism for copy number and copy neutral chromosomal rearrangements has been recently identified as a relatively common source of genetic variation in the normal population. However its prevalence is poorly ...
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Cáceres, Alejandro; González Ruiz, Juan Ramón (Elsevier, 2020)The levels of tau phosphorylation differ between sexes in Alzheimer's disease (AD). Transcriptome-wide associations of sex by disease interaction could indicate whether specific genes underlie sex differences in tau ...
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Esnaola, Mikel; Puig, Pedro; González, David; Castelo Valdueza, Robert; González Ruiz, Juan Ramón (BioMed Central, 2013)Background: High-throughput RNA sequencing (RNA-seq) offers unprecedented power to capture the real dynamics of gene expression. Experimental designs with extensive biological replication present a unique opportunity to ...
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Cáceres, Alejandro; González Ruiz, Juan Ramón (Oxford University Press, 2015)Inversion polymorphisms have important phenotypic and evolutionary consequences in humans. Two different methodologies have been used to infer inversions from SNP dense data, enabling the use of large cohorts for their ...
Now showing items 1-20 of 38
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